Cyr61, a Matricellular Protein, Is Needed for Dendritic Arborization of Hippocampal Neurons

Malik, Anna R.; Urbańska, Małgorzata; Gozdz, Agata; Swiech, Lukasz; Nagalski, Andrzej; Perycz, Małgorzata; Błażejczyk, Magdalena; Jaworski, Jacek

doi:10.1074/jbc.m112.411629

Cited by 41 publications

(39 citation statements)

References 70 publications

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“…DEGs detected only in ganglia from non-reactivated animals also enriched to biological and disease processes related to metabolism, cell adhesion, central nervous diseases, and viral infections. Genes that enriched to “central nervous system diseases” and “viral infection” were primarily up-regulated and played a role in neuron growth such as NGF (FC 7, regulates neuron growth) (Indo et al , 1996), DSC1 (FC 95, neural circuit regulation (Zhang et al , 2013)), and CYR61 (FC 6, dendrite growth (Malik et al , 2013)) (Fig. 9d).…”

Section: Resultsmentioning

confidence: 99%

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

et al. 2017

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Section: Resultsmentioning

confidence: 99%

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

et al. 2017

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“…Within the mPFC, Btg2 expression was reduced, and previous findings have shown Btg2 involvement in neurite outgrowth (106) and histone H4 arginine methylation and acetylation processes (107). Similarly, Cyr61 expression was also reduced in SNI and CUS groups of mice, and its activity is critical for dendritic growth in hippocampal neurons (108). Within the NAc, Ccl3 was enhanced in SNI and CUS groups, and its protein product, the pro-inflammatory cytokine, Ccl3, is known to enhance inflammatory responses within the CNS and increases Ca 2+ signaling in cultured neurons (109–110).…”

Section: Discussionmentioning

confidence: 99%

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

et al. 2017

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Neuropathic pain is a complex chronic condition characterized by a wide range of sensory, cognitive, and affective symptoms. A large percentage of neuropathic pain patients are also afflicted with depression and anxiety disorders – a pattern that is reliably replicated in animal models. Furthermore, clinical and preclinical studies indicate that chronic pain corresponds with adaptations in several brain networks involved in mood, motivation, and reward. Chronic stress is also a major risk factor for depression. We investigated whether chronic pain and stress affect similar mechanisms, and whether chronic pain can affect gene expression patterns known to be involved in depression. Using two mouse models for neuropathic pain and depression (spared nerve injury (SNI) and chronic unpredictable stress (CUS)) we performed next generation RNA-sequencing and pathway analysis to monitor changes in gene expression in the nucleus accumbens (NAc), the medial prefrontal cortex (mPFC), and the periaqueductal grey (PAG). These three brain regions are implicated in the pathophysiology of depression and in the modulation of pain. In addition to finding unique transcriptome profiles across the three brain regions,.we identified a substantial number of signaling pathway-associated genes with similar changes in expression in both SNI and CUS mice. Many of these genes have been implicated in depression, anxiety and chronic pain in patients. Our study provides a resource of the changes in gene expression induced by long-term neuropathic pain in three distinct brain regions and reveals molecular connections between pain and chronic stress.

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“…4 and Table 2). CYR61 was more abundant in secretomes of both cell types after FTY720P treatment and formerly shown to be essential for dendritic development of CNS neurons (64). CYR61 is a downstream target of Smad as well as of c‐Jun (65).…”

Section: Discussionmentioning

confidence: 99%

Secretome analysis of nerve repair mediating Schwann cells reveals Smad‐dependent trophism

et al. 2018

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Schwann cells promote nerve regeneration by adaptation of a regenerative phenotype referred to as repair mediating Schwann cell. Down‐regulation of myelin proteins, myelin clearance, formation of Bungner's bands, and secretion of trophic factors characterize this cell type. We have previously shown that the sphingosine‐1‐phosphate receptor agonist Fingolimod/FTY720P promotes the generation of this particular Schwann cell phenotype by activation of dedifferentiation markers and concomitant release of trophic factors resulting in enhanced neurite growth of dorsal root ganglion neurons. Despite its biomedical relevance, a detailed characterization of the corresponding Schwann cell secretóme is lacking, and the impact of FTY720P on enhancing neurite growth is not defined. Here, we applied a label‐free quantitative mass spectrometry approach to characterize the secretomes derived from primary neonatal and adult rat Schwann cells in response to FTY720P. We identified a large proportion of secreted proteins with a high overlap between the neonatal and adult Schwann cells, which can be associated with biologic processes such as development, axon growth, and regeneration. Moreover, FTY720P‐treated Schwann cells release proteins downstream of Smad signaling known to support neurite growth. Our results therefore uncover a network of trophic factors involved in glial‐mediated repair of the peripheral nervous system.—Schira, J., Heinen, A., Poschmann, G., Ziegler, B., Hartung, H.‐P., Stühler, K., Küry, P. Secretome analysis of nerve repair mediating Schwann cells reveals Smad‐dependent trophism. FASEB J. 33, 4703–4715 (2019). http://www.fasebj.org

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Cyr61, a Matricellular Protein, Is Needed for Dendritic Arborization of Hippocampal Neurons

Cited by 41 publications

References 70 publications

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

Neuropathic pain promotes adaptive changes in gene expression in brain networks involved in stress and depression

Secretome analysis of nerve repair mediating Schwann cells reveals Smad‐dependent trophism

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