2007
DOI: 10.1016/j.jaci.2007.04.031
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Background-Atopic dermatitis (AD) is a chronic inflammatory skin disease that is characterized by a defective skin barrier function. Recent studies have reported mutations of the skin barrier gene encoding filaggrin in a subset of patients with AD.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

30
535
4
16

Year Published

2009
2009
2016
2016

Publication Types

Select...
4
4

Relationship

0
8

Authors

Journals

citations
Cited by 830 publications
(585 citation statements)
references
References 25 publications
30
535
4
16
Order By: Relevance
“…As another component of Gram-negative bacteria, LPS, is present in house dust [26], flagellin also might be present in house dust. Barrier dysfunction in the skin occurs in infancy at high frequency, is genetically determined or is induced by endogenous or environmental factors [27,28,29,30,31,32,33]. Exposure of barrier-defected skin to Gram-negative bacteria or environmental flagellin might contribute to the initiation and/or amplification of Th2 inflammation via the induction of TSLP expression in keratinocytes.…”
Section: Discussionmentioning
confidence: 99%
“…As another component of Gram-negative bacteria, LPS, is present in house dust [26], flagellin also might be present in house dust. Barrier dysfunction in the skin occurs in infancy at high frequency, is genetically determined or is induced by endogenous or environmental factors [27,28,29,30,31,32,33]. Exposure of barrier-defected skin to Gram-negative bacteria or environmental flagellin might contribute to the initiation and/or amplification of Th2 inflammation via the induction of TSLP expression in keratinocytes.…”
Section: Discussionmentioning
confidence: 99%
“…25 Recent studies suggest that the filaggrin gene (heritable epithelial barrier) defect is associated with atopic dermatitis and potentially accounts for diminished epidermal defence mechanisms against microbial organisms and allergens. 26 The association between filaggrin gene mutation and the increased risk of allergic rhinitis has been also demonstrated. 27 A potential involvement of filaggrin in atopic marching (progression of atopic disease from atopic dermatitis to asthma and/or allergic rhinitis) has been suggested based on the predictive role of filaggrin gene mutation in the development of asthma.…”
Section: Interpretation Of Findings In Relation To Previously Publishmentioning
confidence: 99%
“…27 A potential involvement of filaggrin in atopic marching (progression of atopic disease from atopic dermatitis to asthma and/or allergic rhinitis) has been suggested based on the predictive role of filaggrin gene mutation in the development of asthma. 26 Importantly, Th2 cytokines such as interleukin (IL)-4 and IL-13 significantly downregulate filaggrin gene expression which makes the skin more susceptible to infection and allergic sensitization. 28 Alternatively, Th2 cytokine gene polymorphisms might be associated with humoral immune functions such as pneumococcal antibody responses.…”
Section: Interpretation Of Findings In Relation To Previously Publishmentioning
confidence: 99%
“…At the protein level, FLG expression is very distinctly decreased or even obliterated in FLG mutation carriers [5], while mRNA levels may be less distinctly impaired [6]. Howell et al [7] recently documented a decrease in FLG transcript and protein in acute AD lesions and related it to the influence of IL-4 and IL-13. …”
Section: Introductionmentioning
confidence: 99%
“…While the expression of FLG in AD has been studied extensively at both the RNA and protein level [5, 7], data concerning the expression of other CE genes are far less consistent [5, 13, 14]. We decided to study RNA expression because it has been proven that EDC genes are regulated mainly at the transcriptional level [15, 16].…”
Section: Introductionmentioning
confidence: 99%