volume 242, issue 1, P63-66 1985
DOI: 10.1007/bf00464408
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Abstract: We found that the cyclic-adenosine-3',5'-monophosphate (cAMP) contents of otosclerotic human ossicles were 40-50 times greater than basal levels. Cyclic-guanosine-3',5'-monophosphate (cGMP) levels were also found to be greater than in physiological conditions, but lower than in cortical bone. These findings suggest the extensive participation of these nucleotide coenzymes in effector cells during the process of bone resorption. This emphasizes the role of bone-resorbing cells in this process as well as the pro…

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