Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes

Allahyari, Saeideh; Zahednezhad, Fahimeh; Khatami, Mohamad; Hashemzadeh, Nastaran; Zakeri–Milani, Parvin; Trotta, Francesco

doi:10.1016/j.jddst.2021.102931

Cited by 24 publications

(21 citation statements)

References 80 publications

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“…However, future explorations should be focused on important aspects of up-scale production, optimization of synthesis conditions, and clinical transformation. 124 Cyclodextrin-centered nanosponges have been applied for the delivery of flavonoid drugs (e.g., quercitrin) with improvement in solubility and enhanced anticancer activities. 125 In one study, β-cyclodextrin and 2-hydroxy propyl-β-cyclodextrin crosslinked with diphenyl carbonate were deployed for loading quercitrin.…”

Section: Advanced Nanosystems For Targeted Cancer Therapeuticsmentioning

confidence: 99%

Advanced Nanosystems for Cancer Therapeutics: A Review

Mohajer

Mirhosseini‐Eshkevari

Ahmadi

et al. 2023

ACS Appl. Nano Mater.

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Since cancer has a very complex pathophysiology, existing cancer treatment strategies encounter several challenges such as the lack of specificity/selectivity, induction of multidrug resistance, and possible side effects/toxicity. A wide variety of organic, inorganic, and hybrid nanosystems have been designed with unique magnetic, thermal, mechanical, electrical, and optical properties for targeted cancer therapy. These advanced nanosystems with enhanced bioavailability, biocompatibility, and drug loading capacity have been developed for targeted cancer therapy to reduce toxicity and improve the targeting properties. In this context, challenges persist for their clinical translational studies and enhancement of their therapeutic efficiency as well as the optimization of synthesis conditions and large-scale production. In addition, despite promising preclinical results, the number of nanosystems available to patients is still very low, partly due to a lack of understanding of the differences among animal model species and humans that influence the behavior and functionality of these nanosystems. Regarding this, organ-on-a-chip platforms can significantly help in drug screening and delivery aspects in cancer/tumor cells as well as cancer modeling research; the organs-on-chip approach can also be helpful to analyze the cancer–immune cells interactions. Future studies should focus on the exploration of multifunctional nanosystems with synergistic chemo-photothermal, photothermal/photodynamic, and cancer immunotherapeutic potentials as well as smart nanosystems with theranostic capabilities. Herein, recent advancements pertaining to the applications of advanced nanosystems for cancer therapeutics are deliberated. Current obstacles and limitations hindering the application from research to clinical uses are also discussed while providing recommendations for a more efficient adoption of nanomaterials in the treatment of cancers.

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Section: Advanced Nanosystems For Targeted Cancer Therapeuticsmentioning

confidence: 99%

Advanced Nanosystems for Cancer Therapeutics: A Review

Mohajer

Mirhosseini‐Eshkevari

Ahmadi

et al. 2023

ACS Appl. Nano Mater.

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“…Furthermore, CDNSs combine high biocompatibility, biodegradability and low cytotoxicity, conferred by the cyclodextrins, with high thermal stability and insolubility that arises from the fact that they are highly crosslinked polymers ( Tejashri et al, 2013 ; Shende P. et al, 2015 ; Krabicová et al, 2020 ; Deng et al, 2021 ; Mashaqbeh et al, 2021 ). Thus, it is not surprising that this type of nanomaterials has been explored for the oral, topical and parenteral delivery of numerous drugs, in controlled drug delivery systems as, for example, for target cancer therapy ( Allahyari et al, 2022 ). It is worth noticing that the same ability and selectivity of CD towards drug encapsulation and delivery can be used for drug scavengers.…”

Section: Applicationsmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges: Overview and Opportunities

et al. 2022

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Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.

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“…Clove essential oil (EO) was successfully encapsulated using ionic gelation into chitosan with tripolyphosphate (TPP) as a crosslinking agent, resulting in a controlled release profile even after 56 days and high encapsulation efficiency, loading capacity and yield, with values of roughly 45.77, 6.18 and 39.05% respectively (Hasheminejad et al ., 2019). Other advanced nanoformulated delivery systems are dendrimers (Yousefi et al ., 2020), nanosponges (Allahyari et al ., 2021), etc. that also have been widely explored for their efficacy to encapsulate essential oils and phytochemicals.…”

Section: Nobel Green Fabrication Technologiesmentioning

confidence: 99%

Use of essential oils and phytochemicals against the mycotoxins producing fungi for shelf‐life enhancement and food preservation

Kumar

Mahato

Gupta

et al. 2022

Int J of Food Sci Tech

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Mycotoxin-producing fungi are a significant source of crop and food contamination, posing a significant threat to global food safety and security. Essential oils, plant extracts and phytochemicals have emerged as green preservatives to extend the shelf-life of foods due to their unique antimicrobial properties. Unlike conventional synthetic preservatives, they are a sustainable and safe way to preserve food with no or little harmful effects on the environment. Use of nanoformulations containing essential oils and phytochemicals offer enormous potential as a mitigation strategy to lower mycotoxin contamination incidences in food and crop with enhanced release behaviour to efficiently transport them to the target location for a rapid reaction without much impact from environmental variables. Hence, this review overviews various essential oils and phytochemicals utilized through nanoformulations to control the mycotoxigenic fungi, probable mechanism of actions involved as well as emerging mycotoxins and associated safety concerns to ensure food sustainability.

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Cyclodextrin nanosponges as potential anticancer drug delivery systems to be introduced into the market, compared with liposomes

Cited by 24 publications

References 80 publications

Advanced Nanosystems for Cancer Therapeutics: A Review

Advanced Nanosystems for Cancer Therapeutics: A Review

Cyclodextrin-Based Nanosponges: Overview and Opportunities

Use of essential oils and phytochemicals against the mycotoxins producing fungi for shelf‐life enhancement and food preservation

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