1996
DOI: 10.1074/jbc.271.34.20608
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: We have previously shown that the persistent activation of p42/p44MAPK is required to pass the G 1 restriction point in fibroblasts (Pagè s, G., Lenormand, P., L'Allemain, G., Chambard, J. C., Meloche, S., and Pouyssé gur, J. Mammalian cells express multiple mitogen-activated protein (MAP) 1 kinases that mediate the effects of extracellular signals on a wide array of biological processes. In eukaryotic cells, three distinct MAPK cascades have been described, which appear to be linked to separate signal trans… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

59
817
10
16

Year Published

1998
1998
2007
2007

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 1,159 publications
(902 citation statements)
references
References 62 publications
59
817
10
16
Order By: Relevance
“…Erk kinase facilitates S-phase DNA damage checkpoint D Wu et al at 50 mM slightly reduced G1-phase progression, an observation consistent with a role of Erk kinase in the facilitation of G1 Cdk activation (Lavoie et al, 1996;Weber et al, 1997;Cheng et al, 1998), U0126 attenuated HU-induced S-phase arrest in MCF7, MEF, NIH3T3, and HCT116 cells (Table 1). Another MEK inhibitor, PD98059, essentially produced the same results (data not shown), suggesting a general role for Erk in DNA damage-induced S-phase checkpoint activation.…”
Section: Hu Activates Erk Kinase Via Mek1supporting
confidence: 66%
“…Erk kinase facilitates S-phase DNA damage checkpoint D Wu et al at 50 mM slightly reduced G1-phase progression, an observation consistent with a role of Erk kinase in the facilitation of G1 Cdk activation (Lavoie et al, 1996;Weber et al, 1997;Cheng et al, 1998), U0126 attenuated HU-induced S-phase arrest in MCF7, MEF, NIH3T3, and HCT116 cells (Table 1). Another MEK inhibitor, PD98059, essentially produced the same results (data not shown), suggesting a general role for Erk in DNA damage-induced S-phase checkpoint activation.…”
Section: Hu Activates Erk Kinase Via Mek1supporting
confidence: 66%
“…In association with their binding partners, cdk 4 and 6, D-type cyclins promote G 0 -G 1 to S-phase transition by activating phosphorylation of pRb, thereby helping to cancel its growth-repressive function (Matsushime et al, 1992). Ample evidence supports the role of cyclin D in mitogenic signaling: for example mitogenic pathways (for example, RAS and ERK1/2) positively regulate expression of D-type cyclins (Lavoie et al, 1996). Hence, decreased expression of cyclin D1 in DPI-treated cells (Figure 10a) is consistent with decreased activity of ERK1/2 in these cells (Figure 10a) and induction of the G 1 checkpoint (Figures 1b and 6a).…”
Section: Discussionmentioning
confidence: 99%
“…One of the mechanisms through which MKK3/p38MAPK can arrest cell growth and induce apoptosis is through its e ect on cyclin D1 expression during cell cycle. It has been demonstrated that the coexpression of MKK3 along with p38MAPK inhibits mitogen-induced cyclin D1 expression (Lavoie et al, 1996).…”
Section: Map Kinase Kinase-3mentioning
confidence: 99%