2004
DOI: 10.1016/j.clpt.2004.03.002
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Abstract: The allelic and genotypic frequencies of CYP2C9*1, *2, and *3 in white and black Brazilians are similar to those reported for other white (Caucasian) and black (African and African American) populations, respectively. Heterozygosis for CYP2C9*3, and to a lesser degree CYP2C9*2, increases the exposure to tenoxicam during single and repeated doses.

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Cited by 83 publications
(63 citation statements)
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“…In accordance, Asiatics and Africans 1 also had shown a low incidence of both CYP2C9*2 (4%) and CYP2C9*3 (2%) alleles. Similarly, black North 10 and South Americans 22,23 showed low mutation rates of CYP2C9*2 and CYP2C9*3 alleles, 1.0-4.5 and 0.5-3.2 respectively. The frequencies of the CYP2C9*2 (9%) and CYP2C9*3 (7%) found in our epileptic Brazilian population were very close to those found in European populations (Figure).…”
Section: Resultsmentioning
confidence: 99%
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“…In accordance, Asiatics and Africans 1 also had shown a low incidence of both CYP2C9*2 (4%) and CYP2C9*3 (2%) alleles. Similarly, black North 10 and South Americans 22,23 showed low mutation rates of CYP2C9*2 and CYP2C9*3 alleles, 1.0-4.5 and 0.5-3.2 respectively. The frequencies of the CYP2C9*2 (9%) and CYP2C9*3 (7%) found in our epileptic Brazilian population were very close to those found in European populations (Figure).…”
Section: Resultsmentioning
confidence: 99%
“…Brazil represents one of World's most heterogeneous populations, as the result of 500 years of extensive interethnic crossover. Until now, just three studies assessed the CYP2C9 polymorphism frequency among Brazilian population [22][23][24] . The genotype analyses revealed that the frequencies of CYP2C9*2 and CYP2C9*3 were 8-9% and 6-7% 22,23 .…”
mentioning
confidence: 99%
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“…[11][12][13][14][15][16][17][18][19][20][21][22][23] Here we present a descriptive study of the prevalence of the most relevant CYP2C9 polymorphisms, CYP2C9*1 (wild type), CYP2C9*2 and CYP2C9*3, in population samples from both Spain (Basque Country, Catalonia, Central Spain and Galicia) and northern Italy (Verona) summing up a total of 1240 individuals. We also compared the allele frequencies on our population samples with those previously published for other European populations.…”
Section: Introductionmentioning
confidence: 99%
“…58 The in vivo clearance of tenoxicam for the CYP2C9 Ile359 to Leu359 variant allele represents o10% of that of the wild-type allele. 59 Vianna-Jorge et al 58 studied the frequency of CYP2C9*1, CYP2C9*2 and CYP2C9*3 among Brazilians and their influence on the pharmacokinetics of tenoxicam (20 mg). They reported a similar frequency of the examined alleles in Brazilian population compared with that of Caucasians.…”
Section: Piroxicammentioning
confidence: 99%