Cyclic topology enhances the killing activity of polycations against planktonic and biofilm bacteria

Wu, Bin; You, Wei; Wang, Haili; Zhang, Ze; Nie, Xuan; Wang, Fei; You, Ye‐Zi

doi:10.1039/d2tb00194b

Cited by 5 publications

(2 citation statements)

References 56 publications

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“…H&E and Masson's trichrome staining of residual wounds were used to evaluate the wound healing process. 51…”

Section: In Vivo Antibacterial Activity and Wound Healing Property Testmentioning

confidence: 99%

An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

Yu,

Huang,

Wang

et al. 2024

J. Mater. Chem. B

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“…H&E and Masson's trichrome staining of residual wounds were used to evaluate the wound healing process. 51…”

Section: In Vivo Antibacterial Activity and Wound Healing Property Testmentioning

confidence: 99%

An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

Yu,

Huang,

Wang

et al. 2024

J. Mater. Chem. B

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“…Polymers with quaternized amino groups were reported to be effective non-specific biocides with serious benefits compared to conventional low-molecular-weight antibacterial agents. Polycations do not cause the development of induced tolerance of the bacteria and do not give rise to mutant species [23]. Among commercially available polycations, polydiallyldimethylammonium chloride (PDADMAC) is of great potential [24,25].…”

Section: Introductionmentioning

confidence: 99%

Biocidal Coatings against Gram-Positive Bacteria from Linear and Branched Polycations: The Decisive Role of the Diffusion Coefficients of Macromolecules

et al. 2023

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Positively charged polyelectrolytes hold significant potential as materials for creating antibacterial coatings. We examined the physicochemical and mechanical properties of the macromolecules in water solutions and in coatings for the series of branched polyethyleneimine (PEI) and linear polydiallyldimethylammonium chloride (PDADMAC) with different molecular weights. The microbiological study was conducted to analyze the biocidal activity of the polycation solutions and coatings towards foodborne bacteria. While the moisture saturation of the polycationic coatings and biocidal activity did not significantly depend on the chemical nature of charged groups or the molecular weight or architecture of macromolecules, the lowering of the molecular weight of polymers resulted in the loss of cohesive forces in the coatings and to a dramatic loss of stability when being washed off with water. The diffusion coefficient (D0) of macromolecules was identified as a key parameter for the wash-off mechanism. Films formed by molecules with a D0 below 1 × 10−7 cm2/s demonstrated a high resistance to wash-off procedures. We demonstrated that PEI and PDADMAC samples with high molecular weights showed high antimicrobial activity towards L. monocytogenes. Our results highlight the importance of macromolecule characteristics in the development of new biocidal coatings based on polycations.

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Infection‐responsive polysaccharide‐based drug‐loaded nano‐assembly for dual‐modal treatment against drug‐resistant bacterial lung infection

Han,

Yuan,

Ren

et al. 2024

BMEMat

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The escalating issue of lung infections induced by multi‐drug resistant (MDR) bacteria is threatening human health. Thus, the development of efficient drug delivery systems is essential to eliminate MDR bacterial lung infections effectively. Herein, we designed inhalable drug‐loaded nano‐assemblies by the electrostatic interaction between negatively charged sodium alginate and a positively charged antibacterial polymer, quaternized polyethyleneimine (QPEI‐C6), as well as a kind of typical antibiotic for therapy of lung infection, azithromycin (AZT). By adjusting the feed ratios, we optimized the size of the nano‐assembly to approximately 200 nm (STQ12), which was beneficial for penetration through the mucus layer and biofilm. In the slightly acidic environment of the infected site, the nano‐assembly could dissemble responsively and release AZT and QPEI‐C6. Because of the combined bactericidal effect, STQ12 exhibited high bactericidal efficiency against MDR bacteria. In animal experiments, STQ12 showed notable efficacy against MDR bacterial lung infection. Gene transcriptomic results showed that the main effects of STQ12 against bacteria were through influencing the bacterial cell components and metabolic processes, and affecting their growth and reproduction. This work provides a promising strategy to treat MDR bacterium‐induced lower respiratory tract infections.

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Cyclic topology enhances the killing activity of polycations against planktonic and biofilm bacteria

Abstract: We showed the enhanced killing activity of cyclic polycation against planktonic bacteria due to higher local charge density and enhanced bactericidal effect in biofilm owing to smaller hydrodynamic volume than linear analogues.

Cited by 5 publications

References 56 publications

An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

Biocidal Coatings against Gram-Positive Bacteria from Linear and Branched Polycations: The Decisive Role of the Diffusion Coefficients of Macromolecules

Infection‐responsive polysaccharide‐based drug‐loaded nano‐assembly for dual‐modal treatment against drug‐resistant bacterial lung infection

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