Cyclic adenosine 3′,5′-monophosphate-phosphodiesterases in epididymis and prostate of castrate and of aged rats

The relationship of phosphodiesterase 5 inhibitors and male fertility: literature review

“…Фосфодиэстеразы были обнаружены в гладкомышечных и миофибробластных клетках семенных канальцев, а также придатков яичка и эфферентных протоков быка и крысы [1][2][3][4][5]. Эти клетки могут сокращаться, тем самым ускоряя созревание сперматозоидов за счет транспортировки неподвижных сперматозоидов яичка к хвостовой части придатка яичка.…”

PDE5 inhibitors and male reproduction: Is there a place for PDE5 inhibitors in infertility clinics or andrology laboratories?

“…PDEs have been discovered in the smooth muscle and myofibroblast cells (i.e., the phenotype of that latter being somewhere between a smooth muscle and a fibroblast cell) of seminiferous tubules and both epididymal and efferent ducts in the bull (Table 1) and the rat (Table 2). 12–16 These contractile cells augment sperm maturation through testicular immotile spermatozoa conveyance to the cauda epididymis 15 . Additionally, spermatogenesis in the human testis is affected by the peritubular lamina propria.…”