Cytokines and intestinal epithelial permeability: A systematic review

Meyer, Frédéric; Wendling, Daniel; Demougeot, Céline; Prati, Clément; Verhoeven, Frank

doi:10.1016/j.autrev.2023.103331

Cited by 20 publications

(12 citation statements)

References 167 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…10 The increased expression of the anti-inflammatory factor IL-10 in the ageing colon provided evidence for the anti-inflammatory effects of NMN; IL-10 has been reported to have a role in the reduction of intestinal permeability. 28 Beneficial microorganisms like Akkermansia muciniphila 29 and Bifidobacterium pseudolongum 30 have been shown to promote an increase in mucus thickness and improve host tight junctions, reducing permeability. Intestinal permeability increases during ageing, 31 and NMN could reverse this process.…”

Section: Discussionmentioning

confidence: 99%

β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice

Gu,

Gao,

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice

Gu,

Gao,

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…20 Thus, increased intestinal permeability, which is one of the major characteristic features in IBD patients, can be directly influenced by cytokines, such as TNF and IL-1β. 21 (MLCs), which are key regulators of intestinal permeation, thereby rearrangements of the actin cytoskeleton and TJ structure. 22 Additionally, it has been reported that patients with IBD have an upregulated MLC kinase (MLCK) level in intestinal tissue, and the association between elevated expression level of MLCK and severity of intestinal inflammation has been reported.…”

Section: Introductionmentioning

confidence: 99%

“…It acts as a gate or barrier for paracellular permeation of various ions and macromolecules . Thus, increased intestinal permeability, which is one of the major characteristic features in IBD patients, can be directly influenced by cytokines, such as TNF and IL-1β . These cytokines can induce the activation of myosin light chains (MLCs), which are key regulators of intestinal permeation, thereby rearrangements of the actin cytoskeleton and TJ structure .…”

Section: Introductionmentioning

confidence: 99%

Geraniin Alleviates Inflammation in Caco-2 Cells and Dextran Sulfate Sodium-Induced Colitis Mice by Targeting IL-1β

Lee,

Jeong,

Park

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

IL-1β is an important cytokine implicated in the progression of inflammatory bowel disease (IBD) and intestinal barrier dysfunction. The polyphenolic compound, geraniin, possesses bioactive properties, such as antitumor, antioxidant, antiinflammatory, antihypertensive, and antiviral activities; however, its IL-1β-targeted anticolitis activity remains unclear. Here, we evaluated the inhibitory effect of geraniin in IL-1β-stimulated Caco-2 cells and a dextran sulfate sodium (DSS)-induced colitis mouse model. Geraniin blocked the interaction between IL-1β and IL-1R by directly binding to IL-1β and inhibited the IL-1β activity. It suppressed IL-1β-induced intestinal tight junction damage in human Caco-2 cells by inhibiting IL-1β-mediated MAPK, NF-kB, and MLC activation. Moreover, geraniin administration effectively reduced colitis symptoms and attenuated intestinal barrier injury in mice by suppressing elevated intestinal permeability and restoring tight junction protein expression through the inhibition of MAPK, NF-kB, and MLC activation. Thus, geraniin exhibits anti-IL-1β activity and anticolitis effect by hindering the IL-1β and IL-1R interaction and may be a promising therapeutic anti-IL-1β agent for IBD treatment.

show abstract

“…This in vitro model has been validated by the OECD and other organizations to replace animal tests in the safety categorization of certain materials. − The intestinal mucosa composed of the organized intestinal epithelium is one of the most expanded cellular monolayers of the human body. Throughout the physiological conditions, it represents a protective physical barrier; preventing the passage of adverse luminal antigens, pathogens, or toxins in the general circulation and simultaneously ensures absorption of physiological nutrients and solutes . EpiIntestinal is an in vitro reconstructed model of the human small intestine epithelium.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and Bioimmunological Activity of Poly(2-Isopropenyl-2-oxazoline) Conjugates with Ibuprofen Using 3D Reconstructed Tissue Models

Kroneková,

Majerčíková,

Paulovičová

et al. 2024

Biomacromolecules

View full text Add to dashboard Cite

Poly(2-isopropenyl-2-oxazoline) (PIPOx) represents a universal polymer platform with pendant 2-oxazoline groups, allowing the preparation of biomaterials for various biomedical applications. However, there is a lack of information on PIPOx concerning the effect of molar mass (M n ) on cytotoxicity and bioimmunological properties. Here, aqueous copper(0)mediated reversible-deactivation radical polymerization (Cu 0 -RDPR) was used for the preparation of PIPOx with defined M n and low dispersity. PIPOx of different M n are used for the synthesis of conjugates with ibuprofen (5 mol %), the nonsteroidal antiinflammatory drug. The release of ibuprofen at 37 °C and different pH values is monitored using high-performance liquid chromatography, where the rate of drug release increases with increasing pH and lower M n . In vitro cytotoxicity and bioimmunological properties of PIPOx and drug conjugates are studied using 3D reconstructed tissue models of the human epidermis and intestinal epithelium. We demonstrate low cytotoxicity of PIPOx and conjugates with different M n values on both 3D tissue models.

show abstract

Cytokines and intestinal epithelial permeability: A systematic review

Cited by 20 publications

References 167 publications

β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice

β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice

Geraniin Alleviates Inflammation in Caco-2 Cells and Dextran Sulfate Sodium-Induced Colitis Mice by Targeting IL-1β

Cytotoxicity and Bioimmunological Activity of Poly(2-Isopropenyl-2-oxazoline) Conjugates with Ibuprofen Using 3D Reconstructed Tissue Models

Contact Info

Product

Resources

About