2005
DOI: 10.1083/jcb.200505117
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Abstract: The host hormone melatonin increases cytoplasmic Ca2+ concentration and synchronizes Plasmodium cell cycle (Hotta, C.T., M.L. Gazarini, F.H. Beraldo, F.P. Varotti, C. Lopes, R.P. Markus, T. Pozzan, and C.R. Garcia. 2000. Nat. Cell Biol. 2:466–468). Here we show that in Plasmodium falciparum melatonin induces an increase in cyclic AMP (cAMP) levels and cAMP-dependent protein kinase (PKA) activity (40 and 50%, respectively).When red blood cells infected with P. falciparum are treated with cAMP analogue adenosine… Show more

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Cited by 124 publications
(140 citation statements)
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“…These findings are of major significance, because they raise the possibility that chloroquine and artemisinin action in malaria parasites may involve alterations in ion homeostasis. This is especially important in view of our work showing that IP 3 -dependent Ca 2+ signaling is involved in the progression of the malarial parasite cell cycle (Hotta et al 2000, Gazarini et al 2003, Beraldo et al 2005.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These findings are of major significance, because they raise the possibility that chloroquine and artemisinin action in malaria parasites may involve alterations in ion homeostasis. This is especially important in view of our work showing that IP 3 -dependent Ca 2+ signaling is involved in the progression of the malarial parasite cell cycle (Hotta et al 2000, Gazarini et al 2003, Beraldo et al 2005.…”
Section: Discussionmentioning
confidence: 99%
“…We have reported the existence of Ca 2+ pools in the acidic compartment of rodent as well as human malaria parasites as a possible mechanism for the regulation of calcium concentration in these parasites , Passos & Garcia 1998. Calcium homeostasis in malaria parasites has been extensively studied by several authors (Tanabe et al 1982, Krungkrai & Yuthavong 1983, Scheibel et al 1987, Wasserman et al 1990, Adovelande et al 1993, Garcia et al 1997, Gazarini et al 2003, Gazarini & Garcia 2004, Beraldo et al, 2005, Budu et al 2007). Interestingly, in P. chabaudi, the second messenger IP 3 , mobilizes Ca 2+ not only from the classical ER-like pool but also from an acidic compartment, implying that these parasites utilize a calcium-mediated cell signaling mechanism similar to higher organisms (Passos & Garcia 1998).…”
mentioning
confidence: 99%
“…Many of these phosphorylations were on sites within their activation loops and therefore potentially associated with the regulation of catalytic activity [66]. These include, in addition to PfGSK3 and PfCLK3 already discussed, activation loop phosphorylation of the cyclic nucleotide-dependent kinases PfPKA (PFI1685w) and PfPKG (PF14_0346) [19], both of which have crucial functions in the erythrocytic cycle [54,[67][68][69][70]. How are these kinases regulated?…”
Section: Plasmodium Phosphoproteomicsmentioning
confidence: 99%
“…The present data demonstrates that the presence of various concentrations of melatonin, serotonin, N-acetyl-serotonin (NAS) and tryptamine led to an increase in the percentage of multinucleated schizont forms of parasites, favoring synchronization of intraerythrocytic cycle of P. falciparum. As to the molecular mechanism of melatonin action, the hormone and its precursors N-acetylserotonin, tryptamine, serotonin and N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) were able to induce intracellular Ca 21 transients in P. falciparum and P. chabaudi and these responses were blocked by PLC inhibition and luzindole (9,30,31). Such effects were not observed in P. berghei and P. yoelii, rodent parasites with asynchronous development of intraerythrocytic stages in vivo.…”
Section: Resultsmentioning
confidence: 99%