Cytokine production by peripheral blood mononuclear cells of women with a history of preterm birth

Evaluation of Serum High-Sensitivity C-Reactive Protein Levels During Various Periods of Pregnancy in Woman, Infected With Parvovirus - B19 Infection

“…Hs-CRP is one of the early components, which can protect from infection [12,13]. Just 2-4 hours after invasion, the level of hs-CRP increases, that lead to stimulation ofimmune reactions, such as phagocytosis, induction of pro-inflammatory cytokines(IL-1, IL-6, TNF-a) [14], monocyte tissue factor and activation of classicalcomplement pathway. Therefore, hs-CRP is considered as the most sensitive andrapid indicator of tissue damage during inflammatory process and it helps to detecteven minimal inflammation, and make faster diagnostic process for using the optimal treatment strategy [15,16].…”

Whole blood flow cytometric analysis of Ureaplasma-stimulated monocytes from pregnant women

“…10 6 CCU/mL heat-killed UpSV3 (Triantafilou et al, 2013;Manimtim et al, 2001) has previously been shown to elicit robust responses in PBMCs from non-pregnant women and choriodecidual explants (Peltier et al, 2010;Aaltonen et al, 2007) with stimulation occurring via synergistic activation of multiple TLRs (1, 2, 6 and 9) (Triantafilou et al, 2013;Shimizu et al, 2008). Moreover, we have highlighted the stimulatory capacity of the 10B growth medium, demonstrating the importance of including this often omitted control in future stimulation assays, particularly when examining cells prone to non-specific activation such as monocytes.…”

“…Primary exposure to microbial ligands, for example, can induce immune cell reprogramming towards priming for an enhanced response upon restimulation or tolerance, resulting in decreased responsiveness. Peltier et al (2010) hypothesised that peripheral blood mononuclear cells (PBMCs) isolated from non-pregnant women with a history of PTB would produce greater amounts of TNF-␣, http://dx.doi.org/10.1016/j.jri.2014.12.008 0165-0378/© 2015 Elsevier Ireland Ltd. All rights reserved. suggestive of a primed response when restimulated with bacteria associated with PTB (including Ureaplasma spp.).…”

Immunological features of parvovirus infection in different pregnancy periods.

“…При вторгненні в організм матері інфекційних агентів у великій кількості мобілі-зуються всі ресурси і запускається механізм пов-ноцінної активації T-лімфоцитів і неспецифіч-ного (вродженого) імунітету [4]. Тому імунна система матері знаходиться в стані постійної готовності включення Th1-шляху у відповідь на інфекційну дію [9,14]. Питання про характер по-рушень імунного статусу при парвовірусній ін-фекції потребують детального вивчення.…”