Cyanocobalamin (vitamin B-12) status in Seventh-day Adventist ministers in Australia

Hokin, Bevan; Butler, Terry

doi:10.1093/ajcn/70.3.576s

Cited by 42 publications

(24 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a cross-sectional survey [26], serum concentrations of vitamin B 12 that were lower than the normal value were observed in 73% of the vegetarian subjects who were not taking vitamin B 12 supplements. In this study [26], deficient vitamin B 12 intake was responsible for the low B 12 serum concentration in both LOV and vegans. Thus, it is reasonable to assume that our vegetarian subjects may have had high tHcy values because of their low vitamin B 12 intake.…”

Section: Discussionmentioning

confidence: 93%

“…On the other hand, it has been shown that vegetarians, and particularly vegans, have low blood levels of vitamin B 12 [25]. In a cross-sectional survey [26], serum concentrations of vitamin B 12 that were lower than the normal value were observed in 73% of the vegetarian subjects who were not taking vitamin B 12 supplements. In this study [26], deficient vitamin B 12 intake was responsible for the low B 12 serum concentration in both LOV and vegans.…”

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Effect of Vegetarian Diet on Homocysteine Levels

Bissoli¹,

Francesco²,

Ballarin³

et al. 2002

Ann Nutr Metab

View full text Add to dashboard Cite

Objective: To compare fasting total plasma homocysteine (tHcy) levels in vegans, lacto-ovovegetarians and control subjects, and to evaluate the relationships between tHcy levels and nutritional variables in vegetarians. Methods: The study was conducted on 45 vegetarian subjects: 31 vegans (19 males, 12 females, mean age 45.8 ± 15.8 years); 14 lacto-ovovegetarians (6 males, 8 females, mean age 48.5 ± 14.5 years), and 29 control subjects (19 males, 10 females, mean age 43.4 ± 16.7 years). tHcy was evaluated by high-performance liquid chromatography. Serum vitamin B₁₂ and folate were analyzed by automated chemiluminescence systems. Clinical records, nutritional and anthropometric variables were collected for all vegetarian subjects. Results: tHcy was significantly higher in vegetarian subjects than in controls (23.9 ± 21.3 vs. 11.6 ± 4.9 µmol/l, p < 0.001). The prevalence of hyperhomocysteinemia was higher in vegetarians than in controls (53.3 vs. 10.3%, p < 0.001). Serum vitamin B₁₂ levels were lower in vegetarians than in control subjects (171.2 ± 73.6 vs. 265.0 ± 52.2 pmol/l, p < 0.01; normal range 220–740 pmol/l). In vegetarian subjects, significant inverse correlations were found between tHcy and serum vitamin B₁₂ levels (r = –0.776, p < 0.001) and between tHcy and serum folate levels (r = –0.340, p < 0.05). Positive correlations were found between tHcy and mean red cell volume (r = 0.44, p < 0.01) and between tHcy and fat-free mass (r = 0.36, p < 0.05). Conclusion: Vegetarian subjects presented significantly higher tHcy levels, higher prevalence of hyperhomocysteinemia, and lower serum vitamin B₁₂ levels than controls.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 98%

Effect of Vegetarian Diet on Homocysteine Levels

Bissoli¹,

Francesco²,

Ballarin³

et al. 2002

Ann Nutr Metab

View full text Add to dashboard Cite

show abstract

“…Subnormal vitamin B-12 status is prevalent (50%–70%) in vegetarians or vegans in Austria Germany, Italy, Australia, India and China [45,46,47,48,49,50,51,52]. There has been some controversy about the definition of vitamin B-12 deficiency because of variability in clinical manifestation.…”

Section: Metabolic Vitamin B-12 Deficiency With Vegan or Related Dmentioning

confidence: 99%

Vegan Diet, Subnormal Vitamin B-12 Status and Cardiovascular Health

2014

View full text Add to dashboard Cite

Vegetarian diets have been associated with atherosclerosis protection, with healthier atherosclerosis risk profiles, as well as lower prevalence of, and mortality from, ischemic heart disease and stroke. However, there are few data concerning the possible cardiovascular effects of a vegan diet (with no meat, dairy or egg products). Vitamin B-12 deficiency is highly prevalent in vegetarians; this can be partially alleviated by taking dairy/egg products in lact-ovo-vegetarians. However, metabolic vitamin B-12 deficiency is highly prevalent in vegetarians in Australia, Germany, Italy and Austria, and in vegans (80%) in Hong Kong and India, where vegans rarely take vitamin B-12 fortified food or vitamin B-12 supplements. Similar deficiencies exist in northern Chinese rural communities consuming inadequate meat, egg or dairy products due to poverty or dietary habits. Vascular studies have demonstrated impaired arterial endothelial function and increased carotid intima-media thickness as atherosclerosis surrogates in such metabolic vitamin B-12 deficient populations, but not in lactovegetarians in China. Vitamin B-12 supplementation has a favourable impact on these vascular surrogates in Hong Kong vegans and in underprivileged communities in northern rural China. Regular monitoring of vitamin B-12 status is thus potentially beneficial for early detection and treatment of metabolic vitamin B-12 deficiency in vegans, and possibly for prevention of atherosclerosis-related diseases.

show abstract

“…This is similar to study conducted in Seventh-day Adventist ministers in Australia by Hokin BD et al in 245 vegetarians where serum level of vitamin B 12 below the reference range of study (126-627 pg/ml) was 53%. 14 The Marwari population have a high life style and standard of living comparable to Adventist minister of Australia. Similar reports of high prevalence of vitamin B 12 deficiency in vegetarians have been shown in different studies.…”

Section: Discussionmentioning

confidence: 99%

Study of vitamin B12 status and the consequential clinico-hematological profile in healthy vegetarian population in Nepal

Paudel

Agrawal²,

Timilsena

et al. 2017

J Chitwan Med Coll

View full text Add to dashboard Cite

Background: A strict vegetarian diet has been associated with an increased risk of vitamin B12 deficiency. Clinical manifestations of cobalamin deficiency are hematologic and neurological symptoms. The purpose of this study was to determine the prevalence of vitamin B12 deficiency in healthy vegetarian population and to study the clinical and hematological profile of vitamin B12 deficient subjects. Methods: A community based cross-sectional observational study was conducted through preplanned camps in Kathmandu Nepal. 166 vegetarian people were investigated for serum vitamin B12 level and their hematological profile was done. They were examined for neurological manifestation of vitamin B12 deficiency. Results: The mean serum vitamin B12 level of the vegetarian in this study was 271.34 ±241.74 pg/ml (mean ± SD)., 53.6 % had serum vitamin B12 deficiency. 56.5 % of male and 47.1 % of female had vitamin B12 deficiency. The risk of vitamin B12 deficiency is more in males than females with odds ratio 1.201 (CI=95%) which is not statistically significant with p-value 0.312. There was no significant difference in vitamin B12 level in different age group.The study population had mean hemoglobin of 13.12 ± 1.72 gm/dl. Anemia was present in 34.9 % of study population. 33.9 % of male and 37.3 % of female had anemia. There was no significant difference in anemia in male and female vegetarian (p-value 0.72). 40% of patient who had vitamin B12 deficiency had anemia.A significant low hemoglobin level and higher MCV were found as level of serum vitamin B12 decreased. Only one patient had macrocytic anemia.There were few symptoms but not specific to vitamin B12 deficiency. Conclusion: The result of present study show that prevalence of vitamin B12 deficiency among healthy vegetarian was 53.6% with higher prevalence in male and elder age group.Prevalence of anemia was 34.9% in this study with elderly group and females being more affected.There was significant correlation between vitamin B12 and hemoglobin level and significant negative correlation with MCV. Although, not significant, leucocytes count, lymphocyte count and platelets were low in vitamin B12 deficient population.Few clinical features were present in vitamin B12 deficient subjects but neurological features specific to vitamin B12 deficiency were not seen.

show abstract

Cyanocobalamin (vitamin B-12) status in Seventh-day Adventist ministers in Australia

Cited by 42 publications

References 2 publications

Effect of Vegetarian Diet on Homocysteine Levels

Effect of Vegetarian Diet on Homocysteine Levels

Vegan Diet, Subnormal Vitamin B-12 Status and Cardiovascular Health

Study of vitamin B12 status and the consequential clinico-hematological profile in healthy vegetarian population in Nepal

Contact Info

Product

Resources

About