Cyclic stretch induced miR-146a upregulation delays C2C12 myogenic differentiation through inhibition of Numb

Dynamic Expression of Specific miRNAs during Erythroid Differentiation of Human Embryonic Stem Cells

“…miR-146a is known to suppress metastasis (Edmonds et al, 2009;Li et al, 2010) and more recently it has also been implicated in modulating immune responses (Tsitsiou and Lindsay, 2009;Williams et al, 2008). miR-451 plays a role in regulating erythropoiesis by repressing negative regulators for erythropoiesis, such as Gata2 (Dore et al, 2008;Kuang et al, 2009;Zhan et al, 2007). However, it is largely unknown whether these miRNAs are involved in early stages of hematopoiesis.…”

MicroRNAs Are Essential for Stretch-induced Vascular Smooth Muscle Contractile Differentiation via MicroRNA (miR)-145-dependent Expression of L-type Calcium Channels

“…As of yet, no reports have investigated the importance of miRNAs for stretch-induced contractile differentiation of vascular smooth muscle, and the mechanisms of miR-145-dependent actin polymerization are not completely defined. However, recent studies have identified specific miRNAs involved in stretch-dependent effects of skeletal muscle and airway smooth muscle, indicating that miRNAs may play a role in cellular mechanosensing (24,25).…”

MicroRNAs: Novel components in a muscle gene regulatory network

“…For instance, miR-181 negatively regulates skeletal myogenesis by targeting the homeobox protein Hox-A11, which in turn represses MyoD by a mechanism that has not yet been fully revealed. 45,46 On the other hand, miR-146a 47 and miR-26a 48 each act as positive regulators of myogenesis by either modulating the expression of the Notch-1 inhibitor, Numb, 47 or by targeting the polycomb complex member Ezh2 that contributes to chromatin silencing of skeletal muscle genes. 48,49 Furthermore, miR-195, miR-21 and miR-18b have all recently been linked to cardiac hypertrophy.…”