Cutting-edge Questions About CLIPPERS (Chronic Lymphocytic Inflammation With Pontine Perivascular Enhancement Responsive to Steroids)

CLIPPERS. Three clinical cases and review

“…Íà ñåãîäíÿøíèé äåíü íå ñóùåñòâóåò ÷åòêèõ äèà-ãíîñòè÷åñêèõ êðèòåðèåâ çàáîëåâàíèÿ, ÷òî äåëàåò åãî äèàãíîçîì èñêëþ÷åíèÿ.  äèôôåðåíöèàëüíî äèàãíîñòè÷åñêèé ðÿä ñëåäóåò âêëþ÷àòü øèðîêèé ñïåêòð çàáîëåâàíèé: áîëåçíü Áåõ÷åòà, ñèíäðîì Øåãðåíà, äåìèåëèíèçèðóþùèå çàáîëåâàíèÿ ÖÍÑ, ñòâîëîâûå ýíöåôàëèòû (èíôåêöèîííûå è ïàðàíåî-ïëàñòè÷åñêèå), âàñêóëèòû ÖÍÑ (êàê ïåðâè÷íûå, òàê è âòîðè÷íûå), ëèìôîìàòîèäíûé ãðàíóëåìàòîç, ëèìôîìó ÖÍÑ, ãëèàëüíûå îïóõîëè [1,4,5,[12][13][14][15][16][17][18][19][20].…”

CLIPPERS. Three clinical cases and review

“…Íà ñåãîäíÿøíèé äåíü íå ñóùåñòâóåò ÷åòêèõ äèà-ãíîñòè÷åñêèõ êðèòåðèåâ çàáîëåâàíèÿ, ÷òî äåëàåò åãî äèàãíîçîì èñêëþ÷åíèÿ.  äèôôåðåíöèàëüíî äèàãíîñòè÷åñêèé ðÿä ñëåäóåò âêëþ÷àòü øèðîêèé ñïåêòð çàáîëåâàíèé: áîëåçíü Áåõ÷åòà, ñèíäðîì Øåãðåíà, äåìèåëèíèçèðóþùèå çàáîëåâàíèÿ ÖÍÑ, ñòâîëîâûå ýíöåôàëèòû (èíôåêöèîííûå è ïàðàíåî-ïëàñòè÷åñêèå), âàñêóëèòû ÖÍÑ (êàê ïåðâè÷íûå, òàê è âòîðè÷íûå), ëèìôîìàòîèäíûé ãðàíóëåìàòîç, ëèìôîìó ÖÍÑ, ãëèàëüíûå îïóõîëè [1,4,5,[12][13][14][15][16][17][18][19][20].…”

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS): A Rare Treatable Neuroradiological Spectrum

“…CLIPPERS is a rare chronic inflammatory neurological syndrome affecting multiple regions of the brain, including the brainstem, cerebellum, and spinal cord, that has gained recognition since its introduction in 2010 by Pittock [1]. The hallmark finding of CLIPPERS is the presence of multiple punctate, curvilinear lesions, notably showing a “peppered” appearance of the pons and other parts of the brainstem on a contrast-enhanced MRI [2], with relative sparing of the supratentorial brain. Similar punctate-type enhancement has also been described in the basal ganglia, corpus callosum, and spinal cord [3].…”

Horizontal eyeball akinesia as an initial manifestation of CLIPPERS

“…Differential diagnoses of CLIPPERS include CNS lymphoma, lymphomatoid granulomatosis, CNS infections, neurosarcoidosis, neuro-Behçet's disease, Sjögren's syndrome, MS, NMO, primary angiitis of the CNS, CNS histiocytosis, acute disseminated encephalomyelitis, Bickerstaff brainstem encephalitis, other inflammatory demyelinating CNS diseases, other autoimmune encephalitides, brainstem tumors, and paraneoplastic disorders. [1,2,10,11,7,31,39,40,41,32,42,43,6] …”

CLIPPERS. Three clinical cases and review

“…Íà ñåãîäíÿøíèé äåíü íå ñóùåñòâóåò ÷åòêèõ äèà-ãíîñòè÷åñêèõ êðèòåðèåâ çàáîëåâàíèÿ, ÷òî äåëàåò åãî äèàãíîçîì èñêëþ÷åíèÿ.  äèôôåðåíöèàëüíî äèàãíîñòè÷åñêèé ðÿä ñëåäóåò âêëþ÷àòü øèðîêèé ñïåêòð çàáîëåâàíèé: áîëåçíü Áåõ÷åòà, ñèíäðîì Øåãðåíà, äåìèåëèíèçèðóþùèå çàáîëåâàíèÿ ÖÍÑ, ñòâîëîâûå ýíöåôàëèòû (èíôåêöèîííûå è ïàðàíåî-ïëàñòè÷åñêèå), âàñêóëèòû ÖÍÑ (êàê ïåðâè÷íûå, òàê è âòîðè÷íûå), ëèìôîìàòîèäíûé ãðàíóëåìàòîç, ëèìôîìó ÖÍÑ, ãëèàëüíûå îïóõîëè [1,4,5,[12][13][14][15][16][17][18][19][20].…”

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS): A Rare Treatable Neuroradiological Spectrum

“…CLIPPERS is a rare chronic inflammatory neurological syndrome affecting multiple regions of the brain, including the brainstem, cerebellum, and spinal cord, that has gained recognition since its introduction in 2010 by Pittock [1]. The hallmark finding of CLIPPERS is the presence of multiple punctate, curvilinear lesions, notably showing a “peppered” appearance of the pons and other parts of the brainstem on a contrast-enhanced MRI [2], with relative sparing of the supratentorial brain. Similar punctate-type enhancement has also been described in the basal ganglia, corpus callosum, and spinal cord [3].…”

Horizontal eyeball akinesia as an initial manifestation of CLIPPERS

“…Differential diagnoses of CLIPPERS include CNS lymphoma, lymphomatoid granulomatosis, CNS infections, neurosarcoidosis, neuro-Behçet's disease, Sjögren's syndrome, MS, NMO, primary angiitis of the CNS, CNS histiocytosis, acute disseminated encephalomyelitis, Bickerstaff brainstem encephalitis, other inflammatory demyelinating CNS diseases, other autoimmune encephalitides, brainstem tumors, and paraneoplastic disorders. [1,2,10,11,7,31,39,40,41,32,42,43,6] …”

CLIPPERS. Three clinical cases and review

“…Íà ñåãîäíÿøíèé äåíü íå ñóùåñòâóåò ÷åòêèõ äèà-ãíîñòè÷åñêèõ êðèòåðèåâ çàáîëåâàíèÿ, ÷òî äåëàåò åãî äèàãíîçîì èñêëþ÷åíèÿ.  äèôôåðåíöèàëüíî äèàãíîñòè÷åñêèé ðÿä ñëåäóåò âêëþ÷àòü øèðîêèé ñïåêòð çàáîëåâàíèé: áîëåçíü Áåõ÷åòà, ñèíäðîì Øåãðåíà, äåìèåëèíèçèðóþùèå çàáîëåâàíèÿ ÖÍÑ, ñòâîëîâûå ýíöåôàëèòû (èíôåêöèîííûå è ïàðàíåî-ïëàñòè÷åñêèå), âàñêóëèòû ÖÍÑ (êàê ïåðâè÷íûå, òàê è âòîðè÷íûå), ëèìôîìàòîèäíûé ãðàíóëåìàòîç, ëèìôîìó ÖÍÑ, ãëèàëüíûå îïóõîëè [1,4,5,[12][13][14][15][16][17][18][19][20].…”

Chronic Lymphocytic Inflammation with Pontine Perivascular Enhancement Responsive to Steroids (CLIPPERS): A Rare Treatable Neuroradiological Spectrum

“…CLIPPERS is a rare chronic inflammatory neurological syndrome affecting multiple regions of the brain, including the brainstem, cerebellum, and spinal cord, that has gained recognition since its introduction in 2010 by Pittock [1]. The hallmark finding of CLIPPERS is the presence of multiple punctate, curvilinear lesions, notably showing a “peppered” appearance of the pons and other parts of the brainstem on a contrast-enhanced MRI [2], with relative sparing of the supratentorial brain. Similar punctate-type enhancement has also been described in the basal ganglia, corpus callosum, and spinal cord [3].…”

Horizontal eyeball akinesia as an initial manifestation of CLIPPERS

“…Differential diagnoses of CLIPPERS include CNS lymphoma, lymphomatoid granulomatosis, CNS infections, neurosarcoidosis, neuro-Behçet's disease, Sjögren's syndrome, MS, NMO, primary angiitis of the CNS, CNS histiocytosis, acute disseminated encephalomyelitis, Bickerstaff brainstem encephalitis, other inflammatory demyelinating CNS diseases, other autoimmune encephalitides, brainstem tumors, and paraneoplastic disorders. [1,2,10,11,7,31,39,40,41,32,42,43,6] …”