Cyclodextrin-based nanosponges as promising carriers for active agents

Allahyari, Saeideh; Trotta, Francesco; Valizadeh, Hadi; Jelvehgari, Mitra; Zakeri–Milani, Parvin

doi:10.1080/17425247.2019.1591365

Cited by 55 publications

(34 citation statements)

References 68 publications

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“…In recent decades, synthetic nanoparticles (NPs) including liposomes [ 1 ], micelles [ 2 ], dendrimers [ 3 ], nanocapsules [ 4 ], nanodiamonds [ 5 ], nanosponges [ 6 ], nanoemulsions [ 7 ] and self-assembled peptides [ 8 ] have been extensively studied for nanomedicine, particularly for targeted cancer therapy. Drug delivery systems can improve the pharmacokinetic and pharmacodynamics profiles of therapeutics that carried, thereby enhancing the therapeutic effects while reducing undesired toxicity and side effects [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial exosomes for translational nanomedicine

et al. 2021

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Exosomes are lipid bilayer membrane vesicles and are emerging as competent nanocarriers for drug delivery. The clinical translation of exosomes faces many challenges such as massive production, standard isolation, drug loading, stability and quality control. In recent years, artificial exosomes are emerging based on nanobiotechnology to overcome the limitations of natural exosomes. Major types of artificial exosomes include ‘nanovesicles (NVs)’, ‘exosome-mimetic (EM)’ and ‘hybrid exosomes (HEs)’, which are obtained by top-down, bottom-up and biohybrid strategies, respectively. Artificial exosomes are powerful alternatives to natural exosomes for drug delivery. Here, we outline recent advances in artificial exosomes through nanobiotechnology and discuss their strengths, limitations and future perspectives. The development of artificial exosomes holds great values for translational nanomedicine.

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Section: Introductionmentioning

confidence: 99%

Artificial exosomes for translational nanomedicine

et al. 2021

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“…Cyclodextrin-based nanosponges are nano-scale new drug delivery systems that consist of polymeric structures with various cross-linkers, arranged in a three-dimensional network. These kinds of cyclodextrins can form insoluble porous nanostructures with crystalline/amorphous, spherical shape and also have a swelling trait (Trotta 2011, Trotta et al 2012, Tejashri et al 2013, Allahyari et al 2019. Polymer dimensions and polarisation depend on the amount and type of crosslinker (Trotta et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

Rafati

Zarrabi

Caldera

et al. 2019

Journal of Microencapsulation

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Aim: In this study, a nanosponge structure was synthesised with capability of encapsulating curcumin as a model polyphenolic compound and one of the herbal remedies that have widely been considered due to its ability to treat cancer. Methods: FTIR, DSC and XRD techniques were performed to confirm the formation of the inclusion complex of the nanosponge-drug. Results: DSC and XRD patterns showed an increasing stability and a decreasing crystallinity of curcumin after formation of inclusion complex. Encapsulation efficiency was 98% (w/w) and a significant increase was observed in loading capacity (184% w/w). The results of cytotoxicity assessments demonstrated no cell toxicity on the healthy cell line, while being toxic against cancer cells. Haemolysis test was performed to evaluate the blood-compatibility characteristic of nanosponge and complex and the results showed 0.54% haemolysis in the lowest complex concentration (50μgml −1) and 5.09% at the highest concentration (200μgml −1). Conclusions: Thus, the introduced system could be widely considered in cancer treatment as a drug delivery system.

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“…Fluorescent analysis documented that through targeting process, drug loaded dendrimers could be internalized by breast cancer cells and depressed the development of metastasis in an efficient manner. 29 Other polymers Supramolecular hydrogel as another controllable drug delivery system for hydrophobic drugs 38 was introduced for delivery of BTZ. Sustained release of BTZ from a supramolecular hydrogel in phosphate buffer solution within 12 h experimental period, had been studied by Pu et al This nano-delivery system was composed of three catecholic peptides based on Nap-GFFY that only differ in the number of glutamic acids in their structures.…”

Section: Chitosanmentioning

confidence: 99%

Polymeric Nanoparticles and Their Novel Modifications for Targeted Delivery of Bortezomib

2020

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Bortezomib (BTZ) as a specific proteasome inhibitor is used to inhibit proliferation and migration of tumor cell in variety of cancers. Targeted delivery of this drug not only would minimize its unwanted side effects but also might improve its efficacy. This purpose could be gotten through different pathways but using efficient carriers may be the best one without using any additional ingredients/ materials. Some polymer based nanoparticles with specific functional groups have the ability to interact with boronic acid moiety in BTZ. This reaction might play an important role not only in cancer targeting therapy but also in loading and release properties of this drug. Novel modification such as making multifunctional or pH-sensitive nanocarriers, may also improve anticancer effect of BTZ. This review might have remarkable effect on researchers’ consideration about other possible interactions between BTZ and polymeric nanocarriers that might have great effect on its remedy pathway. It has the ability to brought bright ideas to their minds for novel amendments about other drugs and delivery systems.

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Cyclodextrin-based nanosponges as promising carriers for active agents

Cited by 55 publications

References 68 publications

Artificial exosomes for translational nanomedicine

Artificial exosomes for translational nanomedicine

Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations

Polymeric Nanoparticles and Their Novel Modifications for Targeted Delivery of Bortezomib

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