Cytokine Comparisons Between Women With Breast Cancer and Women With a Negative Breast Biopsy

Lyon, Debra E.; McCain, Nancy L.; Walter, Jeanne; Schubert, Christine M.

doi:10.1097/01.nnr.0000280655.58266.6c

Cited by 97 publications

(77 citation statements)

References 26 publications

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“…BORIS may thus act as a positive regulator of hTERT transcription, and interestingly, high levels of BORIS have been detected in blood leukocytes from breast cancer patients compared with controls (27). Another observation is that the levels of a number of potentially telomerase activating cytokines, like interleukin 2 (IL-2), IL-4, IL-6, IL-7, IL-10, and IL13 (28)(29)(30)(31)(32), were found at higher serum levels in breast cancer patients compared with controls (33).…”

Section: Discussionmentioning

confidence: 97%

Breast Cancer Survival Is Associated with Telomere Length in Peripheral Blood Cells

Svenson¹,

Nordfjäll²,

et al. 2008

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Telomeres are essential for maintaining chromosomal stability. Previous studies have indicated that individuals with shorter blood telomeres may be at higher risk of developing various types of cancer, such as in lung, bladder, and kidney. We have analyzed relative telomere length (RTL) of peripheral blood cells in relation to breast cancer incidence and prognosis. The study included 265 newly diagnosed breast cancer patients and 446 female controls. RTL was measured by real-time PCR, and our results show that the patient group displayed significantly longer telomeres compared with controls (P < 0.001). Age-adjusted odds ratios (OR) for breast cancer risk increased with increasing telomere length, with a maximal OR of 5.17 [95% confidence interval (95% CI), 3.09-8.64] for the quartile with the longest telomeres. Furthermore, RTL carried prognostic information for patients with advanced disease. Node positive (N+) patients with short telomeres (Vmedian) showed an increased survival compared with N+ patients with long telomeres (P = 0.001). For patients with ages <50 years with tumors >16 mm (median tumor diameter), short telomeres were associated with a significantly better outcome than longer telomeres (P = 0.006). Cox regression analysis showed that long RTL was a significant independent negative prognostic factor (hazards ratio, 2.92; 95% CI, 1.33-6.39; P = 0.007). Our results indicate that blood RTL may serve as a prognostic indicator in breast cancer patients with advanced disease. [Cancer Res 2008;68(10):3618-23]

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Section: Discussionmentioning

confidence: 97%

Breast Cancer Survival Is Associated with Telomere Length in Peripheral Blood Cells

Svenson¹,

Nordfjäll²,

et al. 2008

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“…The mechanism of IL-8 action in estrogen receptor-negative breast cancer is largely unknown (25). The high level of IL-8 in estrogen receptor (ER) negative breast cancer cell is associated with higher invasion potential of these cells (41,42). Malonia et al reported that breast cancer cells with lacking estrogen receptor generate more interleukin-8 (34).…”

Section: Il-8 and Estrogen Receptorsmentioning

confidence: 99%

The Role of Interleukin-8 and Its Mechanism in Patients with Breast Cancer: Its Relation with Oxidative Stress and Estrogen Receptor

Sheikhpour

2017

Int J Cancer Manag

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Context: Breast cancer is one of the leading causes of death among women all over the world. Prognostic markers can be used for patient survival. Likewise, these biomarkers are able to generate main information related to clinical manner of breast gland tumors. Interleukin-8 (IL-8) is a chemotactic cytokines caused initiation of an inflammatory response. Evidence Acquisition: We performed a computerized search in Medline/PubMed databases with key words: IL-8, breast cancer, and oxidative stress. Results: IL-8 secretion motivates the expression of adhesion molecule, including fibronectin in human inflammatory breast cancer cells. IL-8 activates PI3K/Akt pathway, which in turn activates NF-κB resulted up-regulation of integrin β3 expression and increases the invasion of breast cancer cells. Therefore, it seems that IL-8/PI3K/Akt/NF-κB/integrin β3 axis may be used for therapeutic intervention of breast cancer with metastasis status. NF-κB plays an important role in IL-8 gene transcription via several signals, such as LPS, TNF-alpha, and oxidative stress. Oxidative stress caused angiogenic factor production, such as vascular endothelial growth factor and IL-8 via cancer cells. Moreover, there is inverse relation between ER level and IL-8, but the mechanism of IL-8 action in estrogen receptor-negative breast cancer is largely unknown. Estrogen receptor and growth factor in breast cancer cells is influenced by mitogen activated protein kinase (MAPK) cascade, as a part of IL-8 signaling pathway. Conclusions: According to these studies, interleukin-8 may be as a main biomarker for breast cancer. It seems that signaling pathway of IL-8 may be used for therapeutic intervention of breast cancer. Also oxidative stress and breast cancer cells with lacking estrogen receptor generate more interleukin-8.

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“…A few studies have documented IL10 expression in breast cancer [8][9][10][11]. Serum IL10 concentration is raised in breast cancer patients compared to normal healthy females [12], while other failed to show any association between breast cancer and serum IL10 concentration [13]. IL10 expressing tumours are often ER-ve and associated with apoptotic marker Bax, suggesting a possible aggressive behaviour of IL 10 expressing tumours [9,10].…”

Section: Introductionmentioning

confidence: 99%

Is Interleukin 10 (IL10) Expression in Breast Cancer a Marker of Poor Prognosis?

Bhattacharjee

Bansal

Nepal

et al. 2016

Indian J Surg Oncol

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Interleukin 10 (IL10) is a poor prognostic marker in several cancers. Its role in breast cancer is not well elucidated. The present study is designed to see the expression of IL10 in breast cancer tissue and to evaluate its correlation with the established markers of prognosis. Sixty female patients who underwent surgery for breast cancer were enrolled for the study. Immediately after surgery, 2-5 g of tumour tissue and similar volume of peritumoural normal breast tissue were collected for IL10 assay. IL10 expression was assayed by immunohistochemistry. IL10 expressing tumours and IL10 non expressing tumours were compared. Chi square/Fisher exact test and student's t test were used to compare the data. p-valueless than 0.05 was considered as statistically significant. Thirty six patients (60 %) of carcinoma breast showed IL 10 expression in tumour tissue as compared to no IL 10 expression in any peritumouralnormal breast tissue (p < 0.01). IL10 expression had statistically significant correlation with locally advanced disease, tumour grade, HER2 + ve tumours and ER-ve, PR-ve, HER2 + ve breast cancer subtypes (p = 0.001, 0.001, 0.001 and 0.01 respectively). No correlation could be found with patient's age, tumour size, tumour histology and ER and PR status. Correlation of IL10 expressing tumours with several established poor prognostic markers of breast cancer may indicate the possible association of IL10 expression with poor prognosis. Large studies with long term follow up are needed to substantiate the association of IL10 with poor prognosis.

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Cytokine Comparisons Between Women With Breast Cancer and Women With a Negative Breast Biopsy

Cited by 97 publications

References 26 publications

Breast Cancer Survival Is Associated with Telomere Length in Peripheral Blood Cells

Breast Cancer Survival Is Associated with Telomere Length in Peripheral Blood Cells

The Role of Interleukin-8 and Its Mechanism in Patients with Breast Cancer: Its Relation with Oxidative Stress and Estrogen Receptor

Is Interleukin 10 (IL10) Expression in Breast Cancer a Marker of Poor Prognosis?

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