Cyclosporine. An immunosuppressant affecting epithelial cell proliferation

Possible Antipruritic Mechanism of Cyclosporine A in Atopic Dermatitis

“…S1 1 ). These findings were also supported by a previous report that non-immunosuppressive CsA is useful in the treatment of hyperproliferative epidermal diseases (40).…”

“…These results suggest that CsA affects not only sensory nerve fibres in the epidermis, but also immune cells and other cells, such as keratinocytes. We also found that CsA dose-dependently normalized acanthosis, possibly by homeostasis and integrity regulation of epidermal keratinocytes (40,41,43). In fact, 5 mg/kg CsA was effective for promoting the integrity of the skin barrier in this study (Fig.…”

“…Previous studies have shown that Th2 cytokines, including IL-4 and IL-13, were also inhibited by CsA treatment (38,39). Some studies indicated that CsA also inhibits cell proliferation, migration, and invasion (40)(41)(42). These results suggest that CsA affects not only sensory nerve fibres in the epidermis, but also immune cells and other cells, such as keratinocytes.…”

Mitotic Activity of Keratinocytes in Nifedipine‐ and Immunosuppressive Medication‐Induced Gingival Overgrowth

“…15 The thickening of gingival epithelium in CsA-induced gingival overgrowth, 7 and hypertrichosis 11 as a side effect of human in vivo CsA therapy, and the lack of an effect by CsA on lamellar ichthyosis 16 heavily influenced by culture conditions; e.g., CsA concentrations used. 10 An association between CsA-and nifedipine-induced gingival overgrowth and clinical inflammation has been recorded in several papers. 1,13 Odile et al 13 showed that the mean proliferation rate in epithelial cell cultures derived from the clinically non-to-slightly inflamed gingiva was significantly higher than rates in those derived from the moderately and severely inflamed gingiva.…”

Effects of Hypertrichotic Agents on Follicular and Nonfollicular Cells in vitro

“…This potent hypertrichotic agent not only causes a suppressive effect on T lymphocytic cells but also on epithelial cells [1]. This pharmacody namic discrepancy between the clinical hyper trichotic side effect and the suppressive na ture of cultured follicular cells suggests that cyclosporin has a different mechanism from that of minoxidil.…”