1998
DOI: 10.1161/01.cir.98.2.149
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Abstract: These findings suggest the possible involvement of cytokines during the remodeling process of the noninfarcted left ventricular myocardium.

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Cited by 394 publications
(299 citation statements)
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“…corresponded to the chronic remodelling phase [30]. We next examined the functional implications of sitagliptin-attenuated resistin secretion, and found that resistin played an important role in sympathetic innervation and arrhythmias through modulation of NGF levels.…”
Section: Figurementioning
confidence: 99%
“…corresponded to the chronic remodelling phase [30]. We next examined the functional implications of sitagliptin-attenuated resistin secretion, and found that resistin played an important role in sympathetic innervation and arrhythmias through modulation of NGF levels.…”
Section: Figurementioning
confidence: 99%
“…The cytokines LIF and IL-6 are also elevated in the heart following myocardial infarction [22][23][24][25][26], and compensatory upregulation of these cytokines might protect heart cells in the absence of CT-1. Similarly, NP/CT-2 might be induced following ischemia along with other embryonic genes.…”
Section: Resultsmentioning
confidence: 99%
“…LIF, IL-6, and IL-6R protein are elevated in cardiac myocytes following myocardial infarction [22][23][24]26]. These cytokines prevent apoptosis and stimulate cardiac hypertrophy in a manner essentially indistinguishable from the actions of CT-1.…”
Section: Discussionmentioning
confidence: 97%
“…38 In a rat model TNF-mRNA was upregulated in both the infarcted and non-infarcted areas in the early stage after MI, but remained upregulated in the non-infarcted area for nearly 28 days. 39 This expression of the TNF-gene in the non-infarcted area suggests that the cytokine may be involved in the signaling process leading to myocardial remodeling. A study by Sun et al demonstrated that LV chamber dilatation and decreased LV developed pressure were less in TNF-KO mice than in WT mice at 28 days after coronary ligation, 18 and in the present study the LVEDd was significantly smaller in the KO mice than in the WT mice at each time point after MI.…”
Section: Tnf-and Myocardial Remodelingmentioning
confidence: 98%