Cyclo-oxygenase (COX) inhibitors for preventing preterm labour

Association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes

“…In their systematic review, Kenyon et al 4 reported the highest frequency of antibiotic prophylaxis, showing an association with increased latency period, reduced chorioamnionitis and postpartum endometritis, and decreased neonatal morbidity. Thus, antibiotic prophylaxis has been recommended in preterm PROM cases 9 . However, in this study, no significant difference was observed in the latency period between the groups.…”

Association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes

“…In their systematic review, Kenyon et al 4 reported the highest frequency of antibiotic prophylaxis, showing an association with increased latency period, reduced chorioamnionitis and postpartum endometritis, and decreased neonatal morbidity. Thus, antibiotic prophylaxis has been recommended in preterm PROM cases 9 . However, in this study, no significant difference was observed in the latency period between the groups.…”

Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice

“…The expression of PTGS2 but not PTGS1 is increased at term labor in human gestational tissues such as amnion, choriodecidua and myometrium [ 68 , 69 ]. The administration of PTGS2 (COX-2) inhibitor can effectively suppress LPS-induced PTL [ 70 , 71 ], implying the crucial roles of COX-2-mediated PGs. We proved that the lack of CX3CR1 decreased the intrauterine gene expression of Ptgs2 after LPS treatment.…”

Landscape of Preterm Birth Therapeutics and a Path Forward

“…There is little evidence to suggest COX-inhibitors should be prioritized as effective tocolytics when compared with other available therapeutics; however, some studies have indicated a potential use for NSAIDs in preventing PTB [100]. In 2015, a Cochrane review and meta-analysis evaluated the use of indomethacin for the prevention of PTB [101].…”

Association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes

“…In their systematic review, Kenyon et al 4 reported the highest frequency of antibiotic prophylaxis, showing an association with increased latency period, reduced chorioamnionitis and postpartum endometritis, and decreased neonatal morbidity. Thus, antibiotic prophylaxis has been recommended in preterm PROM cases 9 . However, in this study, no significant difference was observed in the latency period between the groups.…”

Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice

“…The expression of PTGS2 but not PTGS1 is increased at term labor in human gestational tissues such as amnion, choriodecidua and myometrium [ 68 , 69 ]. The administration of PTGS2 (COX-2) inhibitor can effectively suppress LPS-induced PTL [ 70 , 71 ], implying the crucial roles of COX-2-mediated PGs. We proved that the lack of CX3CR1 decreased the intrauterine gene expression of Ptgs2 after LPS treatment.…”

Landscape of Preterm Birth Therapeutics and a Path Forward

“…There is little evidence to suggest COX-inhibitors should be prioritized as effective tocolytics when compared with other available therapeutics; however, some studies have indicated a potential use for NSAIDs in preventing PTB [100]. In 2015, a Cochrane review and meta-analysis evaluated the use of indomethacin for the prevention of PTB [101].…”

Association between antibiotic prophylaxis and adverse perinatal outcomes in premature rupture of membranes

“…In their systematic review, Kenyon et al 4 reported the highest frequency of antibiotic prophylaxis, showing an association with increased latency period, reduced chorioamnionitis and postpartum endometritis, and decreased neonatal morbidity. Thus, antibiotic prophylaxis has been recommended in preterm PROM cases 9 . However, in this study, no significant difference was observed in the latency period between the groups.…”

Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction in mice

“…The expression of PTGS2 but not PTGS1 is increased at term labor in human gestational tissues such as amnion, choriodecidua and myometrium [ 68 , 69 ]. The administration of PTGS2 (COX-2) inhibitor can effectively suppress LPS-induced PTL [ 70 , 71 ], implying the crucial roles of COX-2-mediated PGs. We proved that the lack of CX3CR1 decreased the intrauterine gene expression of Ptgs2 after LPS treatment.…”

Landscape of Preterm Birth Therapeutics and a Path Forward

“…There is little evidence to suggest COX-inhibitors should be prioritized as effective tocolytics when compared with other available therapeutics; however, some studies have indicated a potential use for NSAIDs in preventing PTB [100]. In 2015, a Cochrane review and meta-analysis evaluated the use of indomethacin for the prevention of PTB [101].…”