Cytodiagnosis of Inflammatory Dermatoses

Graham, James H.; Bingul, Ozdemir; Burgoon, Carroll B.

doi:10.1001/archderm.1963.01590130124020

Cited by 20 publications

(4 citation statements)

References 7 publications

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“…Dudgeon & Patrick (1927) found that basal cell carcinoma could be diagnosed accurately using cytology, and this has been confirmed by other observers (Urbach, Burke & Traenkle, 1957;Brown, Klaber & Robertson, 1979). In addition, cytological examination of bhsters, as introduced by Tzanck, is well recognized to be useful in the rapid demonstration of acantholytic epidermal cells in pemphigus and the viral inclusions of herpes (Graham, Bingul & Burgoon, 1963)-However, these studies have been based on cytological preparations obtained from tissue imprints or serapings. An alternative technique, fine needle aspiration cytology (FNAC), was introduced in the 1930s by Stewart (1933) and Martin and Ellis (1934) in the U.S.A.…”

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confidence: 85%

Fine needle aspiration cytology in dermatology: a clinicopathological appraisal

Slater

Reilly

1986

Br J Dermatol

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The possible clinical value of fine needle aspiration cytology (FNAC) has been assessed prospectively in 60 patients presenting with cutaneous lesions. The cytological diagnosis in each case has been compared with the clinical diagnosis and biopsy result. The principal potential use appears to be the rapid confirmation of the clinical diagnosis of basal cell carcinoma to allow immediate referral for radiotherapy or plastic surgery. FNAC could also prove useful when the clinical diagnosis of malignant melanoma is in doubt and primary diagnostic excision is difficult or disfiguring. Accurate distinction could usually be made between benign and malignant lymphoproliferative conditions, but further classification was difficult. Metastatic malignancy could be diagnosed with ease and other characteristic cytological appearances were seen with naevocellular naevi, pyogenic granuloma and pilar cysts. However, there were limitations in achieving an accurate diagnosis in approximately half the cases, and consequently, FNAC cannot be regarded in general as a substitute for histological diagnosis.

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confidence: 85%

Fine needle aspiration cytology in dermatology: a clinicopathological appraisal

Slater

Reilly

1986

Br J Dermatol

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“…Tzanck smear (a smear made by scrapped material from the floor and roof of an early, freshly opened blister) is an acceptable tool for diagnosis of blistering diseases 2 . The method has certain advantages as a rapid aid to the diagnosis of blistering diseases.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological correlation of blistering diseases of skin

Kabir

Kamal²,

Choudhury³

1970

Bangladesh Med Res Counc Bull

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Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin and Eosin stain, direct immunofluorescence test was done in 31 cases, indirect immunofluorescence in 28 cases and Tzanck smear in 33 cases. Direct immunofluorescence stain was also applied on Tzanck smears. The most frequent diagnoses were pemphigus (n=16), bullous pemphigoid (n=11) and linear IgA dermatosis (n=3). Clinical findings and histological examination were sufficient for the diagnosis of most cases. Direct immunofluorescence study is essential in many cases, and indirect immunofluorescence study is a useful method for diagnosis of some of the blistering diseases, especially in pemphigus. Direct immunofluorescence staining on Tzanck smear is a novel technique for the diagnosis of pemphigus.

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“…The cell circumference is usually smooth and round [1] but in our study some acantholytic cells have amoeboid-like cytoplasmic projections. Tzanck cells are not pathognomonic for PV since they can be seen in other vesiculobullous disorders, viral infections, impetigo and carcinomas [10].…”

Section: Discussionmentioning

confidence: 85%

“…Pemphigus vulgaris (PV) is a chronic autoimmune vesiculobullous disease of the skin and mucous membrane characterized by the loss of cell-cell adhesion mediated by autoantibodies to a cadherin-type adhesion molecule called desmoglein [1,2,3,4,5,6,7]. Desmoglein is a protein constituent of desmosome [2,5].…”

Section: Introductionmentioning

confidence: 99%

Pemphigus Vulgaris of Skin: Cytological Findings and Pitfalls

Mokhtari

Rasolmali²,

Kumar³

2012

Acta Cytologica

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Background: Pemphigus vulgaris (PV) is an autoimmune bullous lesion of the skin and mucous membranes characterized by suprabasal clefting and acantholysis. The responsible autoantibody is desmoglein 3, a protein constituent of the desmosome. The diagnosis of PV is based on histological examination and immunofluorescence study. In addition, cytological smears could also be informative for the initial diagnosis of PV. Cases: Fifteen patients, 7 men and 8 women, with skin bullous disease clinically suspected of being PV were selected for cytological study. The bullae were ruptured and two smears were prepared from the fluid and stained with the Wright-Giemsa and Papanicolaou methods. The smears were taken from both new and old bullae. They showed acantholytic cells (Tzanck cells), some with amoeboid-like cytoplasmic projections, eosinophils, basophils, various forms of typical and atypical lymphocytes with irregular nuclear borders and cerebriform nuclei and dysplastic acantholytic cells with a high nucleo-cytoplasmic ratio and prominent nucleoli. The dysplastic cells were seen only in the old bullae. Histological examination and immunofluorescence study of the lesions confirmed the diagnosis of PV. Conclusion: PV can be diagnosed by cytology. Without a clinical history of PV, the presence of atypical lymphocytes and dysplastic cells may lead to a false diagnosis of malignancy.

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Cytodiagnosis of Inflammatory Dermatoses

Cited by 20 publications

References 7 publications

Fine needle aspiration cytology in dermatology: a clinicopathological appraisal

Fine needle aspiration cytology in dermatology: a clinicopathological appraisal

Clinicopathological correlation of blistering diseases of skin

Pemphigus Vulgaris of Skin: Cytological Findings and Pitfalls

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