Cynara scolymus leaves extract alleviates nandrolone decanoate-induced alterations in testicular function and sperm quality in albino rats

Mohammed, Eman; Radi, Abeer M.; Aleya, Lotfi; Abdel-Daim, Mohamed M.

doi:10.1007/s11356-019-07302-4

Cited by 18 publications

(11 citation statements)

References 61 publications

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“…They also cause biochemical modifications of prostatic secretion and seminal liquid. Most of these degenerative changes are partially reversible after treatment suspension [ 33 , 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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Background and Objectives: Androgens play a significant role in the development of male reproductive organs. The clinical use of synthetic testosterone derivatives, such as nandrolone, is focused on maximizing the anabolic effects and minimizing the androgenic ones. Class II anabolic androgenic steroids (AAS), including nandrolone, are rapidly becoming a widespread group of drugs used both clinically and illicitly. The illicit use of AAS is diffused among adolescent and bodybuilders because of their anabolic proprieties and their capacity to increase tolerance to exercise. This systematic review aims to focus on side effects related to illicit AAS abuse, evaluating the scientific literature in order to underline the most frequent side effects on AAS abusers’ bodies. Materials and Methods: A systematic review of the scientific literature was performed using the PubMed database and the keywords “nandrolone decanoate”. The inclusion criteria for articles or abstracts were English language and the presence of the following words: “abuse” or “adverse effects”. After applying the exclusion and inclusion criteria, from a total of 766 articles, only 148 were considered eligible for the study. Results: The most reported adverse effects (found in more than 5% of the studies) were endocrine effects (18 studies, 42%), such as virilization, gynecomastia, hormonal disorders, dyslipidemia, genital alterations, and infertility; cardiovascular dysfunctions (six studies, 14%) such as vascular damage, coagulation disorders, and arteriosus hypertension; skin disorders (five studies, 12%) such as pricking, acne, and skin spots; psychiatric and mood disorders (four studies, 9%) such as aggressiveness, sleep disorders and anxiety; musculoskeletal disorders (two studies, 5%), excretory disorders (two studies, 5%), and gastrointestinal disorders (two studies, 5%). Conclusions: Based on the result of our study, the most common adverse effects secondary to the abuse of nandrolone decanoate (ND) involve the endocrine, cardiovascular, skin, and psychiatric systems. These data could prove useful to healthcare professionals in both sports and clinical settings.

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Section: Discussionmentioning

confidence: 99%

Nandrolone Decanoate: Use, Abuse and Side Effects

et al. 2020

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“…Furthermore, C. cardunculus L. extracts possess antimicrobial [125][126][127], antioxidant [125,127,128], and anti-inflammatory [127,129] properties, as extensively described in the literature. The possible mechanism supporting the biological activity of C. cardunculus might be due to its content of vitamins, flavonoids, and polyphenols, since they are potent free-radical scavengers that prevent oxidative stress, which is intrinsically connected to the hepatoprotective, hypolipidemic, and antidiabetic activity [130,131].…”

Section: Cynara Cardunculus and Its Effect On Metabolic Disordersmentioning

confidence: 99%

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Silva

Jacinto

Coutinho

2022

Foods

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Cardoon (Cynara cardunculus L.) is a Mediterranean plant and member of the Asteraceae family that includes three botanical taxa, the wild perennial cardoon (C. cardunculus L. var. sylvestris (Lamk) Fiori), globe artichoke (C. cardunculus L. var. scolymus L. Fiori), and domesticated cardoon (C. cardunculus L. var. altilis DC.). Cardoon has been widely used in the Mediterranean diet and folk medicine since ancient times. Today, cardoon is recognized as a plant with great industrial potential and is considered as a functional food, with important nutritional value, being an interesting source of bioactive compounds, such as phenolics, minerals, inulin, fiber, and sesquiterpene lactones. These bioactive compounds have been vastly described in the literature, exhibiting a wide range of beneficial effects, such as antimicrobial, anti-inflammatory, anticancer, antioxidant, lipid-lowering, cytotoxic, antidiabetic, antihemorrhoidal, cardiotonic, and choleretic activity. In this review, an overview of the cardoon nutritional and phytochemical composition, as well as its biological potential, is provided, highlighting the main therapeutic effects of the different parts of the cardoon plant on metabolic disorders, specifically associated with hepatoprotective, hypolipidemic, and antidiabetic activity.

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“…In addition, liver tissue is well studied to be the primary site of nicotine biotransformation where it exerts a number of adverse physiological effects on the liver. After nicotine is absorbed through the lungs during smoking, it is rapidly metabolized in the liver promoting three main undesirable Responsible Editor: Mohamed M. Abdel-Daim effects on the liver: toxic effects (direct or indirect), immunomodulatory effects, and carcinogenic effects (Hukkanen et al 2005;El-Zayadi 2006;Mohammed and Safwat 2013;Mohammed et al 2020). Moreover, smoking causes genotoxic effects and cell injury in rat livers.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, nanoparticles have been used for many medical purposes rather than the same bulky materials because nanoparticles have unique physical and chemical properties and also exhibit different activities, due to limited electronic properties (Hochella 2002 ; Lead and Wilkinson 2006 ; Madden et al 2006 ; Mohammed and Safwat 2013 ; Mohammed et al 2020 ). Nanomaterials exhibited many biological effects with their potential advantages (Rudramurthy et al 2016 ; Abdel-Daim et al 2019 ; El-Sayed and Kamel 2020a , b ; El-Sayed and Kamel 2020a ; Bhattacharya et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Alleviation of nicotine-induced reproductive disorder, clastogenicity, and histopathological alterations by fenugreek saponin bulk and nanoparticles in male rats

Hamed

El-Fiky

Gawish

et al. 2022

Environ Sci Pollut Res

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Nicotine is the most abundant ingredient in cigarette smoking and has serious side effects on the lung, heart, reproductive system, and many other human organs. Saponins extracted from many plants exhibit multiple biological actions such as anti-cancer effects. Therefore, the possible protective effect of fenugreek saponin (FS) and nanofenugreek saponin (NFS) against nicotine-induced toxicity in male rats was investigated in this study. Animals were divided into a control group and the nicotine (1.5 mg/kg/day), FS (25, 50, and 100 mg/kg/day), or/and NFS (20, 40, and 80 mg/kg/day) administered groups. Micronucleus assay, histopathological, and sperm abnormality examinations as well as measurement of the acetylcholinesterase (AChE) gene expression were conducted. Our findings revealed that nicotine treatment induced significant increases in the incidence of micronucleus, sperm abnormalities, and expression levels of AChE in addition to inducing histopathological changes in rat testis. On the other hand, administration of FS or NFS with nicotine significantly decreased the incidence of micronuclei and the percentage of sperm abnormalities as well as the expression levels of AChE gene. Moreover, nicotine-induced histological alterations were reduced by given FS or NFS with nicotine. In conclusion, nicotine-induced sperm abnormalities, chromosomal damage, and histological injuries were mitigated by administration of FS or NFS with nicotine, and thus, FS and NFS could be used as ameliorating agents against nicotine toxicity. Graphical abstract

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Cynara scolymus leaves extract alleviates nandrolone decanoate-induced alterations in testicular function and sperm quality in albino rats

Cited by 18 publications

References 61 publications

Nandrolone Decanoate: Use, Abuse and Side Effects

Nandrolone Decanoate: Use, Abuse and Side Effects

Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders

Alleviation of nicotine-induced reproductive disorder, clastogenicity, and histopathological alterations by fenugreek saponin bulk and nanoparticles in male rats

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