Cystathionine beta-Synthase in hypoxia and ischemia/reperfusion: A current overview

Omorou, Moussa; Liu, Ning; Huang, Yiwei; Al-Ward, Hisham; Gao, Meng; Mu, Chenxi; Zhang, Lin; Xu, Hui

doi:10.1016/j.abb.2022.109149

Cited by 8 publications

(7 citation statements)

References 83 publications

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“…46 CBS acts through regulation of hydrogen sulfide generation and homocysteine metabolism during hypoxia. 47 Hypoxia is often associated with severe anaphylactic shock. 48 Collectively, these studies suggest that progression to mild disease phenotype is linked with a dominant innate inflammatory immune activation and transition to severe phenotype is associated with cell catabolism and stress response.…”

Section: Discussionmentioning

confidence: 99%

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Acute systemic myeloid inflammatory and stress response in severe food allergic reactions

Sharma

Rijavec

Tomar

et al. 2023

Clin Experimental Allergy

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Introduction: Food allergic reactions can be severe and potentially life-threatening and the underlying immunological processes that contribute to the severity of reactions are poorly understood. The aim of this study is to integrate bulk RNA-sequencing of human and mouse peripheral blood mononuclear cells during food allergic reactions and in vivo mouse models of food allergy to identify dysregulated immunological processes associated with severe food allergic reactions.Methods: Bulk transcriptomics of whole blood from human and mouse following food allergic reactions combined with integrative differential expressed gene bivariate and module eigengene network analyses to identify the whole blood transcriptome associated with food allergy severity. In vivo validation immune cell and gene expression in mice following IgE-mediated reaction.Results: Bulk transcriptomics of whole blood from mice with different severity of food allergy identified gene ontology (GO) biological processes associated with innate and inflammatory immune responses, dysregulation of MAPK and NFkB signalling and identified 429 genes that correlated with reaction severity. Utilizing two independent human cohorts, we identified 335 genes that correlated with severity of peanutinduced food allergic reactions. Mapping mouse food allergy severity transcriptome onto the human transcriptome revealed 11 genes significantly dysregulated and correlated with severity. Analyses of whole blood from mice undergoing an IgE-mediated reaction revealed a rapid change in blood leukocytes particularly inflammatory monocytes (Ly6C hi Ly6G − ) and neutrophils that was associated with changes in CLEC4E, CD218A and GPR27 surface expression.Conclusions: Collectively, IgE-mediated food allergy severity is associated with a rapid innate inflammatory response associated with acute cellular stress processes and dysregulation of peripheral blood inflammatory myeloid cell frequencies.

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Section: Discussionmentioning

confidence: 99%

“…ECHDC3 is a mitochondrial enzyme that is thought to be involved in β‐oxidation pathway of fatty acid metabolism 46 . CBS acts through regulation of hydrogen sulfide generation and homocysteine metabolism during hypoxia 47 . Hypoxia is often associated with severe anaphylactic shock 48 .…”

Section: Discussionmentioning

confidence: 99%

Acute systemic myeloid inflammatory and stress response in severe food allergic reactions

Sharma

Rijavec

Tomar

et al. 2023

Clin Experimental Allergy

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“…However, in certain types of cells, it can be localized in the nucleus [ 103 ] and mitochondria [ 104 ]. CBS expression is controlled by various extracellular and intracellular mechanisms in normal and pathological conditions [ 105 ].…”

Section: Metabolism and Functions Of H 2 Smentioning

confidence: 99%

The Role of Hydrogen Sulfide in Regulation of Cell Death following Neurotrauma and Related Neurodegenerative and Psychiatric Diseases

Rodkin

Nwosu

Sannikov

et al. 2023

IJMS

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Injuries of the central (CNS) and peripheral nervous system (PNS) are a serious problem of the modern healthcare system. The situation is complicated by the lack of clinically effective neuroprotective drugs that can protect damaged neurons and glial cells from death. In addition, people who have undergone neurotrauma often develop mental disorders and neurodegenerative diseases that worsen the quality of life up to severe disability and death. Hydrogen sulfide (H2S) is a gaseous signaling molecule that performs various cellular functions in normal and pathological conditions. However, the role of H2S in neurotrauma and mental disorders remains unexplored and sometimes controversial. In this large-scale review study, we examined the various biological effects of H2S associated with survival and cell death in trauma to the brain, spinal cord, and PNS, and the signaling mechanisms underlying the pathogenesis of mental illnesses, such as cognitive impairment, encephalopathy, depression and anxiety disorders, epilepsy and chronic pain. We also studied the role of H2S in the pathogenesis of neurodegenerative diseases: Alzheimer’s disease (AD) and Parkinson’s disease (PD). In addition, we reviewed the current state of the art study of H2S donors as neuroprotectors and the possibility of their therapeutic uses in medicine. Our study showed that H2S has great neuroprotective potential. H2S reduces oxidative stress, lipid peroxidation, and neuroinflammation; inhibits processes associated with apoptosis, autophagy, ferroptosis and pyroptosis; prevents the destruction of the blood-brain barrier; increases the expression of neurotrophic factors; and models the activity of Ca2+ channels in neurotrauma. In addition, H2S activates neuroprotective signaling pathways in psychiatric and neurodegenerative diseases. However, high levels of H2S can cause cytotoxic effects. Thus, the development of H2S-associated neuroprotectors seems to be especially relevant. However, so far, all H2S modulators are at the stage of preclinical trials. Nevertheless, many of them show a high neuroprotective effect in various animal models of neurotrauma and related disorders. Despite the fact that our review is very extensive and detailed, it is well structured right down to the conclusions, which will allow researchers to quickly find the proper information they are interested in.

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“…These hypoxia conditions lead to the proliferation, angiogenesis, metastasis, metabolism reprogramming, stemness, immune evasion, and therapy resistance of tumor cells, and ultimately contribute to tumor progression [ 14 , 20 , 87 , 88 ]. During surgical operation or drug treatment in some organs, ischemia/reperfusion (I/R) results in the hypoxia/reoxygenation (H/R) of cells because of the changes in oxygen supply from the bloodstream, which finally leads to cell death and injury [ 16 , 89 ]. Moreover, hypoxic placenta resulting from the dysregulation of angiogenic factors, induces oxidative stress, lipid peroxidation, endothelial dysfunction, and peripheral vasoconstriction, leading to abnormal trophoblastic invasion and preeclampsia, which is a serious and distinct type of pregnancy-induced hypertension [ 13 ].…”

Section: Hypoxia and Hypoxia-induced Factorsmentioning

confidence: 99%

Ferroptosis Regulated by Hypoxia in Cells

Zheng

Liang

Zhang

2023

Cells

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Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, and immunologically distinct from other regulated cell death forms. Ferroptosis is regulated by iron metabolism, lipid metabolism, anti-oxidant defense systems, as well as various signal pathways. Hypoxia, which is found in a group of physiological and pathological conditions, can affect multiple cellular functions by activation of the hypoxia-inducible factor (HIF) signaling and other mechanisms. Emerging evidence demonstrated that hypoxia regulates ferroptosis in certain cell types and conditions. In this review, we summarize the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in physiological and pathological conditions, which may contribute to the numerous diseases therapies.

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Cystathionine beta-Synthase in hypoxia and ischemia/reperfusion: A current overview

Cited by 8 publications

References 83 publications

Acute systemic myeloid inflammatory and stress response in severe food allergic reactions

Acute systemic myeloid inflammatory and stress response in severe food allergic reactions

The Role of Hydrogen Sulfide in Regulation of Cell Death following Neurotrauma and Related Neurodegenerative and Psychiatric Diseases

Ferroptosis Regulated by Hypoxia in Cells

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