Cyclodextrin/PEG based hydrogels for multi-drug delivery

Salmaso, Stefano; Semenzato, Alessandra; Bersani, Sara; Matricardi, Pietro; Rossi, Fabio; Caliceti, Paolo

doi:10.1016/j.ijpharm.2007.05.035

Cited by 101 publications

(61 citation statements)

References 31 publications

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“…Due to the high water content and large pore sizes of most hydrogels, a relative rapid drug release over a few hours to a few days may occur (13). Several well-known chemically cross-linked hydrogels may be obtained using homopolymers or copolymers, and grafted, branched or linear polymers (28). Cyclodextrins (cyclic oligosaccharides, CDs) have been proposed as a new attractive biomaterial (29)(30)(31)) to obtain hydrogels, combining both, the favorable property of CDs to form inclusion complexes and the swelling behavior of hydrogels.…”

Section: The Use Of Cyclodextrins As a Strategy To Improve The Designmentioning

confidence: 99%

“…Salmaso et al reported that CDbased hydrogel can be a properly controlled and sustained drug delivery system. High cross linked polymer networks made with acrylic or vinyl monomers of CDs are particularly promising materials for controlled delivery systems for the administration of lipophilic drugs (28).…”

Section: The Use Of Cyclodextrins As a Strategy To Improve The Designmentioning

confidence: 99%

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Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Ribeiro¹,

Figueiras²,

Veiga³

2015

J Pharm Pharm Sci

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-Purpose. Conventional ophthalmic systems present very low corneal systemic bioavailability due to the nasolacrimal drainage and the difficulty to deliver the drug in the posterior segment of ocular tissue. For these reasons, recent advances have focused on the development of new ophthalmic drug delivery systems. This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings in soft contact lenses (SCL) and the applications of novel pharmaceutical systems for ocular drug delivery. Among the new therapeutic approaches in ophthalmology, SCL are novel continuous-delivery systems, providing high and sustained levels of drugs to the cornea. The tendency of research in ophthalmic drug delivery systems development are directed towards a combination of several technologies (bio-inspired and molecular imprinting techniques) and materials (cyclodextrins, surfactants, specific monomers). There is a tendency to develop systems which not only prolong the contact time of the vehicle at the ocular surface, but also at the same time slow down the clearance of the drug. Different materials can be applied during the development of contact lenses and can be combined with natural inspired strategies of drug immobilization and release, providing successful tools for ocular drug delivery systems.

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Section: The Use Of Cyclodextrins As a Strategy To Improve The Designmentioning

confidence: 99%

Section: The Use Of Cyclodextrins As a Strategy To Improve The Designmentioning

confidence: 99%

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Ribeiro¹,

Figueiras²,

Veiga³

2015

J Pharm Pharm Sci

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“…Hydrogel-amphiphile systems have been developed and characterized due to potential applications within controlled drug release [16][17][18], pollutants removal [19][20][21], enhanced oil recovery [22], or microheterogeneous catalysis [23,24]. Ionic hydrogels shows adsorption properties towards oppositely charged amphiphiles.…”

Section: Introductionmentioning

confidence: 99%

High resolution interferometry as a tool for characterization of swelling of weakly charged hydrogels subjected to amphiphile and cyclodextrin exposure

Gao

Gawel

Stokke

2013

Journal of Colloid and Interface Science

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A high resolution interferometric technique was used to determine swelling behavior of weakly charged polyacrylamide hydrogels in the presence of oppositely charged surfactants and subsequent exposure to cyclodextrins. Hydrogels of copolymerized acrylamide and 2-acrylamido-2-methyl-1-propanesulfonic acid (0.22, 0.44, 0.88 mol%) and crosslinked with bisacrylamide (3, 6, 12 mol%) were employed. The equilibrium swelling and swelling kinetics of the hydrogels were determined with 2 nanometer resolution of the optical length and sampled at approximately 1 Hz. These properties were determined for the hydrogels exposed to cationic surfactants dodecyltrimethylammonium bromide (DTAB) and cetyltrimethylammonium bromide (CTAB) at concentrations from 10

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“…Between the multitude of substances included in cyclodextrins or in their polymeric gels, mention should be made of: drugs, [2][3][4] water pollutants such as b-naphthol, 5 phenolic derivatives, 6 aromatic compounds, 7,8 various dyes, [9][10][11][12] all providing a versatile method for the protection of the environment by waste water treatment. 13 Other CyD-based hydrogels were synthesized and tested for multidrug delivery 14 or/and controlled release systems. 15 The CyD hydrogels contain either polysaccharides [11][12][13] comonomers, which can improve their absorption performances through increasing the network hydrophilicity, or acrylic comonomers, which provide environmental stimuli response of the network during loading or release of the drug.…”

Section: Introductionmentioning

confidence: 99%

Cyclodextrin‐anionic polysaccharide hydrogels: Synthesis, characterization, and interaction with some organic molecules (water pollutants, drugs, proteins)

Mocanu¹,

Mihai²,

Lecerf³

et al. 2009

J of Applied Polymer Sci

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Hydrogel microparticles have been prepared through cocrosslinking of cyclodextrin and of anionic carboxymethyl or sulfopropyl pullulan with a new bifunctional reagent: 3-(glycidoxypropyl)trimethoxysilane. This reagent forms crosslinking both through grafting with the epoxy end on the OH polysaccharide and through hydrolysis and condensation of the methoxy silane groups from the other end. Samples of cyclodextrin/anionic polysaccharides with various amounts of crosslinking agent were prepared. Characterization of the hydrogel microparticles considered the water swelling behavior, porosity measurements, retention of biologically active substances, which can occur by their inclusion in cyclodextrin inner cavities and in the pores of hydrogels, as well as through the electrostatic forces toward anionic polyelectrolyte charges. Their improved retention of various organic molecules as water pollutants, drugs, enzymes, recommend them as chromatographic supports, supports for the separation/immobilization of enzymes or for controlled release systems.

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Cyclodextrin/PEG based hydrogels for multi-drug delivery

Cited by 101 publications

References 31 publications

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

Improvements in Topical Ocular Drug Delivery Systems: Hydrogels and Contact Lenses

High resolution interferometry as a tool for characterization of swelling of weakly charged hydrogels subjected to amphiphile and cyclodextrin exposure

Cyclodextrin‐anionic polysaccharide hydrogels: Synthesis, characterization, and interaction with some organic molecules (water pollutants, drugs, proteins)

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