Cytidinediphosphocholine (CDP choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly

A parametric meta‐analysis

“…In summary, our analyses are consistent with the results reported in the work of Fioravanti and Yanagi for these endpoints, supporting a small but statistically significant treatment effect of citicoline on memory, behavioral, and memory recall.…”

A parametric meta‐analysis

“…In summary, our analyses are consistent with the results reported in the work of Fioravanti and Yanagi for these endpoints, supporting a small but statistically significant treatment effect of citicoline on memory, behavioral, and memory recall.…”

Neuroprotective agents in the management of glaucoma

“…Citicoline also showed efficacy in Alzheimer’s disease possibly interfering on the deposition of neurotoxic proteins such as β-amyloid, and improving mental performance and brain electrical activity. This was also in part confirmed in a Cochrane systematic review [45]. Moreover, citicoline showed a significant improvement of neurological signs and symptoms such as improvement of rigidity, bradykinesia and tremor in Parkinson’s disease [46–48].…”

Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function

“…Citicoline is an endogenous substance that acts as an intermediary in the synthesis of phosphatidylcholine (a major phospholipid in the neuronal membrane) through the activation of the biosynthesis of structural phospholipids in neuronal membranes, increases the metabolism of cerebral structures, inhibits phospholipid degradation and induces an increase in the levels of different neurotransmitters and neuromodulators, including noradrenaline in the Central Nervous System. In addition, a mechanism of dopamine-like action has also been supposed (see Fioravanti and Yanagi for a review [131]).…”

A parametric meta‐analysis

“…In summary, our analyses are consistent with the results reported in the work of Fioravanti and Yanagi for these endpoints, supporting a small but statistically significant treatment effect of citicoline on memory, behavioral, and memory recall.…”

Neuroprotective agents in the management of glaucoma

“…Citicoline also showed efficacy in Alzheimer’s disease possibly interfering on the deposition of neurotoxic proteins such as β-amyloid, and improving mental performance and brain electrical activity. This was also in part confirmed in a Cochrane systematic review [45]. Moreover, citicoline showed a significant improvement of neurological signs and symptoms such as improvement of rigidity, bradykinesia and tremor in Parkinson’s disease [46–48].…”

Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function

“…Citicoline is an endogenous substance that acts as an intermediary in the synthesis of phosphatidylcholine (a major phospholipid in the neuronal membrane) through the activation of the biosynthesis of structural phospholipids in neuronal membranes, increases the metabolism of cerebral structures, inhibits phospholipid degradation and induces an increase in the levels of different neurotransmitters and neuromodulators, including noradrenaline in the Central Nervous System. In addition, a mechanism of dopamine-like action has also been supposed (see Fioravanti and Yanagi for a review [131]).…”

A parametric meta‐analysis

“…In summary, our analyses are consistent with the results reported in the work of Fioravanti and Yanagi for these endpoints, supporting a small but statistically significant treatment effect of citicoline on memory, behavioral, and memory recall.…”

Neuroprotective agents in the management of glaucoma

“…Citicoline also showed efficacy in Alzheimer’s disease possibly interfering on the deposition of neurotoxic proteins such as β-amyloid, and improving mental performance and brain electrical activity. This was also in part confirmed in a Cochrane systematic review [45]. Moreover, citicoline showed a significant improvement of neurological signs and symptoms such as improvement of rigidity, bradykinesia and tremor in Parkinson’s disease [46–48].…”

Citicoline and Retinal Ganglion Cells: Effects on Morphology and Function

“…Citicoline is an endogenous substance that acts as an intermediary in the synthesis of phosphatidylcholine (a major phospholipid in the neuronal membrane) through the activation of the biosynthesis of structural phospholipids in neuronal membranes, increases the metabolism of cerebral structures, inhibits phospholipid degradation and induces an increase in the levels of different neurotransmitters and neuromodulators, including noradrenaline in the Central Nervous System. In addition, a mechanism of dopamine-like action has also been supposed (see Fioravanti and Yanagi for a review [131]).…”