Cyanoacrylate Tissue Adhesives: An Experimental and Clinical Evaluation

Matsumoto, Teruo; Nemhauser, Gary M.; Soloway, Henry B.; Heisterkamp, Charles A.; Aaby, Gene V.

doi:10.1093/milmed/134.4.247

Cited by 38 publications

(8 citation statements)

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“…As with polymethylmethacrylate the presence of cyanoacrylate in fracture gaps has been shown to act as a physical barrier to fracture healing (50,53,54,56,57,82). A similar physical interference with wound healing has been reported following repair of skin incisions with cyanoacrylates (60,62). When used in limited quantities, healing of fractures occurs around the adhesive (50,53,54,56,57,66).…”

Section: Discussionsupporting

confidence: 53%

“…butyl forms) are degraded slowly and are much less reactive (47, 50, 54-57, 60, 62-64, 69, 71). It has also been shown that they lack immunosuppressive effects, and have not been found to induce neoplasms (46,62,71). Polymerization occurs when the liquid monomer comes into contact with anionic initiators such as the hydroxyl groups found in water, or amino groups of proteins (47,59,63).…”

Section: Discussionmentioning

confidence: 99%

“…The longer side chain cyanoacrylates have been evaluated in a wide variety of clinical and experimental settings. Their use in human medicine has included arteriovenous malformation and tumour embolization, intestinal and vascular anastamosis, repair of skin lacerations, skin and mucosal grafting, treatment of corneal ulcers, haemostasis in maxillofacial wounds, contaminated wounds, hepatic parenchymal bleeding and others (51,52,62,69,71). Their use in clinical veterinary medicine in comparison has been limited.…”

Section: Discussionmentioning

confidence: 99%

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Avian Fracture Healing Following Stabilization with Intramedullary Polyglycolic Acid Rods and Cyanoacrylate Adhesive vs. Polypropylene Rods and Polymethylmethacrylate

Mathews¹,

Wallace²,

Redig³

et al. 1994

Vet Comp Orthop Traumatol

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SummaryAvian fracture healing was evaluated for twelve weeks following the repair of transverse mid-diaphyseal humeral fractures. Radiographic, histological, and biomechanical assessment of healing was used to compare a currently used method of repair - a permanent intramedullary polypropylene rod and polymethylmethacrylate bone cement, to a new biodegradable repair technique which utilized intramedullary polyglycolic acid rods and cyanoacry-late adhesive. Histological response to the biodegradable implants consisted of a granulomatous foreign body reaction that did not impair fracture healing. Fibrous encapsulation occurred around the permanent devices. Biodegradable repairs developed more periosteal callus, and early complications were more common following biodegradable repair, but there was little difference between the two groups biomechanically. Polyglycolic acid implants appear to be viable alternatives for the repair of some avian fractures. Investigation into the use of other biodegradable polymers for avian fracture fixation is warranted.Avian fracture healing following the repair of trans-verse humeral fractures with intramedullary biodegradable polyglycolic acid (PGA) rods and cyanoacrylate adhesive was compared to healing following repair with polypropylene rods and polymethylmethacrylate (PMMA) bone cement. Foreign body reaction to the PGA/cyanoacrylate fixation occurred, but did not impair fracture healing. Biomechanical testing revealed few differences between the two fixation methods at 0-12 weeks following fracture repair.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Avian Fracture Healing Following Stabilization with Intramedullary Polyglycolic Acid Rods and Cyanoacrylate Adhesive vs. Polypropylene Rods and Polymethylmethacrylate

Mathews¹,

Wallace²,

Redig³

et al. 1994

Vet Comp Orthop Traumatol

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“…From 1960 to the early 70s there were many investigations into their clinical uses, especially for incision repair and hemostatic use [2, 3, 4]. Many of the early compounds had problems with toxicity [5, 6].…”

Section: Introductionmentioning

confidence: 99%

The Effect of a New Tissue-Adhesive Wound Dressing on the Healing of Traumatic Abrasions

Quinn¹,

Lowe

Mertz³

2000

Dermatology

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Background: Octylcyanoacrylate is a new medical-grade adhesive with antimicrobial properties. It forms a thin, flexible, occlusive bandage. Objective: To determine the gross and histological effects of the spray bandage when treating abrasions. Methods: Abrasions were produced on the flanks of 18 albino guinea pigs and randomized to treatment with a control (Biobrane) or octylcyanoacrylate dressing. The wounds were assessed with digital photography using a previously validated method. Histopathological analysis was done on day 14. Results: There were no differences in the mean wound-healing ratios on days 1 (1.25 vs. 1.23, p = 0.61), 7 (1.15 vs. 1.13, p = 0.14) and 14 (1.03 vs. 1.02, p = 0.63) for tissue adhesive and Biobrane, respectively. There were no differences found on histopathological analysis either. Conclusions: This external spray bandage was well tolerated and did not show any signs of histotoxicity or adverse wound healing.

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“…NBCA induces an inflammatory exudate, and this is followed by granulation tissue that grows around the fragments of the polymer and results in luminal occlusion, scarring, and tissue atrophy. 10 Our patient presented with a bile leak that originated from an isolated segmental hepatic duct system. We believe that this isolated duct was missed at the time of the hepaticojejunostomy partly because the hepaticojejunostomy was performed high up in the hilum with multiple ducts.…”

mentioning

confidence: 86%

Segmental biliary ductN-butyl cyanoacrylate ablation in a transplant liver for a biliary leak after hepaticojejunostomy

et al. 2014

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Cyanoacrylate Tissue Adhesives: An Experimental and Clinical Evaluation

Cited by 38 publications

References 0 publications

Avian Fracture Healing Following Stabilization with Intramedullary Polyglycolic Acid Rods and Cyanoacrylate Adhesive vs. Polypropylene Rods and Polymethylmethacrylate

Avian Fracture Healing Following Stabilization with Intramedullary Polyglycolic Acid Rods and Cyanoacrylate Adhesive vs. Polypropylene Rods and Polymethylmethacrylate

The Effect of a New Tissue-Adhesive Wound Dressing on the Healing of Traumatic Abrasions

Segmental biliary ductN-butyl cyanoacrylate ablation in a transplant liver for a biliary leak after hepaticojejunostomy

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