Cylindroma and eccrine spiradenoma coexistent in the same lesion

Malignant eccrine spiradenoma: a new case report

“…In addition, other histologic features and patterns may be observed, such as squamous morules, clear cell and oncocyte-like cytoplasm, sarcomatoid change and malignant mixed tumor like areas. 7,12 The presence of areas of cylindromatous changes is also noted in several lesions of ES, indicating the coexistence of both tumors in the same lesion as previously reported by Goette et al 13 These findings provide circumstantial evidence that both tumors are derived from a common pluripotential basal cell line. 9 However, Spiradenoma and cylindroma appear to be related to the folliculo-sebaceous apocrine unit, possessing elements similar to both embryologic and differentiated aspects of this unit.…”

Trichoepitheliomas and eccrine spiradenomas with spiradenoma/cylindroma overlap

“…Occasionally, spiradenomas may exhibit cylindromatous features or mixed differentiation with foci of cylindroma present within the tumor, as in the case reported here. [5][6][7] Rare malignant transformation has been reported, usually in the setting of a previously benign eccrine spiradenoma. 8 Symptoms that should cause concern for possible malignancy of a pre-existing nodule include rapid increase in size, worsening pain, color change, or ulceration.…”

“…11 Therefore, the coexistence of trichoepitheliomas and cylindromas implies that cylindromas may be of apocrine origin. 14 However, the repeated occurrence of eccrine spiradenomas in patients with BSS and their coexistence in the same lesion with cylindromas, 6,7 "spiradenocylindroma", 6 has called into question the eccrine origin of cylindromas.…”

Brooke–Spiegler Syndrome: Treatment of Cylindromas with CO2 Laser

“…19 The similarity of the morphology of cylindroma and spiradenoma, reinforced by the presence of the two tumors in the same lesion, as it happens in patient 2, and the existence of transitional forms, corroborate this theory. [20][21][22] Their combination with tricoepithelioma in the Brooke-Spiegler syndrome might also support the hypothesis of development from pluripotential basal cells.…”