Cytogenetic study of B-cell lymphoma of mucosa-associated lymphoid tissue

Wotherspoon, Andrew; Pan, Langxing; Diss, TC; Isaacson, Peter G.

doi:10.1016/0165-4608(92)90130-z

Cited by 170 publications

(75 citation statements)

References 20 publications

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“…6,[38][39][40] However, other reports show lower incidences of trisomy 3 in this type of NHL. 5,7,41,42 Furthermore, it is still not clear whether primary gastric large cell lymphoma originates from low-grade MALT lymphoma or that it arises de novo and is a separate entity. Some studies are supportive of a lymphomagenesis of high-grade MALT lymphoma from low-grade MALT lymphoma, eg by showing clonal relationship between low-and high-grade lymphoma cells.…”

Section: Discussionmentioning

confidence: 99%

“…Chromosomes 3, 7, 12 and 18 were included since these have been described to be aberrant in NHL in general and in gastric lymphomas in particular. [5][6][7][8]38,[46][47][48] Cytogenetic studies by Wotherspoon et al 5 and Ott et al 7 reported trisomy 3 in respectively 20% and 10% of gastric low-grade MALT lymphomas and in 21% of high-grade MALT lymphomas. 7 Using FISH on isolated nuclei of 10 gastric lowgrade MALT lymphomas, Ott et al 7 confirmed a relatively low incidence of trisomy 3 (10%).…”

Section: Discussionmentioning

confidence: 99%

“…Recurrent aberrations include trisomies of chromosomes 3, 12 and 18, and to a lesser extent of chromosome 7. [5][6][7][8] Furthermore, translocation t (11;18) and less frequently t(1;14), t(3;14), t (8;14) and t(14;18) have been identified. Aberrations involving MYC have so far been described in three studies on large cell lymphomas.…”

Section: Introductionmentioning

confidence: 99%

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Leukemia

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Gastric MALT lymphoma is a distinct entity related to Helicobacter pylori gastritis. Some studies suggest a role for trisomy 3 in the genesis of these lymphomas, but they mainly focused on low-grade MALT lymphoma. Gastric MALT lymphoma, however, comprises a spectrum from low-to high-grade cases. Furthermore, its exact relation to primary diffuse large B cell lymphoma (DLBCL) of the stomach is not clear. We applied in situ hybridisation (ISH) with centromeric probes on 43 samples of 39 patients with primary gastric lymphoma (13 samples with low-grade MALT lymphoma, 25 with high-grade MALT lymphoma and five with DLBCL) to detect numerical aberrations of 10 chromosomes. ISH was performed immunohistochemically on nuclei isolated from paraffin-embedded resection tissue and on whole paraffin sections using immunofluorescence. In six of 13 low-grade MALT lymphomas trisomy was detected (46%) and mostly involved chromosome 3 (33%). In high-grade MALT lymphomas, trisomies were found in 16 of 25 cases (64%), mainly involving chromosomes 12 and 18. Trisomy 3 was present in only 13% of these cases. Of five DLBCL, only one showed trisomy. Nine of the 16 aberrant high-grade MALT lymphomas (56%) showed trisomy of more than one chromosome per case vs two of six for low-grade cases. In lymphomas with separate low-and high-grade tumour components some trisomies were detected in both components, whereas others occurred only in the high-grade tumour cells. This supports the hypothesis that high-grade MALT lymphomas can develop from a low-grade type and that this progression is accompanied by the acquisition of more genetic aberrations. However, trisomy 3 probably does not play a major role in this progression.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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1999

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“…Twelve chromosomal regions showed differential expression at the 95% CL in all the three groups and were therefore considered to define the signature of the gastric MALT lymphoma: 1p33-p36.3 (k), 1q21-q24 (k), 3p13-p22 (k), 3q13 (m), 3q21-q23 (k), 4q12-q22 (m), 4q26-q27 (m), 6p21.2-p24 (k), 6q12-16 (m), 15q22-q26 (k), 18q21-q23 (m) and Xq21 (m). Because tri-or polysomy 3 or 18 or both are the most frequent karyotypic abnormalities in MALT lymphomas, [2][3][4]8 our findings of altered expression in 3p13-p22, 3q13, 3q21-q23 and 18q21-q23 in all three groups is intriguing. However, trisomy 3 and trisomy 18 were documented in only 1 and 2 of the t(11;18)(q21;q21)-negative cases respectively (data not shown), the 10 t(11;18)(q21;q21)-positive MALT lymphomas did not show any other genetic anomalies besides this translocation, and regions 3p13-p22 and 3q21-q23 were downregulated whereas all cytogenetic studies on MALT lymphomas report gain of material on chromosome 3.…”

Section: Discussionmentioning

confidence: 95%

“…Several genetic aberrations in MALT lymphomas have been described: aneuploidy, such as trisomy 3 and 18, [2][3][4] and chromosomal translocations, such as t(1;14)(p22;q32), t(14;18)(q32;q21), t(3;14)(3p13;q32) and t(11;18)(q21;q21). [5][6][7][8][9][10][11][12][13] The latter genetic anomaly was first described in 1989 14 and is the most common translocation in MALT lymphomas.…”

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confidence: 99%

Comparative expressed sequence hybridization studies of t(11;18)(q21;q21)-positive and -negative gastric MALT lymphomas reveal both unique and overlapping gene programs

et al. 2010

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Among the genetic abnormalities reported to occur in MALT lymphomas, the translocation t(11;18)(q21;q21) is of particular interest because it is exclusively documented in MALT lymphomas, mainly with gastrointestinal location. It results in the creation of a fusion protein API2-MALT1 that activates the transcription factor NF-jB through enhanced IKKc polyubiquitination. Here, we apply the recently developed molecular technique termed comparative expressed sequence hybridization to identify differentially expressed chromosomal regions related to the pathogenesis of gastric MALT lymphomas. By comparing t(11;18)(q21;q21)-positive gastric MALT lymphomas to their t(11;18)(q21;q21)-negative counterparts, we found that the location of the MALT1 break point determines a difference in expression pattern within the t(11;18)(q21;q21)-positive group. Moreover, we could define a gastric MALT lymphoma signature, which most likely comprises the regions and genes with significance in the development of MALT lymphomas, by comparing both t(11;18)(q21;q21)-positive and -negative MALT lymphomas to normal lymphoid tissue. Finally, a significant imprint of the marginal zone signature, established by comparing microdissected, splenic B follicles with and without marginal zone, was evident in the expression profile of MALT lymphoma, further supporting a marginal zone origin for this type of B-cell non-Hodgkin's lymphoma.

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