Cystic appearance on magnetic resonance imaging in bihormonal growth hormone and prolactin tumors in acromegaly

Varlamov, Elena V.; Wood, Matthew D.; Netto, João Prola; Thiessen, Jaclyn; Kim, Jung; Lim, Dawn Shao Ting; Yedinak, Christine G.; Banskota, Swechya; Cetas, Justin S.; Fleseriu, Maria

doi:10.1007/s11102-020-01075-7

Cited by 10 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because mammosomatotroph PitNETs are usually densely granulated tumors, they generally have low intensity on T2-weighted MRI images [20]. However, this finding has not been evaluated in other series [4,95,96,104,105,110] and other authors found a similar proportion of hypointensity, isointensity and hyperintensity in T2-MRI sequence in GH-PRL-secreting PitNETs [109]. These differences may be justified by the proportion of densely granulated tumors, which varies across studies.…”

Section: Radiological Featuresmentioning

confidence: 94%

“…Another interesting finding of the study of Varlamov et al [ 109 ] was that GH- and PRL-secreting PitNETs more frequently had a cystic component on MRI than sparsely granulated GH PitNETs and densely granulated GH PitNETs (52.6% vs. 14.3% and 22%, p = 0.005 and 0.033, respectively). In addition, as an important point, they detected that cystic tumors in patients with acromegaly had lower rates of biochemical remission after surgery, regardless of histological subtype.…”

Section: Clinical Aspects and Outcomes Of Gh–prl Pitnetsmentioning

confidence: 97%

“…Nonetheless, other studies comparing patients with PitNETs with positive staining only for GH and those with positive GH and PRL staining were not able to demonstrate differences in tumor size and the rates of cavernous sinus invasion between both groups, despite the greater degree of IGF1 elevation in patients with GH–PRL PitNETs [ 95 ]. Conversely, some authors [ 109 ] found that PitNETs secreting GH and PRL were less frequently invasive (15.8% vs. 57.1%, p = 0.005) than PitNETs that only secreted GH, despite higher IGF1 indexes (3.3 vs. 2.3, p = 0.040) in the former [ 109 ]. Differences across studies would be explained by the different proportions of densely and sparsely granulated somatotroph tumors that have been included in each study in the control group (GH-secreting PitNETs).…”

Section: Clinical Aspects and Outcomes Of Gh–prl Pitnetsmentioning

confidence: 99%

“…Differences across studies would be explained by the different proportions of densely and sparsely granulated somatotroph tumors that have been included in each study in the control group (GH-secreting PitNETs). For example, in the Varlamov study, 50% of the patients in the control group had sparsely granulated GH PitNETs [ 109 ], whereas, in the Liang study [ 4 ], 66% of the tumors were sparsely granulated. This information is not available in other series [ 95 ].…”

Section: Clinical Aspects and Outcomes Of Gh–prl Pitnetsmentioning

confidence: 99%

See 3 more Smart Citations

Prolactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature

Araujo-Castro,

Marazuela,

Puig-Domingo

et al. 2023

IJMS

View full text Add to dashboard Cite

Prolactin (PRL) and growth hormone (GH) are peptide hormones that bind to the class 1 cytokine receptor superfamily, a highly conserved cell surface class of receptors. Both hormones control their own secretion via a negative autocrine loop in their own mammosomatotroph, lactotroph or somatotroph. In this regard, GH and PRL are regulated by similar signaling pathways involving cell growth and hormone secretion. Thus, GH and PRL dysregulation and pituitary neuroendocrine tumor (PitNET) development may have common pathogenic pathways. Based on cell linage, lactotroph and somatotroph PitNETs come from pituitary-specific POU-class homeodomain transcription factor (Pit-1). Mammosomatotroph and plurihormonal PitNETs are a unique subtype of PitNETs that arise from a single-cell population of Pit-1 lineage. In contrast, mixed somatotroph–lactotroph PitNETs are composed of two distinct cell populations: somatotrophs and lactotrophs. Morphologic features that distinguish indolent PitNETs from locally aggressive ones are still unidentified, and no single prognostic parameter can predict tumor aggressiveness or treatment response. In this review, we aim to explore the latest research on lactotroph and somatotroph PitNETs, the molecular mechanisms involved in PRL and GH axis regulation and the signaling pathways involved in their aggressiveness, particularly focused on mammosomatotroph and mixed subtypes. Finally, we summarize epidemiological, clinical, and radiological features of these exceptional tumors. We aim to shed light, from basic to clinical settings, on new perspectives and scientific gaps in this field.

show abstract

Section: Radiological Featuresmentioning

confidence: 94%

Section: Clinical Aspects and Outcomes Of Gh–prl Pitnetsmentioning

confidence: 97%

Section: Clinical Aspects and Outcomes Of Gh–prl Pitnetsmentioning

confidence: 99%

Section: Clinical Aspects and Outcomes Of Gh–prl Pitnetsmentioning

confidence: 99%

See 2 more Smart Citations

Prolactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature

Araujo-Castro,

Marazuela,

Puig-Domingo

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Measuring ranges were 3 -1,500 ng/ml for IGF-1, and 0.05 -80 ng/ml for GH, respectively. At OHSU, the majority of GH and IGF-1 were measured as previously published (24). Growth hormone values that were below the detection limit were reported as the lower limit of normal and the values that were above the assay reading capacity were reported as the maximum reading capacity (for example, GH >100 ng/ml was reported as 100 ng/ml).…”

Section: Biochemical Evaluationmentioning

confidence: 99%

Clinical features and complications of acromegaly at diagnosis are not all the same: data from two large referral centers

Varlamov

Niculescu

Banskota

et al. 2021

Endocrine Connections

Self Cite

View full text Add to dashboard Cite

Purpose: The number of international acromegaly-related registries is increasing; however, heterogeneity of acromegaly symptoms and signs across countries is not well described. We compared clinical disease manifestations at diagnosis between two large University referral centers from two continents. Methods: Retrospective, comparative epidemiological study of acromegaly patients at two centers; 1) C. I. Parhon National Institute of Endocrinology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania (Parhon), and 2) Pituitary Center, Oregon Health & Science University, Portland, Oregon, United States (OHSU) from approved registries was undertaken. Data were extracted from medical charts and questionnaires. Binary logistic regression analysis was undertaken for the most frequently noted symptoms and clinical signs. Results: Study included 216 patients (87 Parhon, 129 OHSU). Age, sex and median delay in diagnosis were similar between centers. IGF-1 index was higher in patients at Parhon (3.3 vs 2.1, p < 0.001). The top five symptoms at both centers were; enlarged hands/feet, headache, arthralgia, fatigue, and irregular menses in women. A significant difference was noted for multiple signs and symptoms frequency, often >20 percentage points between centers. Center was a predictor of many signs and symptoms, independent of acromegaly biochemical severity or disease duration. Conclusion: We show in the first comparative study that differences in medical practice, documentation, and likely cultural differences can influence patients’ symptom(s) reporting and screening patterns in geographically different populations. Pooling data into large multicenter international registries databases may lead to loss of regional characteristics and thus a mixed overall picture of combined cohorts.

show abstract

Preface: Pituitary Tumors Are More Frequent Than Previously Thought

Fleseriu

2022

A Case-Based Guide to Clinical Endocrinology

View full text Add to dashboard Cite

Cystic appearance on magnetic resonance imaging in bihormonal growth hormone and prolactin tumors in acromegaly

Cited by 10 publications

References 29 publications

Prolactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature

Prolactin and Growth Hormone Signaling and Interlink Focused on the Mammosomatotroph Paradigm: A Comprehensive Review of the Literature

Clinical features and complications of acromegaly at diagnosis are not all the same: data from two large referral centers

Preface: Pituitary Tumors Are More Frequent Than Previously Thought

Contact Info

Product

Resources

About