Cytokine Profiles in Peripheral Blood and Whole Blood Cell Cultures Associated With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis

Havemose-Poulsen, Anne; Sørensen, Lars Korsbæk; Stoltze, Kaj; Bendtzen, Klaus; Holmstrup, Palle

doi:10.1902/jop.2005.76.12.2276

Cited by 88 publications

(98 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…c) Rheumatoid arthritis (RA): Recent studies seem to assert the existence of a relationship between periodontal disease and RA (19)(20)(21)(22)(23)(24)(25)(26)(27). Some authors even affirm that the two diseases have so much in common that they represent the same disease (28).…”

Section: Oral Capillaroscopy and Autoimmune Pathologiesmentioning

confidence: 99%

Oral microcirculation observed in vivo by videocapillaroscopy: a review

2009

View full text Add to dashboard Cite

Capillaroscopy is a non-invasive diagnostictechnique that is fundamental in viewing peripheral circulation and in studying microangiopathies. The morphological study of microcirculation is of fundamental importance, mainly because the microvascular bed is directly involved in the etiopathogenesis of autoimmune disorders and acute and chronic inflammatory pathological conditions. The value of capillaroscopic investigation as a diagnostic means in cases of peripheral microcirculation disorders has been confirmed by numerous studies. Other studies used capillaroscopic investigations to evaluate microcirculation damage not as a complication of disease (diabetes), but as its initial stage, and therefore to make a diagnosis. Capillaroscopy is an interesting method of studying microcirculation, because of the possibility of studying small vessels in vivo by means of a microscope. Today, it has become more reliable, thanks to the development of observation tools (photography, videomicroscopy). This review describes in detail various aspects of the microcirculation of the oral mucosa. (J Oral Sci 51, 1-10, 2009)

show abstract

Section: Oral Capillaroscopy and Autoimmune Pathologiesmentioning

confidence: 99%

Oral microcirculation observed in vivo by videocapillaroscopy: a review

2009

View full text Add to dashboard Cite

show abstract

“…This increase in pro-inflammatory TNF-α during periodontitis has been well documented [35], and it is known to play a substantial role in periodontitis mediated bone loss [36]. The concomitant increase in anti-inflammatory IL-10 in the periodontitis group is however more surprising, although it has been previously observed [37][38][39]. One hypothesis explaining the observed concomitant pro-and anti-inflammatory response is that aggressive periodontitis would stimulate a strong increase in TNF-α, which in turn could activate a counteracting anti-inflammatory IL-10 response to avoid overactivation of inflammation.…”

mentioning

confidence: 84%

Section: Page 6 Ofmentioning

confidence: 99%

“…Another hypothesis would be that during chronic generalised periodontitis, IL-10 would increase resulting in an "anti-inflammatory" state in the mouth, facilitating the dissemination of dental bacteria to extra-oral sites, which then would activate a proinflammatory response in the foetal-placental unit and therefore trigger PTB. For example, Havemose et al showed a concomitant increase in TNF-α and IL-10 in patients with generalised aggressive periodontitis, but IL-10 alone was not increased in patients with localised aggressive periodontitis [38].High concentrations of MCP-1 (≥ 350 pg/ml) in umbilical cord blood significantly increased the likelihood of PTB. This finding was also described by Matoba et al who quantified twenty-seven types of cytokines in cord blood at different gestational ages and found that MCP-1 was the one that was most strongly associated with PTB [40].…”

mentioning

confidence: 99%

See 1 more Smart Citation

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

M¹,

Gayet-Ageron²,

Roux‐Lombard³

et al. 2017

Gynecol Obstet

View full text Add to dashboard Cite

Citation: Lumbreras Areta M, Gayet-Ageron A, Roux-Lombard P, Schrenzel J, AbstractBackground: Comparing microbiologic and inflammatory markers of periodontitis with those of preterm birth (PTB).Methods: Secondary analysis of a prior prospective case-control study done at the Geneva University Hospitals. Cases were women delivering at 22-34 6/7 weeks (early PTB, n=30) and controls were women delivering at ≥ 37 weeks (term delivery, n=87). We collected dental plaque during labour to quantify RNA levels from Aggregatibacter actinomycetemcomitans (Aa), Tannerella forsythia (Tf), Porphyromonas gingivalis (Pg) and Treponema denticola (Td). We also collected cord blood for cultures and cytokine quantification (IL-1Ra, IL-6, IL-8, IL-10, IL-17, TNF-α, MCP-1 and RANTES). Periodontal status was evaluated at the immediate postpartum using the American Consensus definition. Data was analysed by univariate and multivariate logistic regression.Results: Levels of Pg and Td were significantly higher in dental plaque of women with severe and moderate periodontitis. Microbiologic composition of dental plaque was not different between preterm and term delivery groups. There were no differences in cord blood cultures between groups. Cord TNF-α ≥ 8 pg/ml and IL-10 ≥ 1.3 pg/ml were associated with a higher risk of periodontitis (OR 2.78, 95% CI: 1.09-7.13, P=0.033; OR 2.78, 95% CI: 1.09-7.08, P=0.032 respectively), but differences were not significant at multivariate analysis. Cord MCP-1 ≥ 350 pg/ml was associated with a higher risk of PTB at both univariate (OR 40.25, P<0.001) and multivariate analysis (OR 53.71, P<0.001). Conclusion:In labour, microbiologic markers and inflammatory responses associated with periodontitis and PTB are different. The mechanisms linking periodontitis and PTB therefore still need to be elucidated. Page 2 of 9Citation: Lumbreras Areta M, Gayet-Ageron A, Roux-Lombard P, Schrenzel J, 2.38, 95% CI: 1.36-4.14, P=0.002) [20]. In this secondary analysis, we aim to compare the type of bacteria (in dental plaque and cord blood) and cytokines/chemokines (in cord blood) in women with severe periodontitis with those in women with early PTB. The objective is to determine if the microbiological and/or inflammatory pathways in periodontitis are the same as those involved in early PTB. A shared molecular pathway would explain the aetiology of the association between periodontitis and increased risk of PTB that was observed in our previous study. Methods Study designThis is a planned secondary analysis of women included in a prior prospective case-control (1:4) study performed between 09 November, 2007 and 18 March, 2010 at the maternity unit of the Geneva University Hospitals, Switzerland [20]. Briefly, the study evaluated the association of periodontitis in cases (women delivering spontaneously between 22 and 34, 6/7 weeks of gestation) compared to controls (women delivering as term [≥ 37 weeks]). The study was approved by the Ethics Committee of Geneva (study number 07-008, approved 28 March 2007). All partic...

show abstract

“…IL-6 is a multifunction cytokine that has a wide range of biological activities and shows markedly elevated levels in oJIA patients [20].…”

Section: Introductionmentioning

confidence: 99%

Distinct Cytokine Profiles in Patients with Oligoarticular Juvenile Idiopathic Arthritis after <i>in</i> <i>Vitro</i> Blockade of Interleukin (IL)-1 and Tumor Necrosis Factor (TNF)-α

Kirchner¹,

Strothmann²,

Sonnenschein³

et al. 2014

WJV

View full text Add to dashboard Cite

Oligoarticular juvenile idiopathic arthritis (oJIA) is an antigen-driven and lymphocyte-mediated autoimmune disorder with irregularity in the adaptive immune system. Auto reactive T cells, activated by cartilage-derived auto antigens, produce pro-inflammatory cytokines as IFN-γ and IL-17. Failure of regulatory T cells leads to decreased anti-inflammatory cytokine IL-10 production and results in the loss of immune tolerance. This activation of innate and adaptive immunity stimulates the release of pro-inflammatory cytokines IL-1, IL-6 and TNF-α. Thus, inhibition of these cytokines is considered as an appropriate therapeutic strategy for oJIA. The aim of this study was to investigate whether the blockade of a single cytokine pathway in the present cytokine setting causes an unfavourable imbalance in the cytokine system or whether the blockade is sufficient to suppress the inflammatory condition. We examined the cytokine secretion after in vitro inhibition of IL-1 and TNF-α of patients with oJIA and healthy subjects. This single center cohort study consisted of oJIA affected children and control subjects. Cytokine profiles from cell culture supernatants were examined with multiplex fluorescent bead immunoassay by flow cytometry. Adalimumab prevents highly effective and very selective effect of the cytokine TNF-α. Due to its structure, the mode of action of etanercept is difficult to display. In addition, adalimumab and etanercept appear in vitro suppressive to IFN-γ. The efficiency of both substances is particularly supported by the increased secretion of anti-inflammatory cytokine IL-4. In contrast, anakinra unselectively inhibits the pro-inflammatory macrophage cytokines. To conclude, our observations suggest that inhibition of IL-1 or TNF-α may contribute to the unselective decline of other pro-inflammatory cytokines in oJIA patients. The selective anti-inflammatory effect of cytokine inhibitors is most * Corresponding author. M. Kirchner et al. 111likely supported by an increase of IL-4 or IL-10. It still remains to be elucidated whether the reduced IFN-γ secretion is maybe causative for the increased susceptibility to infections with opportunistic pathogens.

show abstract

Cytokine Profiles in Peripheral Blood and Whole Blood Cell Cultures Associated With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis

Abstract: Patients with aggressive periodontitis and types of arthritis presented with similar components of blood cytokine profiles distinguishing them from individuals free of disease.

Cited by 88 publications

References 67 publications

Oral microcirculation observed in vivo by videocapillaroscopy: a review

Oral microcirculation observed in vivo by videocapillaroscopy: a review

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

Distinct Cytokine Profiles in Patients with Oligoarticular Juvenile Idiopathic Arthritis after <i>in</i> <i>Vitro</i> Blockade of Interleukin (IL)-1 and Tumor Necrosis Factor (TNF)-α

Contact Info

Product

Resources

About

Cytokine Profiles in Peripheral Blood and Whole Blood Cell Cultures Associated With Aggressive Periodontitis, Juvenile Idiopathic Arthritis, and Rheumatoid Arthritis

Abstract: Patients with aggressive periodontitis and types of arthritis presented with similar components of blood cytokine profiles distinguishing them from individuals free of disease.

Cited by 88 publications

References 67 publications

Oral microcirculation observed in vivo by videocapillaroscopy: a review

Oral microcirculation observed in vivo by videocapillaroscopy: a review

Microbiologic and Inflammatory Markers of Periodontitis are Different to those of Preterm Birth

Distinct Cytokine Profiles in Patients with Oligoarticular Juvenile Idiopathic Arthritis after &lt;i&gt;in&lt;/i&gt; &lt;i&gt;Vitro&lt;/i&gt; Blockade of Interleukin (IL)-1 and Tumor Necrosis Factor (TNF)-α

Contact Info

Product

Resources

About

Distinct Cytokine Profiles in Patients with Oligoarticular Juvenile Idiopathic Arthritis after <i>in</i> <i>Vitro</i> Blockade of Interleukin (IL)-1 and Tumor Necrosis Factor (TNF)-α