Cytidine 5&amp;rsquo;-diphosphocholine administration prevents peripheral neuropathic pain after sciatic nerve crush injury in rats

Emril, Dessy Rakhmawati; Wibowo, Samekto; Meliala, Lucas; Susilowati, Rina

doi:10.2147/jpr.s70481

Cited by 18 publications

(16 citation statements)

References 22 publications

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“…In the EPT test, the groups receiving citicoline had a significantly lower percentage of a motor deficit than in the control group: for 0.4 and 0.8 mL, respectively, 14.28% and 20.6% ( p = 0.00). Citicoline in this test was effective in alleviating neuropathic pain and reducing motor deficit [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.

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Section: Resultsmentioning

confidence: 99%

Application of Citicoline in Neurological Disorders: A Systematic Review

et al. 2020

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“…Previous studies have shown that sciatic nerve crush induces chronic neuropathic pain, 25 – 28 and axon regeneration plays a pivotal role in the maintenance of neuropathic pain. 29 , 30 With the development of in vitro miRNAs synthesis and delivery technology, those small nucleotide sequences have been deemed as a promising approach for gene therapies.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-9 regulates mammalian axon regeneration in peripheral nerve injury

Jiang

Zhang

et al. 2017

Mol Pain

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Effective axon regeneration is achieved mainly by precise regulation of gene expression after peripheral nerve injury. MicroRNAs play an important role in controlling axon regeneration owe to its key epigenetic function in regulating gene expression. Here, we reveal that microRNA-9 (miR-9) may be a new suppressor of axon regeneration and FoxP1 is the functional target of miR-9. High level of endogenous miR-9 in sensory neurons inhibited axon regeneration in vitro and in vivo. In addition, the regulatory effect of miR-9 was mediated by changes in FoxP1 levels. Full rescuing effect of axon regeneration was achieved by FoxP1 up-regulation. Most importantly, we showed that miR-9-FoxP1 might be a new signaling pathway to regulate mammalian axon regrowth. Moreover, we provided the first evidence that maintaining a higher level of FoxP1 in sensory neurons by the microRNA is necessary for efficient axon regeneration.

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“…SFI analysis did not show significant differences between the three groups. From this study, it can be concluded temporarily that citicoline has the potential to help the recovery of peripheral nerves through its mechanism to help regenerate axons [17].…”

Section: Pathology Of Painful Diabetic Polyneuropathy Evidence Of Citicoline Effectiveness On Peripheral Nerve Lesion and Their Suggestedmentioning

confidence: 82%

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2021

Ro J Neurol.

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The purpose of this paper is to review the effectiveness of citicoline as suggested adjuvant therapy for painful diabetic polyneuropathy based on evidences. Pain is one of the most common symptoms that make patients consult with a doctor, especially chronic pain. One of the examples is painful diabetic polyneuropathy, which prevalence is increasing by global development. Diabetic polyneuropathy is the most common cause of neuropathic pain caused by long-term complications of microangiopathy. Affect not only individual socioeconomic status but also the psychological aspect of the patient. Neuropathic pain is one of the most common causes of long-term disability. Some medicines already recommended as the drug of choice, but not all of them give maximum results. Adjuvant neuroprotector therapy is often considered to help manage painful diabetic polyneuropathy, such as citicoline, which has been proven in some studies. Painful diabetic polyneuropathy is very challenging because of its pathophysiology, which has not fully understood. The different mechanism of pain sensation is still unknown but it is thought that the oxidative stress after microangiopathy triggers the discharge of abnormal load from damaged neurons. Some analgetics have not given the expected result. Conclusion.Citicoline may be suggested as adjuvant therapy based on evidences with animal subject, but further studies with human subject are still needed.

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Cytidine 5’-diphosphocholine administration prevents peripheral neuropathic pain after sciatic nerve crush injury in rats

Cited by 18 publications

References 22 publications

Application of Citicoline in Neurological Disorders: A Systematic Review

Application of Citicoline in Neurological Disorders: A Systematic Review

MicroRNA-9 regulates mammalian axon regeneration in peripheral nerve injury

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