Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with clinicopathological features

Patil, Gururaj B.; Hallikeri, Kaverı; Balappanavar, Aswini Y; Hongal, Sudheer; Sanjaya, PR; Sagari, Sheetalkumar G.

doi:10.4317/medoral.18220

Cited by 14 publications

(8 citation statements)

References 16 publications

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“…Meanwhile, P27 Kip1 is inversely related to GC and its decreased expression is reported as a negative prognostic marker in GC [ 89 – 91 ]. Cyclin B1 regulates the cell cycle transition from G2 to M phase [ 92 ] and plays key roles in cell differentiation, apoptosis, and metastasis [ 93 – 97 ]. And its expression might be relevant to the poor outcome of GC patients [ 98 – 101 ].…”

Section: Resultsmentioning

confidence: 99%

Network Pharmacology‐Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer

Liu

Zhang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Background Hedyotis diffusa Willd. (HDW) is one of the renowned herbs often used in the treatment of gastric cancer (GC). However, its curative mechanism has not been fully elucidated. Objective To systematically investigate the mechanisms of HDW in GC. Methods A network pharmacology approach mainly comprising target prediction, network construction, and module analysis was adopted in this study. Results A total of 353 targets of the 32 bioactive compounds in HDW were obtained. The network analysis showed that CA isoenzymes, p53, PIK3CA, CDK2, P27Kip1, cyclin D1, cyclin B1, cyclin A2, AKT1, BCL2, MAPK1, and VEGFA were identified as key targets of HDW in the treatment of GC. The functional enrichment analysis indicated that HDW probably produced the therapeutic effects against GC by synergistically regulating many biological pathways, such as nucleotide excision repair, apoptosis, cell cycle, PI3K/AKT/mTOR signaling pathway, VEGF signaling pathway, and Ras signaling pathway. Conclusions This study holistically illuminates the fact that the pharmacological mechanisms of HDW in GC might be strongly associated with its synergic modulation of apoptosis, cell cycle, differentiation, proliferation, migration, invasion, and angiogenesis.

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Section: Resultsmentioning

confidence: 99%

Network Pharmacology‐Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer

Liu

Zhang

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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“…Cancer cells often have an abnormal mitotic cycle. Cell proliferation, differentiation, senescence and apoptosis are closely related to the cell cycle regulatory machinery (51). The markers associated with the dysregulation of the cell cycle machinery usually indicate cancer progression.…”

Section: Molecular Mechanismsmentioning

confidence: 99%

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Peng

Wang

Quan

et al. 2016

International Journal of Oncology

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Abstract. Oral verrucous carcinoma (OVC) is a verrucous variant of oral squamous cell carcinoma (OSCC), which accounts for 2-12% of all oral carcinomas with a 5-year survival rate of only approximately 50%. Enormous effort has been dedicated to this cancer, and the past decades have witnessed significant advances in relevant diagnostic and therapeutic approaches. Currently, there exist three challenges from primary sub-fields of research and clinical practice of the cancer, namely multifactorial etiology, complex molecular mechanism, and deficient treatment. This study reviews the existing literature on the cancer, encompassing its etiology, clinical manifestations and pathology, molecular mechanism, diagnosis and differential diagnosis, and treatment. For improved treatment of OVC, multifactorial etiology analysis, incorporation of effective biomarkers for mechanism illustration, and integration of multidisciplinary modalities are expounded, in an attempt to resolve the challenges and to provide a useful guide for future research in the field.

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“…This detection point cannot detect whether the DNA is damaged, whereas the damaged DNA to continue to undergo mitosis; and it would also cause the proteasome to break down and recognize all MPF in the middle stage of division, resulting in continuous proliferation and development of tumor cells [50]. CCNB1 and squamous cells build on each other, allowing cancer cells to proliferate and differentiate, while new cancer cells promote the expression of CCNB1 to further increase [51]. Previous studies have reported that KIAA0101 overexpression in mammalian cells can prevent UV-induced apoptosis, suggesting its essential role in regulating DNA repair, cell proliferation, apoptosis and cell cycle progression [52].…”

Section: Discussionmentioning

confidence: 99%

Screening and Identification of Novel Biomarkers Associated with Cutaneous Squamous Cell Carcinoma

Huang

Han

et al. 2020

Preprint

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Background: Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in patients with non-melanoma skin cancers (NMSC). However, unclear pathogenesis of cSCC limits the application of molecular targeted therapy. Results: To identify the hub genes in the pathogenesis and progression of cSCC, we downloaded the microarray data sets GSE2503, GSE45164 and GSE66359 from the Gene Expression Omnibus (GEO) database, and identified differentially expressed genes (DEGs) between tumor and non-tumor tissues. Functional enrichment analysis was performed using DAVID. The STRING online website was used to construct a protein-protein interaction network (PPI), and then Cytoscape performed module analysis and degree calculation. 146 DEGs were identified with significant differences, including 113 up-regulated genes and 33 down-regulated genes. The enriched functions and pathways of the DEGs include microtubule-based movement, ATP binding, cell cycle, p53 signaling pathway, oocyte meiosis and PLK1 signaling events. Nine hub genes were identified, namely CDK1, AURKA, RRM2, CENPE, CCNB1, KIAA0101, ZWINT, TOP2A, ASPM. The differential expression of these genes has been verified in other data sets. In addition, the ROC curve also confirmed their ability to predict disease. Conclusion: By integrated bioinformatic analysis, the DEGs and hub genes identified in this study elucidated the molecular mechanism of the pathogenesis and progression of cSCC, and are expected to become future biomarkers or therapeutic targets.

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Cyclin B1 overexpression in conventional oral squamous cell carcinoma and verrucous carcinoma- A correlation with clinicopathological features

Cited by 14 publications

References 16 publications

Network Pharmacology‐Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer

Network Pharmacology‐Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer

Oral verrucous carcinoma: From multifactorial etiology to diverse treatment regimens (Review)

Screening and Identification of Novel Biomarkers Associated with Cutaneous Squamous Cell Carcinoma

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