Cytokine levels predict 30-day mortality in octogenarians and nonagenarians with community-acquired pneumonia: a retrospective observational study

Pinargote‐Celorio, Héctor; Miralles, Gemma; Cano, Miguel Ángel; Caparrós, Esther; Portilla, J.; González‐Alcaide, Gregorio; Ramos‐Rincón, José‐Manuel

doi:10.1007/s10096-019-03725-6

Cited by 9 publications

(9 citation statements)

References 34 publications

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“…Pinargote-Celorio et al recently confirmed previous findings suggesting that proinflammatory cytokines (IL-6, IL-8) and anti-inflammatory cytokines (IL-10) could predict one-month mortality for CAP in elderly patients [14,18]. IL-6 is a cytokine of the acute phase and has been mostly described as a risk factor for early mortality [15,44].…”

Section: Discussionmentioning

confidence: 71%

“…Serum amyloid A protein (SAA), neopterin (NP), myeloperoxidase (MPO), anti-apolipoprotein A-1 IgG (anti-apoA-1), and anti-phosphorylcholine IgM (anti-PC IgM) have been recently investigated in the same context and/or in cardiovascular diseases [ 9 , 10 , 11 , 12 , 13 ]. An association between high levels of pro and anti-inflammatory cytokines (especially interleukin (IL)-1, -6, and -11) with short- and long-term mortality of CAP has been described, but information concerning elderly patients is lacking [ 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Role of Clinical Characteristics and Biomarkers at Admission to Predict One-Year Mortality in Elderly Patients with Pneumonia

Malézieux-Picard¹,

Azurmendi

Pagano

et al. 2021

JCM

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Background: A hospitalization for community-acquired pneumonia results in a decrease in long-term survival in elderly patients. We assessed biomarkers at admission to predict one-year mortality in a cohort of elderly patients with pneumonia. Methods: A prospective observational study included patients >65 years hospitalized with pneumonia. Assessment of PSI, CURB-65, and biomarkers (C-reactive protein (CRP), procalcitonin (PCT), NT-pro-B-type natriuretic peptide (NT-proBNP), interleukin (IL)-6 and -8, tumor necrosis factor alpha (TNF-α), serum amyloid A (SAA), neopterin (NP), myeloperoxidase (MPO), anti-apolipoprotein A-1 IgG (anti-apoA-1), and anti-phosphorylcholine IgM (anti-PC IgM)) was used to calculate prognostic values for one-year mortality using ROC curve analyses. Post hoc optimal cutoffs with corresponding sensitivity (SE) and specificity (SP) were determined using the Youden index. Results: A total of 133 patients were included (median age 83 years [IQR: 78–89]). Age, dementia, BMI, NT-proBNP (AUROC 0.65 (95% CI: 0.55–0.77)), and IL-8 (AUROC 0.66 (95% CI: 0.56–0.75)) were significantly associated with mortality, with NT-proBNP (HR 1.01 (95% CI 1.00–1.02) and BMI (HR 0.92 (95% CI 0.85–1.000) being independent of age, gender, comorbidities, and PSI with Cox regression. At the cutoff value of 2200 ng/L, NT-proBNP had 67% sensitivity and 70% specificity. PSI and CURB-65 were not associated with mortality. Conclusions: NT-proBNP levels upon admission and BMI displayed the highest prognostic accuracy for one-year mortality and may help clinicians to identify patients with poor long-term prognosis.

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Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Role of Clinical Characteristics and Biomarkers at Admission to Predict One-Year Mortality in Elderly Patients with Pneumonia

Malézieux-Picard¹,

Azurmendi

Pagano

et al. 2021

JCM

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“…36 Moreover, expression levels of miR-193a-5p were related to the duration of the required hospital stay in our study. Identified molecular targets of miR-193a-5p included IL-10, which is known to correlate with the CURB-65 score and is associated with increased mortality in patients with CAP 37 and mTOR, which has been shown to be down-regulated in sepsis due to CAP. 38 Our group previously showed the positive correlation of cell-free miR-193a-5p expression with disease severity in sepsis patients.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic potential of circulating cell‐free microRNAs for community‐acquired pneumonia and pneumonia‐related sepsis

Hermann

Brandes

Kirchner

et al. 2020

J Cellular Molecular Medi

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“…In recent decades, our knowledge of the biochemical processes underlying critical illness has considerably improved. We realized that cytokines perform important roles in host defense and maintenance of tissue homeostasis; however, abnormal or excessive production of cytokines disrupts these functions, resulting in inflammation and tissue injury [17], and there is strong evidence that cytokines work as important mediators of inflammatory and immunologic diseases and that elevated cytokine levels can contribute to organ dysfunction [18][19][20]. Evidence suggests that cytokines, including IL-8, TNF-a, and IL-10, strongly predict clinical outcome alone or in combination with other variables or widely accepted severity scores [21,22].…”

Section: Discussionmentioning

confidence: 99%

The associations between cytokine levels and clinical outcomes in critically ill patients after surgery: a retrospective cohort study

Yan¹,

Wang²,

Hu³

et al. 2020

Preprint

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Background The associations of serum cytokine levels and critically ill patient outcomes after surgery remain unclear. The use of cytokine markers to predict outcomes in critically ill patients is controversial. Objective To determine the levels of IL-1β, IL-2, IL-6, IL-8, IL-10, TNF-α and procalcitonin in critical surgical ICU (SICU) patients and evaluate their associations with patient outcome and clinical significance. Methods This was a retrospective cohort study of consecutive patients admitted to the SICU in Zhongshan Hospital, Fudan University. The program ran from January 1, 2018, to June 30, 2019. The levels of IL-1β, IL-2, IL-6, IL-8, IL-10, TNF-α and procalcitonin were detected, and their relationship with patient outcomes was investigated. The primary outcome was in-hospital mortality, compared by a multivariable logistic regression analysis among the survivors and nonsurvivors. Results Overall, 5,257 patients were included in this study for their first SICU admission; 5,099 patients survived, 158 patients died, and the mortality rate was 3.0% (158/5,257). Univariate and multivariate analyses showed that nonsurvivors had increased levels of IL-1β (OR = 1.855, P = 0.000) and IL-2 (OR = 1.51, P = 0.000) compared with survivors. In addition, 196 patients (3.7%) were readmitted to the SICU, and data from 187 patients were collected. Of these, 161 patients survived, and 26 patients died; the mortality rate was 13.9% (26/187), which was much higher than that of the first round of patients. The level of IL-2 significantly influenced SICU readmission (OR = 3.921, P = 0.000). For the third round of SICU admission, 10 patients were included, 7 patients survived, and 3 patients died; the mortality rate was 30.0% (3/10). Furthermore, older age, longer time of SICU stay, and higher rate of mechanical ventilation and CRRT were associated with patient death. Conclusions High levels of cytokines may be risk factors for mortality and SICU readmission in critically ill patients who receive surgery. Further work is still needed to determine which unmeasured characteristics and therapies may contribute to the increased risk observed.

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Cytokine levels predict 30-day mortality in octogenarians and nonagenarians with community-acquired pneumonia: a retrospective observational study

Cited by 9 publications

References 34 publications

Role of Clinical Characteristics and Biomarkers at Admission to Predict One-Year Mortality in Elderly Patients with Pneumonia

Role of Clinical Characteristics and Biomarkers at Admission to Predict One-Year Mortality in Elderly Patients with Pneumonia

Diagnostic potential of circulating cell‐free microRNAs for community‐acquired pneumonia and pneumonia‐related sepsis

The associations between cytokine levels and clinical outcomes in critically ill patients after surgery: a retrospective cohort study

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