2012
DOI: 10.18632/aging.100491
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Abstract: Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine through the reverse transsulfuration pathway thereby modulating intracellular methionine availability. Whereas previous results obtained in yeast and fruit flies suggest that alterations in the rever… Show more

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Cited by 21 publications
(11 citation statements)
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References 24 publications
(39 reference statements)
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“…These findings suggest a protective mechanism in which the accumulation of toxic Hcy metabolites such as Hcy-thiolactone and N -Hcy-protein up-regulates the expression of genes involved in the removal of Hcy via trans-methylation and trans-sulfuration pathways that prevent the accumulation of these toxic metabolites. That CBS is important for maintaining endothelial cell homeostasis is supported by findings showing that reduction in CBS expression induces premature senescence in HUVECs (Albertini et al 2012 ).…”
Section: Discussionmentioning
confidence: 88%
“…These findings suggest a protective mechanism in which the accumulation of toxic Hcy metabolites such as Hcy-thiolactone and N -Hcy-protein up-regulates the expression of genes involved in the removal of Hcy via trans-methylation and trans-sulfuration pathways that prevent the accumulation of these toxic metabolites. That CBS is important for maintaining endothelial cell homeostasis is supported by findings showing that reduction in CBS expression induces premature senescence in HUVECs (Albertini et al 2012 ).…”
Section: Discussionmentioning
confidence: 88%
“…In fact, the current study represents the first investigation into the putative effects of Meth-R on human cells for the purpose of ameliorating age-related phenotypes. Notably, our discovery of the beneficial effects of Meth-R on human cell replicative lifespan is supported by a recent study demonstrating that depletion of cystathionine beta synthase, a manipulation predicted to increase intracellular methionine levels, reduces the lifespan of cultured human endothelial cells [58]. Given the low methionine content of the vegan diet [59], dietary Meth-R is a conceivable strategy for promoting healthy aging in humans.…”
Section: Discussionmentioning
confidence: 95%
“…Abnormal wing development has been found to occur when normal cell proliferation pathways are mutated ( Herranz and Milan 2008 ). Additionally, altered levels of enzymes controlling methionine metabolism can affect cell proliferation in human cells ( Hermes et al 2008 ; Albertini et al 2012 ). For these reasons, we decided to determine whether methionine metabolic enzymes, histone methyltransferases and demethylases contribute to regulation of cell proliferation in Drosophila .…”
Section: Resultsmentioning
confidence: 99%
“…Stable overexpression of AHCY induces cell death by apoptosis in human cells ( Hermes et al 2008 ). Reduction of CBS induces premature senescence in human endothelial cells ( Albertini et al 2012 ).…”
mentioning
confidence: 99%