Cytocompatible drug delivery hydrogels based on carboxymethylagarose/chitosan pH-responsive polyelectrolyte complexes

Ortiz, J. Andrés; Sepúlveda, Francesca Antonella; Panadero-Medianero, Concepción; Murgas, Paola; Ahumada, Manuel; Palza, Humberto; Matsuhiro, Betty; Zapata, Paula Andrea

doi:10.1016/j.ijbiomac.2021.12.093

Cited by 24 publications

(9 citation statements)

References 96 publications

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“…The loading efficiency (LE%) of the drug in the dressing material is used to express the amount of the drug that is loaded per weight of the dressing materials and is calculated using following equation [ 203 , 205 ].

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Section: In Vitro Characterization Methods For Wound Dressing Materialsmentioning

confidence: 99%

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Ahmad

2022

Pharmaceutics

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Chronic wound management represents a major challenge in the healthcare sector owing to its delayed wound-healing process progression and huge financial burden. In this regard, wound dressings provide an appropriate platform for facilitating wound healing for several decades. However, adherent traditional wound dressings do not provide effective wound healing for highly exudating chronic wounds and need the development of newer and innovative wound dressings to facilitate accelerated wound healing. In addition, these dressings need frequent changing, resulting in more pain and discomfort. In order to overcome these issues, a wide range of affordable and innovative modern wound dressings have been developed and explored recently to accelerate and improve the wound healing process. However, a comprehensive understanding of various in vitro and in vivo characterization methods being utilized for the evaluation of different modern wound dressings is lacking. In this context, an overview of modern dressings and their complete in vitro and in vivo characterization methods for wound healing assessment is provided in this review. Herein, various emerging modern wound dressings with advantages and challenges have also been reviewed. Furthermore, different in vitro wound healing assays and in vivo wound models being utilized for the evaluation of wound healing progression and wound healing rate using wound dressings are discussed in detail. Finally, a summary of modern wound dressings with challenges and the future outlook is highlighted.

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Section: In Vitro Characterization Methods For Wound Dressing Materialsmentioning

confidence: 99%

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Ahmad

2022

Pharmaceutics

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“…The formation of hydrogen bonds, electrostatic and dipole-dipole interactions between the ionized amino and carboxyl groups of diclofenac sodium, and the charged centers of the polymer contributed to the macromolecular encapsulation of diclofenac sodium. At pH 6.0 and a temperature of 37 °C, approximately 67% of the drug was released, while at a temperature of 25 °C, only 40% of the drug was released in comparison [ 68 ]. According to the authors, this result can be explained by the increase in the mobility of polymer chains at a higher temperature.…”

Section: Gels In Ophthalmologymentioning

confidence: 99%

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

et al. 2023

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Modified polymeric gels, including nanogels, which play not only the role of a bioinert matrix, but also perform regulatory, catalytic, and transport functions due to the active fragments introduced into them, can significantly advance the solution to the problem of targeted drug delivery in an organism. This will significantly reduce the toxicity of used pharmaceuticals and expand the range of their therapeutic, diagnostic, and medical application. This review presents a comparative description of gels based on synthetic and natural polymers intended for pharmaceutical-targeted drug delivery in the field of therapy of inflammatory and infectious diseases, dentistry, ophthalmology, oncology, dermatology, rheumatology, neurology, and the treatment of intestinal diseases. An analysis was made of most actual sources published for 2021–2022. The review is focused on the comparative characteristics of polymer gels in terms of their toxicity to cells and the release rate of drugs from nano-sized hydrogel systems, which are crucial initial features for their further possible application in mentioned areas of biomedicine. Different proposed mechanisms of drug release from gels depending on their structure, composition, and application are summarized and presented. The review may be useful for medical professionals, and pharmacologists dealing with the development of novel drug delivery vehicles.

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“…Polyelectrolyte complexes (PECs) are formed by the electrostatic interaction between polymers of opposite charges 1 and can be used in a wide range of applications, such as controlled drug release, [2][3][4][5][6][7] flocculation processes in the textile industry, 8 enhancement of the strength of paper and cotton, 9,10 and heavy metal retention. [11][12][13] PECs are also useful materials as membrane additives due to characteristics such as hydrophilicity, chemical stability, anti-fouling properties, and the possibility of adjusting the surface charge.…”

Section: Introductionmentioning

confidence: 99%

Surface characterization and Remazol Red adsorption by asymmetric polyethersulfone membranes modified by polyelectrolyte complexes

da Silva Vale,

Bezerra da Silva,

Marcio Paranhos

et al. 2024

J of Applied Polymer Sci

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Polyethersulfone (PES) membranes containing 4‐fluorophenyl sulfone‐terminated poly(diallylpiperidinium hexafluorophosphate)‐sulfonated poly(ethylene terephthalate) polyelectrolyte complexes (PECs) were obtained via phase inversion using three different methods that enabled the complexation of polyelectrolytes (PELs) to occur before, after, and during membrane formation. Atomic force microscopy‐infrared spectroscopy analysis revealed varying concentrations of the polyanion depending on the preparation method and confirmed the presence of PECs in the membranes, highlighting an increase in surface roughness. Zeta potential measurements demonstrated positive surface charges for the membrane comprising PES and the polycation. The reduction in zeta potential in PEC membranes corresponded with the neutralization of positive groups by sulfonated poly(ethylene terephthalate. Scanning electron microscopy micrographs depicted surface imperfections in PEC membranes, emphasizing the influence of PECs on membrane surfaces. The water contact angle decreased, indicating increased hydrophilicity in PEC membranes. Additionally, dye adsorption results showcased significant adsorption, with the membranes absorbing at least 60% of Remazol Red from an aqueous solution. Notably, the Blend membrane outperformed others, exhibiting an exceptional adsorption rate exceeding 92%.

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Cytocompatible drug delivery hydrogels based on carboxymethylagarose/chitosan pH-responsive polyelectrolyte complexes

Cited by 24 publications

References 96 publications

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings

Polymeric Gel Systems Cytotoxicity and Drug Release as Key Features for their Effective Application in Various Fields of Addressed Pharmaceuticals Delivery

Surface characterization and Remazol Red adsorption by asymmetric polyethersulfone membranes modified by polyelectrolyte complexes

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