Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress

Kou, Mei-Chun; Yen, Jui-Hung; Hong, Jing-Ting; Wang, Chia‐Ling; Lin, Ching-Yi; Wu, Ming-Jiuan

doi:10.1016/j.lwt.2008.09.010

Cited by 44 publications

(20 citation statements)

References 25 publications

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“…Previous work done by Kou et al (15) found that the EA fraction of tamarillo displayed the highest TPC of 61.1 mg (CE)/g DW which was in contrast with the present study. Nevertheless, a study done by Vasco et al (25) reported that the TPC values were 1.25 and 1.87 mg GAE/g FW in golden-yellow and purple-red tamarillo varieties respectively, which concurs with the present study.…”

Section: Total Phenolic Contentcontrasting

confidence: 99%

“…The n-butanol layer was evaporated at 60 °C and liquefied in DMSO and signified as the n-butanol fraction. Finally, the water layer was freeze dried and liquefied in DMSO and signified as water fraction (15). These supernatants were later employed for the quantification of total phenolic content (TPC), total flavonoid content (TFC), β-carotene bleaching (BCB) and diphenylpicrylhydrazyl (DPPH) radical scavenging assays.…”

Section: Sample Preparationmentioning

confidence: 99%

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Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

Mutalib

Rahmat

Ali

et al. 2017

MJMS

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Background: This study aims to examine various solvent extracts of Cyphomandra betacea (tamarillo) also known as the tree tomato, for their bioactive constituents and antioxidant activity. The study also aims to examine its effect on cancer cell death using two types of cancer cell lines (liver and breast cancer cell).Methods: The first part of the study evaluates the nutritional composition of tamarillo. Then, phytochemical profiling using GC-MS analysis in ethanolic tamarillo extract was conducted. Different fractions of n-butanol, ethyl acetate and aqueous fractions were obtained from the ethanolic extract of tamarillo. Then, the fractions were subjected to the quantification of total phenol (TPC) and flavonoid contents (TFC), free radical scavenging activity (SA) and also antioxidant activity (AOX) assayed by beta-carotene bleaching (BCB) assay. Finally, the capability of the ethanolic extract of tamarillo and different fractions were evaluated for their anticancer properties.Results: Findings from this study revealed that the nutritional composition (ash, protein, carbohydrate and total dietary fiber), and mineral levels (calcium, magnesium, potassium and iron) of tamarillo were moderate. The crude ethanol extract of tamarillo contained the highest phenolic and total flavonoid content. FT-IR analysis revealed the presence of alkanes, carboxylic acid, phenol, alkanes, carboxylic acids, aromatics and nitro compounds. Twelve bioactive constituents in tamarillo have been identified through GC-MS analysis. Cytotoxic activity suggests the potential of ethanolic extracts of tamarillo having a chemopreventive effect on breast and liver cancer cells.Conclusion: This study reveals that tamarillo has substantial antioxidant activity as well as anticancer properties.

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Section: Total Phenolic Contentcontrasting

confidence: 99%

Section: Sample Preparationmentioning

confidence: 99%

Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

Mutalib

Rahmat

Ali

et al. 2017

MJMS

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“…Due to the possible hazardous effect of synthetic antioxidants, there is an increasing interest in natural antioxidants such as those in fruits and vegetables (Frankel, 2007;Hossain & Rahman, 2010). Epidemiological studies have shown that an increase in fruit intake is associated with a reduced morbidity of cardiovascular disease, some types of cancer, and neurodegenerative diseases (Guo et al, 2003;Reddy, Sreermulu & Raghunath, 2010;Moure et al, 2001;Lima, Pimenta & Boaventura, 2010;Kou et al, 2009). A possible mechanism for this observation has been attributed to the antioxidant activity in fruits (Guo et al, 2003, Moure et al, 2001, Kou et al, 2009.…”

Section: Antioxidantsmentioning

confidence: 99%

A Comparative Study of the Antioxidant Properties of Three Pineapple (Ananas comosus L.) Varieties

Yuris

Siow

2014

Journal of Food Studies

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The objective of this study was to determine the antioxidant activity of different pineapple varieties namely Josephine (Ananas comosus L. var. comosus cv. Josephine), Morris (Ananas comosus L. var. comosus cv. Morris), and Sarawak (Ananas comosus L. var. comosus cv. Sarawak). Different concentrations of methanol, ethanol, and acetone were used to extract the phenolic compounds. Folin Ciocalteu's reagent was used to determine the total phenolic content. The ascorbic acid content of the fruit extracts was determined using the iodine titration method. The antioxidant activity of the pineapples was measured using the 2,2-diphenyl-1-picryhydrzyl (DPPH) radical scavenging assay, the Ferric Reducing Power (FRP) assay and the Ferrous Ion Chelating (FIC) assay. 50% methanol was chosen as the best solvent for extracting the phenolic compounds of the pineapples. Morris pineapple was found to contain the highest TPC (53.8±0.7 mg GAE/100g fruits) and antioxidant activity. This variety was also found to have the highest DPPH scavenging activity (25.2±0.5 mg AA/100g fruits), FRP (29.6 mg GAE/100g fruits) and FIC ability (8%/100g fruits). Despite having a higher TPC than the Sarawak variety, Josephine exhibited a low scavenging activity. Strong positive correlations (R 2 = 0.9943) were observed between the ascorbic acid content and

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“…Tamarillo fruits are rich in vitamins C and E as well as in provitamin A (McCane and Widdowson 1992). High levels of potassium and iron (McCane and Widdowson 1992), anthocyanins (Hurtado et al 2009) and other phenolics showing antioxidant properties have also been found (Kou et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Ploidy stability in embryogenic cultures and regenerated plantlets of tamarillo

Currais

Loureiro

Santos

et al. 2013

Plant Cell Tiss Organ Cult

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Ploidy levels of short-term (1 and 2 years) and long-term (7 and 10 years) embryogenic cultures as well as of regenerated plantlets of tamarillo were analyzed by flow cytometry and chromosome counts. Embryogenic cultures were induced from expanding leaves cultured in the presence of Picloram or 2,4-dichlorophenoxyacetic acid (2,4-D) and monthly subcultured on the same media. Embryo development and plantlets were obtained following subculture of the embryogenic tissue in auxin free medium containing gibberellic acid (GA 3). Seedlings and rooted shoots from axillary shoot proliferation were used as controls. The results showed that in long-term embryogenic cultures the ability to develop somatic embryos and plantlets was reduced. Embryogenic tissues maintained for 10 years were mostly aneuploids of the tetraploid (2n = 4x = 48) level whereas those kept in culture for 7 years or less were also mostly aneuploids but of the diploid (2n = 2x = 24) level. The results obtained by flow cytometry were, in general, consistent with those obtained by chromosome counts. The chromosome alteration observed in the embryogenic tissues was already present after 1 year of culture and increased with culture age, hence impairing the maintenance of these tissues for long periods without affecting chromosome stability of the regenerated plantlets. However, the occurrence of triploids and tetraploids as well as aneuploids can be useful for breeding purposes. A value around 23 pg/2C was found for the genome size of tamarillo largely exceeding the value previously published (15.50 pg/2C).

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Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress

Cited by 44 publications

References 25 publications

Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

Nutritional Compositions and Antiproliferative Activities of Different Solvent Fractions from Ethanol Extract of Cyphomandra betacea (Tamarillo) Fruit

A Comparative Study of the Antioxidant Properties of Three Pineapple (Ananas comosus L.) Varieties

Ploidy stability in embryogenic cultures and regenerated plantlets of tamarillo

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