Cyclosporin Treatment of Atopic Dermatitis: Is It Really Associated with Infectious Diseases?

Kim, Shin‐Woo; Park, Young Woon; Kwon, In Ho; Kim, Kyu Han

doi:10.5021/ad.2010.22.2.170

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…Surprisingly, the incidence of infections tended to be lower in the ciclosporin group. Eczema herpeticatum as the most frequent infectious disease was not increased in the ciclosporin group [33].…”

Section: 12 Ciclosporinmentioning

confidence: 99%

Update “Systemic treatment of atopic dermatitis” of the S2k‐guideline on atopic dermatitis

Werfel

Heratizadeh

Aberer

et al. 2021

J Deutsche Derma Gesell

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Summary This guideline is an update from August 2020 the S2k‐guideline “Atopic dermatitis” published in 2015. The reason for updating this chapter of the guideline were the current developments in the field of systemic therapy of atopic dermatitis. The agreed recommendations for systemic treatment in atopic dermatitis of the present guideline are based on current scientific data. Due to the approval of dupilumab for the treatment of moderate to severe atopic dermatitis, which cannot be treated sufficiently with topical drugs alone, this part of the guideline has now been adapted and newly consented. The indication for systemic therapy and the therapeutic response to topical and systemic treatment should be recorded and documented in a suitable form in clinic and practice. A standardized documentation of the indication for system therapy in atopic dermatitis can be recommended and is also part of the updated chapter of this guideline.

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Section: 12 Ciclosporinmentioning

confidence: 99%

Update “Systemic treatment of atopic dermatitis” of the S2k‐guideline on atopic dermatitis

Werfel

Heratizadeh

Aberer

et al. 2021

J Deutsche Derma Gesell

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show abstract

“…Although topical tacrolimus is not associated with an increased risk of infections [ 95 ], there have been reports of herpes simplex infection, MC [ 96 ], and extensive varicella zoster infection [ 97 ] so caution should be exercised with its use. Interestingly however, the use of systemic immunosuppressives such as ciclosporin has not been associated with an increased risk of infections in a cohort of Korean AD patients [ 98 ]. Suppressing the Th2 infl ammatory response in AD with corticosteroids [ 99 ] and calcineurin inhibitors is the cornerstone in AD treatment, and theoretically this may decrease the Th2 cytokine milieu-mediated suppression of fi laggrin synthesis and reduce the allergic infl ammation triggered by S. aureus , thereby concomitantly improving the dysfunctional barrier and decreasing bacteria-induced damage.…”

Section: Discussionmentioning

confidence: 92%

Filaggrin and Skin Infections

2014

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“…Short-term randomized controlled trials showed that even moderate amounts of fructose consumption impaired glucose and lipid metabolism [9] and decreased insulin sensitivity [10], playing a crucial role in the development of metabolic disorders, contributing to atherosclerosis, thus resulting in a higher risk of CHD. Another detrimental effect of fructose reported by epidemiological and intervention study is the increase of uric acid level in serum, which is a risk factor for CHD [11][12].…”

Section: Review:-1-cardiovascular Systemmentioning

confidence: 99%