Cyclooxygenase‐2 inhibitory and antioxidant compounds from the truffle <i>Elaphomyces granulatus</i>

Stanikunaite, Rita; Khan, Shabana I.; Trappe, James M.; Ross, Samir A.

doi:10.1002/ptr.2698

Cited by 80 publications

(53 citation statements)

References 14 publications

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“…Cyclooxygenase are enzymes involved in the process of inflammation (Noreen, Ringbom, Perera, Danielson, & Bohlin, 1998). They catalyse the rate-limiting step in the biosynthesis of prostaglandins, prostacyclins, and thromboxanes from arachidonic acid (Zhang, Mills, & Nair, 2003;Diyabalanage, Mulabagal, Mills, DeWitt, & Nair, 2008;Stanikunaite, Khan, Trappe, & Ross, 2009;Han, Oh, & Park, 2011;Fangkrathok, Junlatat, & Sripanidkulchai, 2013).…”

Section: Nsaids and Their Mechanism Of Actionmentioning

confidence: 99%

“…This is not a very common method for anti-inflammatory activity assessment, but it has been reported in some publications (Noreen, Ringbom, Perera, Danielson, & Bohlin, 1998;Zhang et al, 2003;Yoshikawa et al, 2005;Stanikunaite, Khan, Trappe, & Ross, 2009 …”

Section: Cox-1 and Cox-2 Catalyzed Prostaglandin Biosynthesis Assaymentioning

confidence: 99%

“…polysaccharides (Dore, et al, 2007;Lu, et al, 2008;Lavi, Levinson, Peri, Hadar, & Schwartz, 2010;Adebayo, Oloke, Majolagbe, Ajani, & Bora, 2012;Ruthes, et al, 2013aRuthes, et al, , 2013bRuthes, et al, , 2013cChang, Lur, Lu, & Cheng, 2013;Castro et al, 2014;Silveira et al, 2014;Silveira et al, 2015), terpenes (Kamo, Asanoma, Shibata, & Hirota, 2003;Yoshikawa et al, 2005;Dudhgaonkar, Thyagarajan, & Sliva, 2009;Ma, Chen, Dong, & Lu, 2013;Tung et al, 2013;Xu, Yan, Bi, Han, Chen, & Wu, 2013;Choi, et al, 2014a), phenolic compounds (Quang, Harinantenaina, Nishizawa, Hashimoto, Kohchi, Soma, & Asakawa, 2006a;Quang et al, 2006bKohno et al, 2008Stanikunaite, Khan, Trappe, & Ross, 2009;Hsieh et al, 2010;Lee, & Huang et al, 2011b;Chen et al, 2013;Taofiq et al, 2015), sterols (Huang, et al, 2010;Ma, Chen, Dong, & Lu, 2013 anti-inflammatory activity of extracts prepared from mushrooms after undergoing some food processing procedures. The results showed reduced activity compared to fresh samples, which implies that anti-inflammatory compounds present in these mushrooms were degraded, e.g due to suseptibility to heating.…”

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

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Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

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Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach:The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action.Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions:The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites.Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.

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Section: Nsaids and Their Mechanism Of Actionmentioning

confidence: 99%

Section: Cox-1 and Cox-2 Catalyzed Prostaglandin Biosynthesis Assaymentioning

confidence: 99%

Section: The Anti-inflammatory Potential Of Mushroom Extractsmentioning

confidence: 99%

See 1 more Smart Citation

Anti-inflammatory potential of mushroom extracts and isolated metabolites

Taofiq

Martins

Barreiro

et al. 2016

Trends in Food Science & Technology

105

View full text Add to dashboard Cite

show abstract

“…They are reported to exert inhibitory effects on cyclooxygenase-2 (COX-2) (Deng et al, 2000) and prostaglandin synthase (Stanikunaite et al, 2009) as well as ethyl phenylpropionateinduced edema of the rat ear (Farah & Samuelsson, 1992). Their antioxidant activity has equally been reported (Farah & Samuelsson, 1992).…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory and antinociceptive activities ofHomalium letestui

Okokon¹,

Okokon²,

Farooq³

et al. 2013

Pharmaceutical Biology

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Context: Homalium letestui Pellegr (Flacourtiaceae) is used in various decoctions traditionally by the Ibibios of the Niger Delta of Nigeria to treat stomach ulcer, malaria and other inflammatory diseases, as well as an aphrodisiac. Objective: To investigate the anti-inflammatory and antinociceptive activities of the stem extract of the plant. Materials and methods: The ethanol stem extract (500, 750, 1000 mg/kg, i.p.) of H. letestui was investigated for anti-inflammatory activity using carrageenan, egg albumin-induced and xylene-induced ear edema models and analgesic activity using acetic acid-induced writhing, formalin-induced paw licking and thermal-induced pain models. The ethanol extract was administered to the animals orally, 30 min to 1 h depending on the model, before induction of inflammation/pain. The LD 50 was also determined. GC-MS analysis of dichloromethane fraction was carried out. Results: The extract caused a significant (p50.05-0.001) reduction of inflammation induced by carrageenan (8.3-70.0%), egg albumin (10.0-71.42%) and xylene (39.39-84.84%). The extract also reduced significantly (p50.05-0.001) pain induced by acetic acid (44.22-73.65%), formalin (55.89-79.21%) and hot plate (93.0-214.5%). The LD 50 was determined to be 4.38 AE 35.72 g/kg. Discussion and conclusion: The results of this study suggest that the ethanol stem extract of H. letestui possesses anti-inflammatory and analgesic properties which may in part be mediated through the chemical constituents of the plant as revealed by the GC-MS.

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“…Anti-inflammatory and antioxidant properties have been described for dihydrocoumarin, reported to be one of the major compounds in hydroalcoholic extracts. Syringaldehyde has been shown to have a moderate antioxidant activity (Bortolomeazzi et al, 2007) and a dose-dependent inhibition of cyclooxygenase-2 (COX-2) activity (IC 50 = 3.5 μg/mL), thereby contributing to the anti-inflammatory properties of guaco extracts (Farah & Samuelsson, 1992;Stanikunaite et al, 2009). Kaurenoic acid (ent-kaur-16-en-19-oic acid) has lately been of considerable interest relating to the pharmacological activities of guaco species.…”

Section: Mikania Glomerata and M Laevigata: Clinical And Toxicologicmentioning

confidence: 99%