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Cited by 8 publications
(6 citation statements)
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References 6 publications
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“…Cyclins along with cyclin-dependent kinases (CDKs) are absolutely crucial for cell cycle regulation. For example, Cyclin E pairs up with CDK2 to initiate DNA entry into the S-phase and replication ( Fang et al, 2016 ). Thus, dysregulation of CCNE ends up making a cell cancerous.…”
Section: Discussionmentioning
confidence: 99%
“…Cyclins along with cyclin-dependent kinases (CDKs) are absolutely crucial for cell cycle regulation. For example, Cyclin E pairs up with CDK2 to initiate DNA entry into the S-phase and replication ( Fang et al, 2016 ). Thus, dysregulation of CCNE ends up making a cell cancerous.…”
Section: Discussionmentioning
confidence: 99%
“…Its amplification was considered an early genetic event during tumor progression 31. Thus, CCNE1 may present as a target for precision cancer therapy 32.…”
Section: Discussionmentioning
confidence: 99%
“…For instance, CDK2 knockout mice remain viable without apparent abnormalities which suggests that CDK2 inhibitors might selectively kill cancer cells without being toxic to normal cells [ 192 ]. Additionally, in ovary tumors, elevated CCNE1 level is often correlated with higher CDK2 expression [ 195 ]. Deregulation of CDK2 activity is significantly associated with the metastasis of prostate cancer [ 196 ], as well as with the development of other cancer types, including breast cancer [ 197 , 198 ], KRAS-mutant lung cancers [ 199 ], MYCN-amplified neuroblastoma [ 200 ], B-cell lymphomas [ 201 ], Glioblastoma multiforme (GBM) [ 202 ], hepatocellular carcinoma (HCC) [ 203 ], and acute myeloid leukemia (AML) [ 30 ].…”
Section: Role Of Cdks In Cancer Developmentmentioning
confidence: 99%