2019
DOI: 10.1038/s41590-019-0468-0
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Abstract: In B lymphopoiesis, activation of the pre-B cell antigen receptor (pre-BCR) is associated with both cell cycle exit and Igk recombination. Yet, how the pre-BCR mediates these functions remains unclear. Herein, we demonstrate that the pre-BCR initiated a feed-forward amplification loop mediated by the transcription factor IRF4 and the chemokine receptor CXCR4. CXCR4 ligation by CXCL12 activated the mitogen-activated protein kinase (MAPK) ERK which then directed the development of small pre-and immature B cells … Show more

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Cited by 48 publications
(57 citation statements)
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“…ATAC-Seq was performed as described 53 . Cells were washed with PBS, then lysed with ATAC lysis buffer (10 mM Tris-HCl, pH 7.4, 10 mM NaCl, 3 mM MgCl2, 0.1% IGEPAL CA-630).…”
Section: Methodsmentioning
confidence: 99%
“…ATAC-Seq was performed as described 53 . Cells were washed with PBS, then lysed with ATAC lysis buffer (10 mM Tris-HCl, pH 7.4, 10 mM NaCl, 3 mM MgCl2, 0.1% IGEPAL CA-630).…”
Section: Methodsmentioning
confidence: 99%
“…However, we would argue that such a strategy would incur unnecessary genomic risk. Furthermore, during B lymphopoiesis genomic recombination and proliferation are segregated into very different cell populations ( 47 , 48 ). As described below, this strategy is recapitulated in the GC.…”
Section: Gc Cellular Evolutionmentioning
confidence: 99%
“…Furthermore, in vitro studies suggested that CXCR4 may also act as a signaling receptor capable of influencing cell decisions. CXCR4 signaling drives HSC proliferation directly via transcriptional control of cyclin D1 and MAD1 (23), and in preB cells, CXCR4 signaling activates ERK to facilitate Igk germline transcription (35).…”
Section: Lymphoid Cells and Their Nichesmentioning
confidence: 99%