Cystic Fibrosis in Asian Indians

Characterization of Pseudomonas aeruginosa isolated from chronically infected children with cystic fibrosis in India

“…In our study, we have followed all 56 patients attending the Pediatric Chest Clinic at All India Institute Of Medical Sciences, New Delhi, INDIA between August 1998-August 2001. The median age of diagnosis of patients was 4.5 years, which was much higher than what was earlier reported in the literature where the median age was found as 6 and 12 months among Caucasian American and Indian American children respectively [17]. This may be due to delayed diagnosis of CF patients in India.…”

Identification and Characterization of CFTR Gene Mutations in Indian CF Patients

“…The most common CF mutation worldwide is the deletion of a phenylalanine residue at position 508. A review of all genotyped South Asian patients shows that delta F508 is identified in 19% to 44% of CF alleles (Bowlers et al, 1993; Curtis et al, 1993; Powers et al, 1996; Kabra et al, 2000; Mei‐Zahav et al, 2005), considerably lower than the reported frequency of 66% in the worldwide CF population studied so far. Nevertheless, it is still the predominant mutation in Asian CF patients (Rawashdeh & Manal 2000).…”

The prevalence and clinical characteristics of cystic fibrosis in South Asian Canadian immigrants

“…While the US survey found only 20 patients of South Asian descent in the whole US population (248 709 873), 11 we identified 15 children of the same ethnic origin in a population that was 50-fold smaller. In fact, the prevalence of CF among young South Asians living in Metropolitan Toronto was higher than all other previous estimates and similar to that observed in the age matched general population.…”