Cyclins and CDKs in the regulation of meiosis-specific events

Abstract

How eukaryotic cells control their duplication is a fascinating example of how a biological system self-organizes specific activities to temporally order cellular events. During cell cycle progression, the cellular level of CDK (Cyclin-Dependent Kinase) activity temporally orders the different cell cycle phases, ensuring that DNA replication occurs prior to segregation into two daughter cells. CDK activity requires the binding of a regulatory subunit (cyclin) to the core kinase, and both CDKs and cyclins are well conserved throughout evolution from yeast to humans. As key regulators, they coordinate cell cycle progression with metabolism, DNA damage, and cell differentiation. In meiosis, the special cell division that ensures the transmission of genetic information from one generation to the next, cyclins and CDKs have acquired novel functions to coordinate meiosis-specific events such as chromosome architecture, recombination, and synapsis. Interestingly, meiosis-specific cyclins and CDKs are common in evolution, some cyclins seem to have evolved to acquire CDK-independent functions, and even some CDKs associate with a non-cyclin partner. We will review the functions of these key regulators in meiosis where variation has specially flourished.

Phytochemical Investigation of Tecoma capensis Flower Aqueous Extract and In Vitro Biological Studies: Anti‐Bacterial and Anti‐Proliferative Activities of its Silver Nanoparticles

“…The housekeeping gene β‐Actin was used as a reference for normalization. Cyclins and CDKs play essential roles in cell cycle progression, and their complex acts as a protein kinase to initiate specific cell‐cycle processes [55] . CDKs are critical in regulating cell division by modulating the transcription process in response to various extracellular and intracellular signals [56] …”

Glucagon-like peptide-1 analog liraglutide reduces fat deposition in chicken adipocytes

“…Our results demonstrated that GLP-1 suppressed the proliferative activity of preadipocytes. Cell proliferation is influenced by numerous cell cycle regulators, with cyclin D1 and D2 (D3 is not expressed during mitotic clonal expansion), and their catalytic partners, cyclin dependent kinases, playing a pivotal role in cell cycle progression ( Reichart and Eick, 1999 ; Ide et al, 2011 ; Palacios-Blanco and Martín-Castellanos, 2022 ). The present study observed a significant downregulation of cyclin D1 in response to liraglutide.…”