CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver

Guillemot, E.; Karimdjee-Soilihi, Babou; Pradelli, Emmanuelle; Benchetrit, Maxime; Goguet, Emilie; Ma, Millet; Larbret, Frédéric; Jf, Michiels; Birnbaum, Daniel; Alemanno, Pamela; Schmid-Antomarchi, Heidy; Schmid-Alliana, Annie

doi:10.1038/bjc.2012.503

Cited by 41 publications

(53 citation statements)

References 32 publications

(54 reference statements)

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“…Some studies have shown that CXCR-7 and IL-8 can contribute to tumor proliferation and metastasis in renal cell carcinoma (22). Activation of CXCR7 on tumor blood vessels facilitates the progression of colon cancer with lung metastasis (23). High expression of CXCR7 also leads to progression, metastasis and angiogenesis in brain tumors, and regulates the transendothelial migration in lymphoma (24,25).…”

Section: Discussionmentioning

confidence: 99%

Knockdown of CXCR7 inhibits proliferation and invasion of osteosarcoma cells through inhibition of the PI3K/Akt and β-arrestin pathways

et al. 2014

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Abstract. CXC chemokine receptor 7 (CXCR7) has been implicated in tumor development and metastasis in multiple malignancies. Yet, the function and molecular mechanisms of CXCR7 in human osteosarcoma (OS) are still unclear. The aim of the present study was to investigate the role of CXCR7 in human OS. The expression of CXCR7 was assessed by immunohistochemical assay using a tissue microarray procedure in 45 cases of OS tissues. A loss-of-function approach was used to observe the effects of lentiviral vector-mediated CXCR7 siRNA (Lv-siCXCR7) on biological behaviors including proliferative activities and invasive potential, as indicated by MTT and Transwell assays in OS (MG-63 and U-2 OS) cells. The results showed that the expression of CXCR7 protein in OS tissues was significantly increased compared to that in adjacent non-cancerous tissues (68.9 vs. 53.3%, P=0.033), and was correlated with the distant metastasis of the tumors (P=0.004). Knockdown of CXCR7 suppressed proliferation and invasion of OS cells through decreased expression of PI3K, AKT, β-arrestin, proliferating cell nuclear antigen (PCNA), and matrix metalloproteinase-9 (MMP-9). In addition, the tumor volume in U-2 OS subcutaneous tumor models treated with Lv-siCXCR7 was significantly smaller than the tumor volume in the negative control group (P<0.01). Collectively, our findings indicate that upregulation of CXCR7 expression is correlated with distant metastasis of OS, while knockdown of CXCR7 blocks the development of OS cells through inhibition of the PI3K/AKT and β-arrestin pathways, suggesting that CXCR7 may serve as a potential therapeutic target for the treatment of cancer.

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Section: Discussionmentioning

confidence: 99%

Knockdown of CXCR7 inhibits proliferation and invasion of osteosarcoma cells through inhibition of the PI3K/Akt and β-arrestin pathways

et al. 2014

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“…CXCR7, as a recently discovered chemokine receptor, has demonstrated its characteristics in six aspects out of the ten top hallmarks of tumors, including resisting cell death, inducing angiogenesis, sustaining proliferative signaling, activating invasion and metastasis, tumor-promoting inflammation, and cancer-related genes [14,[17][18][19][20][21][22]. Both CXCR4 and CXCR7 are receptors of chemokine CXCL12 and have been reported in multiple tumor types.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers

Qing¹,

Wen²

2016

J Integr Oncol

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Purpose: Recently, higher expression of chemokine receptors in patients with various cancer types has been observed and indicated to have prognostic significance in the clinical progression of cancers. Former research has determined that CXCR7, as a member of chemokine receptor C-X-C family, empowers greater affinity with chemokine CXCL12 than CXCR4. The present study investigated the correlation of clinical characteristics and CXCR7 expression in cancers using meta-analysis. Methods:A comprehensive search on Pubmed and Web of Science identified CXCR7-related clinical studies. Methodological quality of these studies was evaluated and all the data were extracted, calculated and analyzed. This meta-analysis was carried out with Stata 12.0. Results:Fifteen eligible studies consisting of 1780 participants were included. The results showed that CXCR7 significantly relates to tumor occurrence (pooled RR=3.12, 95% CI: 1.71-5.70, P=0.000), tumor grades (pooled RR=1.41, 95% CI: 1.14-1.75, P=0.002), tumor stages (pooled RR=1.51, 95% CI: 1.26-1.82, P=0.000) and lymph node metastasis (pooled RR=1.49, 95% CI: 1.14-1.94, P=0.000), respectively. Conclusion:Highly expressed chemokine receptor CXCR7 potentially increases tumor occurrence risk. Higher CXCR7 expression is associated with poorer prognosis, advanced stages, differentiation grades and poor lymph node metastasis in patients with various cancers. Thus, highly expressed CXCR7 could be a potential biomarker in the prognosis of cancers.

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“…There are growing evidence pointing to chemokine involvement in these organ-selective metastases [14,15], and recently, a specific role of the CXCR7/chemokine axis has been demonstrated in lung compared to liver metastases [16]. However, the differential tropism from CRC to several target sites is still not well explained, including the mechanisms that drive hepatic homing.…”

Section: Metastasismentioning

confidence: 99%

Cancer Cells with Stem Cell-Like Phenotypes and Liver Metastasis from Colon Carcinoma

Bellizzi¹,

Tommasi²

2013

J Liver

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Tumor heterogeneity contributes to the potentiality of tumors to invade and metastasize. Thus the identification of specific cells programmed to go to a specific site and establish themselves, actively proliferating and causing metastasis, could be fundamental for early diagnosis and for selective targeted therapy. Apart from gene signatures which seem to identify this tumor ability, selected cell populations with self-renewal potential have been recognized: stem cell-like cancer cells. In this paper we review recent evidence on the identification of colon cancer cells with stem cell-like properties which could have a key role in the liver metastasization. The potential clinical implication of their therapeutic eradication is also discussed. Keywords: Stem Cell-Like Cancer cells (SCLC); Colon cancer; MetastasisColorectal Cancer (CRC) is the third most common cancer in men (663,000 cases, 10.0% of the total) and the second in women (570,000 cases, 9.4% of the total) worldwide. Almost 60% of the cases occur in developed regions [1] and approximately 50% of patients develop synchronous or metachronous liver metastases within 2 years from the resection of the primary tumor [2]. Most colon cancer deaths result from the metastatic spread of tumor cells to the liver and other organs [3] and for this reason it is of great significance to identify new markers capable of discriminating earlier the potential that a primary tumor has to initiate a process of liver metastasization. The standard care in patients with operable liver-confined lesions is represented by a combination of chemotherapy and surgery [4]. However, there are still some critical issues to be solved. Firstly, surgical cures are relatively rare in this setting. Secondly, how to juxtapose chemotherapy and surgery, and the duration of chemotherapy. Finally, the possibility of pre-operative chemotherapy in the case of resectable metastases [5]. This is primarily due to the fact that current chemotherapy attacks the bulk of the cancer without affecting the chemo-resistant Stem Cell-Like Cancer cells (SCLCs). These can re-grow after treatment and, eventually, develop the changes responsible for the occurrence of drug-resistance [6][7][8] and facilitate a persistent and aggressive tumor phenotype, capable of invading other sites. In this scenario, understanding what drives metastasization to the liver and the characterization of clonal cells which selectively establish themselves in that site acquires great importance.In CRC, SCLCs are colon stem cells progenitors whose deregulated dynamics lead to the origin of a tumor [9]. At least two populations of progenitors are identified at the bottom of the normal colon Lieberkühn: true quiescent stem cells with high chemoresistance, and low proliferating potential [10]. They produce continuously the second compartment of stem cell progenitors with high mitogenic, differentiation and migratory potentials towards the top epithelium surface of the crypts. Upon migration upward through the crypt, these cells proli...

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CXCR7 receptors facilitate the progression of colon carcinoma within lung not within liver

Cited by 41 publications

References 32 publications

Knockdown of CXCR7 inhibits proliferation and invasion of osteosarcoma cells through inhibition of the PI3K/Akt and β-arrestin pathways

Knockdown of CXCR7 inhibits proliferation and invasion of osteosarcoma cells through inhibition of the PI3K/Akt and β-arrestin pathways

Meta-analysis of CXCR7 Expression Related to Clinical Prognosis in Cancers

Cancer Cells with Stem Cell-Like Phenotypes and Liver Metastasis from Colon Carcinoma

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