Cytokines and anticytokines in psoriasis

Pietrzak, Aldona; Zalewska, Anna; Chodorowska, Grażyna; Krasowska, Dorota; Michalak-Stoma, Anna; Nockowski, Piotr; Osemlak, Paweł; Paszkowski, Tomasz; Roliński, Jacek

doi:10.1016/j.cca.2008.04.005

Cited by 141 publications

(173 citation statements)

References 172 publications

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“…TNF-alpha is one of the major cytokines in the pathogenesis of psoriasis. Elevated levels of this cytokine have been reported in many studies in patients with active psoriasis [112,139]. A positive correlation between serum levels of TNF-alpha and PASI has been noted [112].…”

Section: Tumor Necrosis Factor-alpha (Tnf-alpha)mentioning

confidence: 96%

“…It is worth noting that NHEKs expressed much higher amounts of IL-6 after stimulation by IL-17F than by IL-17A or TNF-alpha. The authors suggest that IL-17F may be a crucial cytokine that induces IL-6 expression in NHEKs [112]. IL-6 acts as a chemotactic factor for T cells, thus it stimulates the migration of T cells into the epidermis.…”

Section: Interleukin-6 (Il-6)mentioning

confidence: 99%

“…IL-6 acts as a chemotactic factor for T cells, thus it stimulates the migration of T cells into the epidermis. IL-6 influences the growth and differentiation of dermal and epidermal cells [112] and is also involved in hematopoiesis [112].…”

Section: Interleukin-6 (Il-6)mentioning

confidence: 99%

“…It also induces antibacterial features of neutrophils. Apart from that, IL-8 induces angiogenesis and influences other cells, which take part in inflammatory response including: T lymphocytes, natural killer cells (NK) and basophils, and it is also chemotactic towards keratinocytes [112,120,121].…”

Section: Interleukin-8 (Il-8)mentioning

confidence: 99%

“…TNF-alpha influences the proliferation, activation or differentiation of many cells [131]. TNF-alpha also increases the synthesis of some proinflammatory cytokines, growth factors and adhesive molecules [112]. Several studies have shown that TNF-alpha may impair insulin signaling in many cells such as liver, adipose tissue or skeletal muscles [132][133][134].…”

Section: Tumor Necrosis Factor-alpha (Tnf-alpha)mentioning

confidence: 99%

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Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

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Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.

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Section: Tumor Necrosis Factor-alpha (Tnf-alpha)mentioning

confidence: 96%

Section: Interleukin-6 (Il-6)mentioning

confidence: 99%

Section: Interleukin-6 (Il-6)mentioning

confidence: 99%

Section: Interleukin-8 (Il-8)mentioning

confidence: 99%

Section: Tumor Necrosis Factor-alpha (Tnf-alpha)mentioning

confidence: 99%

See 3 more Smart Citations

Biochemical markers of psoriasis as a metabolic disease

Gerkowicz

Pietrzak

Szepietowski

et al. 2012

Folia Histochem Cytobiol.

Self Cite

View full text Add to dashboard Cite

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Advances in Lipid‐Based Codelivery Systems for Cancer and Inflammatory Diseases

Jogdeo

Panja

Kanvinde

et al. 2022

Adv Healthcare Materials

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Combination therapy targeting multiple therapeutic targets is a favorable strategy to achieve better therapeutic outcomes in cancer and inflammatory diseases. Codelivery is a subfield of drug delivery that aims to achieve combined delivery of diverse therapeutic cargoes within the same delivery system, thereby ensuring delivery to the same site and providing an opportunity to tailor the release kinetics as desired. Among the wide range of materials being investigated in the design of codelivery systems, lipids have stood out on account of their low toxicity, biocompatibility, and ease of formulation scale-up. This review highlights the advances of the last decade in lipid-based codelivery systems focusing on the codelivery of drug-drug, drug-nucleic acid, nucleic acid-nucleic acid, and protein therapeutic-based combinations for targeted therapy in cancer and inflammatory diseases.

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Semiquinone glucoside derivative provides protection against γ-radiation by modulation of immune response in murine model

et al. 2014

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Present study was undertaken to evaluate radioprotective and immunomodulatory activities of a novel semiquinone glucoside derivative (SQGD) isolated from Bacillus sp. INM-1 in C57 BL/6 mice. Whole body survival study was performed to evaluate in vivo radioprotective efficacy of SQGD. To observe effect of SQGD on immunostimulation, Circulatory cytokine (i.e., interleukin-2 (IL-2), IFN-γ, IL-10, granulocyte colony stimulating factor (G-CSF), granulocyte macrophage colony stimulating factor (GM-CSF), and macrophage colony stimulating factor (M-CSF) expression was analyzed in serum of irradiated and SQGD treated mice at different time intervals using ELISA assay. Results of the present investigation indicated that SQGD pre-treatment (-2 h) to lethally irradiated mice provide ∼ 83% whole body survival compared with irradiated mice where no survival was observed at 30(th) post irradiation day. Significant (p < 0.05) induction in IL-2 and IFN-γ expression was observed at all tested time intervals with SQGD pre-treated irradiated mice as compared with irradiated mice alone. However, sharp increase in IL-10 expression was observed in irradiated mice which were found to be subsidized in irradiated mice pre-treated with SQGD. Similarly, significant (p < 0.05%) induction in G-CSF, M-CSF and GM-CSF expression was observed in irradiated mice treated with SQGD as compared with irradiated control mice at tested time intervals. In conclusion, SQGD pre-treatment to irradiated mice enhanced expression of IL-12 and IFN-γ while down-regulated IL-10 expression and thus modulates cytoprotective pro-inflammatory TH1 type immune response in irradiated mice. Further, SQGD pre-treatment to irradiated mice accelerate G-CSF, GM-CSF and M-CSF expression suggesting improved haematopoiesis and enhanced cellular immune response in immuno-compromised irradiated mice that may contribute to in vivo radiation protection.

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Cytokines and anticytokines in psoriasis

Cited by 141 publications

References 172 publications

Biochemical markers of psoriasis as a metabolic disease

Biochemical markers of psoriasis as a metabolic disease

Advances in Lipid‐Based Codelivery Systems for Cancer and Inflammatory Diseases

Semiquinone glucoside derivative provides protection against γ-radiation by modulation of immune response in murine model

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