2003
DOI: 10.4049/jimmunol.170.4.1611
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Abstract: Perforin mediates target cell apoptosis by CTLs and NK cells. Although perforin expression correlates strongly with acute allograft rejection, perforin-deficient mice reject allografts with the same kinetics as wild-type recipients. In this study, we tested the hypothesis that while perforin is dispensable for acute rejection, it is essential for down-regulating the alloimmune response by inducing the apoptosis of host immune cells. Using a skin transplantation model, we found that perforin-deficient mice are … Show more

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Cited by 27 publications
(32 citation statements)
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“…We observed in the current study that the homeostatic proliferation of CD8 + T cells is equivalent in RAG 2/2 and perforin 2/2 RAG 2/2 mice. This is in contrast to CD8 + T cell responses to foreign histocompatibility Ags in lymphocyte-replete hosts where the absence of perforin leads to exaggerated T cell proliferation and accelerated allograft rejection (31,51). Alternatively, NK cells could regulate homeostatic T cell proliferation indirectly through interactions with dendritic cells.…”
Section: Ragmentioning
confidence: 79%
“…We observed in the current study that the homeostatic proliferation of CD8 + T cells is equivalent in RAG 2/2 and perforin 2/2 RAG 2/2 mice. This is in contrast to CD8 + T cell responses to foreign histocompatibility Ags in lymphocyte-replete hosts where the absence of perforin leads to exaggerated T cell proliferation and accelerated allograft rejection (31,51). Alternatively, NK cells could regulate homeostatic T cell proliferation indirectly through interactions with dendritic cells.…”
Section: Ragmentioning
confidence: 79%
“…CTL Assays. Tc1 and Tc2 effector cell cytolytic activity was determined in a standard 51 Cr release assay (40). Adoptive Immunotherapy Model.…”
Section: Methodsmentioning
confidence: 99%
“…Although gene expression for the cytolytic mediators perforin and granzymes clearly correlates with graft rejection, [51][52][53] perforin is also necessary for tolerance induction. 32,54 The exact role for perforin in tolerance is not yet clear, but cytolytic molecules such as perforin 55 and granzymes 56 have been implicated in the function of Treg. Although cytotoxic activity by Treg has been clearly demonstrated, our own results suggest that this is not required for long-term allograft survival.…”
Section: What Is the Relationship Between Nk Cell And Regulatory T Cementioning
confidence: 99%