volume 3, issue 1, P51-56 2012
DOI: 10.5155/eurjchem.3.1.51-56.500
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Abstract: An efficient synthesis of 7-amino-9-hydroxy-6-oxo-6H-benzo[c]chromene-8-carbonitrile derivatives (2,6) and 4-methyl-2-oxo-2H-chromene-3-carbonitrile (5) via Claisen condensation of 2-hydroxyacetophenones (1,3) with ethyl cyanoacetate in the presence of sodium metal is reported. Reaction of 5 with thiosemicarbazide gave 1-(3-cyano-4-methyl-2oxoquinolin-1(2H)-yl)thiourea (7). Treatment of 5 with 6,8-dichloro-4-oxo-4H-chromene-3carboxaldehyde gave 4-(2-(6,8-dichloro-4-oxo-4H-chromen-3-yl)-2-hydroxyethyl)-2-oxo-2H…

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