CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

Li, Xing; Bu, Wenhuan; Meng, Lin; Liu, Xinchen; Wang, Shuangshuang; Jiang, Liming; Ren, Mulan; Fan, Yu; Sun, Hongchen

doi:10.1016/j.yexcr.2019.03.013

Cited by 116 publications

(73 citation statements)

References 36 publications

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“…Moreover, TAMs, as the most cellular component in tumor stroma, were reported to induce CAF differentiation and augment tumor growth via CCL18 secretion 35 . Furthermore, CAFs were indicated to enhance TAM recruitment in tumor microenvironment by CXCL12-CXCR4 and CCL5-CCR5 axis, forming a positive feedback loop between CAFs and TAMs as well as tumor-promoting stroma 7 , 36 . Regarding the relevance of CAFs in survival, clinical retrospective researches revealed the CAF infiltration was negatively relevant to OS of ESCC and ESAD patients (ESCC: 16 vs. 51 months; ESAD: 46.80 vs. 76.45 months) 37 , 38 , which were consistent with our prediction outcome of ESCA patients based on stromal scores.…”

Section: Discussionmentioning

confidence: 99%

“…CAF-derived transform growth factor-β (TGF-β) modified the process of epithelial-mesenchymal transition (EMT) during tumor infiltration in breast cancer 6 . Similarly, CAFs were demonstrated as the major sources of chemokines, releasing CXCL12 to recruit monocytes as tumor-associated macrophages (TAMs) in tumor microenvironment 7 . In addition, CAFs promoted tumor angiogenesis in tumor stroma with vascular endothelial growth factor (VEGF) secretion to reconstruct blood vessel 8 .…”

Section: Introductionmentioning

confidence: 99%

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Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis

Zeng

Jiang

et al. 2020

Sci Rep

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The stromal microenvironment has been shown to affect the infiltration of esophageal carcinoma (ESCA), which is linked to prognosis. However, the complicated mechanism of how infiltration is influenced by the stromal microenvironment is not well-defined. In this study, a stromal activation classifier was established with ridge cox regression to calculate stroma scores for training (n = 182) and validation cohorts (n = 227) based on the stroma-related 32 hub genes identified by sequential bioinformatics algorithms. Patients with high stromal activation were associated with high T stage and poor prognosis in both esophagus adenocarcinoma and esophagus squamous cell carcinoma. Besides, comprehensive multi-omics analysis was used to outline stromal characterizations of 2 distinct stromal groups. Patients with activated tumor stoma showed high stromal cell infiltration (fibroblasts, endothelial cells, and monocyte macrophages), epithelial-mesenchymal transition, tumor angiogenesis and M2 macrophage polarization (CD163 and CD206). Tumor mutation burden of differential stromal groups was also depicted. In addition, a total of 6 stromal activation markers in ESCA were defined and involved in the function of carcinoma-associated fibroblasts that were crucial in the differentiation of distinct stromal characterizations. Based on these studies, a practical classifier for the stromal microenvironment was successfully proposed to predict the prognosis of ESCA patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis

Zeng

Jiang

et al. 2020

Sci Rep

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“…Moreover, they inhibit T-cell proliferation and IFN- γ secretion [ 75 ]. Likewise, cancer-associated fibroblasts (CAFs)-derived CXCL12 attracts monocytes with the M2 like phenotype and induces their transformation into M2 macrophages in oral squamous cell carcinoma [ 77 ]. The CXCL12/CXCR4 signaling also recruits peripheral macrophages into the brain.…”

Section: Cxcl12 Affects Both Innate and Adaptive Immunity In Cancementioning

confidence: 99%

The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis

Zielińska

Katanaev

2020

Cancers

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The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs. Moreover, the CXCL12/CXCR4 cascade affects both immune and stromal cells, creating tumor-supporting microenvironment. In this review, we examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer.

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“…Moreover, there is no doubt that cancer-associated fibroblasts (CAFs) have a critical role in maintaining the characteristics of TAMs, and the cell-cell interaction between CAFs and TAMs induces the recruitment and activation of each cell type [33,34]. CXCL12 derived from CAFs effectively attracts monocytes, and then the monocytes display the M2 macrophage phenotype, which supports tumor invasion and progression [35]. Based on this evidence, TAMs recruited by CAFs may promote GCSC properties through the upregulation of CSC marker expression.…”

Section: Gcscs and The Immune Microenvironmentmentioning

confidence: 99%

Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

Yasuda

et al. 2020

Biomedicines

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Gastric cancer (GC) is a leading cause of cancer-related death worldwide. Cancer stem cells (CSCs) are known to be involved in chemotherapy resistance and the development of metastases. Although CSCs harbor self-renewal and tumorigenic abilities, the immune microenvironment surrounding CSCs provides various factors and supports the maintenance of CSC properties. The current review summarizes the accumulating findings regarding the relationship between the immune microenvironment and gastric CSCs (GCSCs), which will support the possibility of developing novel therapeutic strategies for targeting GCSCs.

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CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC

Cited by 116 publications

References 36 publications

Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis

Stromal microenvironment promoted infiltration in esophageal adenocarcinoma and squamous cell carcinoma: a multi-cohort gene-based analysis

The Signaling Duo CXCL12 and CXCR4: Chemokine Fuel for Breast Cancer Tumorigenesis

Gastric Cancer Stem Cells: Current Insights into the Immune Microenvironment and Therapeutic Targets

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