Cyclodextrins inclusion complex: Preparation methods, analytical techniques and food industry applications

Advances in Nanostructures for Antimicrobial Therapy

“…Several colloidal delivery systems such as micro- and nanoemulsions [ 52 ], liposomes [ 53 , 54 , 55 ], solid lipid nanoparticles (SLNPs) [ 56 , 57 ], nanostructured lipid carriers (NLCs) [ 58 , 59 , 60 ], liquid crystalline NPs [ 61 ], biopolymer microgels [ 62 ], nanocapsules [ 63 ], cyclodextrins (CDs) [ 64 , 65 , 66 , 67 ], smart responsive materials polymer-based NPs [ 68 , 69 , 70 , 71 ] or dendrimers [ 72 , 73 ] can be used for encapsulation of pharmacologically active compounds. By internalization of drugs to nanocarriers (NCs) their stability, bioavailability, cellular uptake/internalization, and pharmacokinetic profile can be ameliorated along with the reduction of their toxicity [ 42 , 74 , 75 , 76 ].…”

“…These inorganic carriers are usually functionalized with the above-mentioned organic polymers, resulting in hybrid NCs, in which active molecules are trapped. Depending on the used material, different NCs are formed, such as liposomes/lipid-based delivery systems, polymeric NPs (micelles, spheres, capsules), dendrimers, polymeric complex NPs, CDs, nanocrystals, electrospun nanofibers, electro-sprayed NPs, nano-spray dried particles, covalent organic frameworks, hydrogels, inorganic nanosystems (quantum dots, carbon based NPs) [ 41 , 45 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 117 , 118 , 119 , 120 , 125 , 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 , 143 ]. Table 1 provides an overview of the types of nanoformulations discussed and their basic building blocks, while Figure 2 , Figure 3 , Figure 4 and Figure 5 illustrate the individual anti-infective drugs listed in this review.…”

“…Cyclodextrin (CD) [ 64 , 65 , 66 , 67 ] inclusion complexes, CD coupling, supramolecular hydrogels, and supramolecular micelles are the most frequently used CD-based controlled release systems [ 176 ]. By hydrophobic inclusion of oleylamine in β-CD, a supramolecular amphiphile was prepared, forming a self-assembled nanovesicles showing a size of 125.1 ± 8.30 nm and zeta potential of 19.3 ± 9.20 mV exhibiting sustained release of encapsulated VAN during 48 h and showing 2- and 4-fold lower minimum inhibitory concentrations (MICs) against S. aureus and MRSA as well as 459-fold reduction of intracellular bacteria using infected human embryotic kidney cells (HEK), and an 8-fold reduction in infected macrophages compared to bare drug [ 177 ].…”

Antimicrobial Properties of Chilean Native Plants: Future Aspects in Their Application in the Food Industry

“…Extracts containing bioactive molecules can sometimes degrade with temperature, oxidize, or change the food’s smell and/or taste inside the packaging. Adding oligosaccharides, such as cyclodextrins, can improve the effectiveness of the active plant molecules in the films [ 107 ]. For example, a starch-based active packaging with antimicrobial properties can be made by adding an Acca sellowiana (Feijoa) by-product [ 108 ].…”

Novel Chloro-Substituted Salicylanilide Derivatives and Their β-Cyclodextrin Complexes: Synthesis, Characterization, and Antibacterial Activity

“…Complex formation is based on hydrophobic forces and the size of guest molecules and their properties, elements that are responsible for the complexes’ stability. The process of partial or total encapsulation of a guest molecule occurs when a hydrophobic molecule or just a hydrophobic fragment of a polar molecule is integrated in the cyclodextrin (CD) cavity, causing a shift of water molecules from the cavity and as a result increasing the aqueous solubility of the sample [ 16 ].…”