Biochemical Pharmacology volume 78, issue 4, P396-405 2009 DOI: 10.1016/j.bcp.2009.04.030 View full text
Lirlândia P. Sousa, Aline F. Carmo, Bárbara M. Rezende, Fernando Lopes, Douglas M. Silva, Ana L. Alessandri, Cláudio A. Bonjardim, Adriano G. Rossi, Mauro M. Teixeira, Vanessa Pinho

Abstract: Selective and timely induction of apoptosis is an effective means of resolving inflammation. The effects and putative mechanisms by which cyclic AMP (cAMP) modulates leukocyte apoptosis in vivo are still unclear. The present study aims at identifying intracellular pathways underlying the ability of cAMP elevating agents to resolve eosinophilic inflammation in a model of allergic pleurisy in mice. Ovalbumin (OVA) challenge of immunized mice induced eosinophil recruitment that peaked at 24h and persisted till 48…

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