Cutting Edge in Thyroid Surgery: Autofluorescence of Parathyroid Glands

Falcó, Jorge; Dip, Fernando; Quadri, Pablo; Fuente, Martin De La; Rosenthal, Raúl J.

doi:10.1016/j.jamcollsurg.2016.04.049

Cited by 110 publications

(74 citation statements)

References 31 publications

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“…Moreover, this intraoperative imaging technique results in false positives, where brown fat, colloidal nodules, or metastatic lymph nodes may exhibit an autofluorescence that overlaps that of the parathyroid tissue [20,21].…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands

Demarchi

Karenovicŝ

Bédat

et al. 2020

JCM

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Fluorescence imaging is a well-known method for both the in vivo and in vitro identification of specific cells or tissues. This imaging tool is gaining importance in the intraoperative detection and preservation of parathyroid glands during endocrine surgery owing to the intrinsic properties of parathyroid tissue. The aim of this paper is to provide an overview of the basics of the technology, its history, and the recent surgical intraoperative applications of near-infrared imaging methods. Moreover, a literature review of the utilization of fluorescence devices in thyroid surgery suggests that the use of near-infrared imaging seems to be beneficial in reducing postoperative hypoparathyroidism, which is one of the most frequent complications of thyroid surgery.

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Section: Discussionmentioning

confidence: 99%

Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands

Demarchi

Karenovicŝ

Bédat

et al. 2020

JCM

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“…However, near-infrared spectroscopy provides only the point measurements and requires contact with tissues, hence its value in localization of PGs is lower compared to near-infrared autofluorescence imaging. Falco et al presented NIR imaging using a commercial device, the Fluobeam 800 laser (Fluoptics, Grenoble France) [56]. Other research groups used different either commercial or home-made devices [57,59,77].…”

Section: Near-infrared Autofluorescencementioning

confidence: 99%

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

et al. 2020

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Accurate pre-operative determination of parathyroid glands localization is critical in the selection of minimally invasive parathyroidectomy as a surgical treatment approach in patients with primary hyperparathyroidism (PHPT). Its importance cannot be overemphasized as it helps to minimize the harmful side effects associated with damage to the parathyroid glands such as in hypocalcemia, severe hemorrhage or recurrent laryngeal nerve dysfunction. Preoperative and intraoperative methods decrease the incidence of mistakenly injuring the parathyroid glands and allow for the timely diagnosis of various abnormalities, including parathyroid adenomas. This article reviews 139 studies conducted between 1970 and 2020 (49 years). Studies that were reviewed focused on several techniques including application of carbon nanoparticles, carbon nanoparticles with technetium sestamibi (99m Tc-MIBI), Raman spectroscopy, near-infrared autofluorescence, dynamic optical contrast imaging, laser speckle contrast imaging, shear wave elastography, and indocyanine green to test their potential in providing proper parathyroid glands’ localization. Apart from reviewing the aforementioned techniques, this study focused on the applications that helped in the detection of parathyroid adenomas. Results suggest that applying all the reviewed techniques significantly improves the possibility of providing proper localization of parathyroid glands, and the application of indocyanine green has proven to be the ‘ideal’ approach for the diagnosis of parathyroid adenomas.

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“…In 2016, an Argentinian group also studied the autofluorescent properties of the parathyroid gland using the commercially available Fluobeam 800 ® device (Fluoptics, Grenoble, France). This study of 28 patients was in line with the previous studies in confirming the autofluorescent properties of the parathyroid glands.…”

Section: Introductionmentioning

confidence: 99%

The use of near‐infrared fluorescence imaging in endocrine surgical procedures

Kahramangil

Berber

2017

Journal of Surgical Oncology

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Near-infrared fluorescence imaging in endocrine surgery is a new, yet highly investigated area. It involves indocyanine green use as well as parathyroid autofluorescence. Several groups have described their technique and reported on the observed utility. However, there is no consensus on technical details. Furthermore, the correlation between intraoperative findings and postoperative outcomes is unclear. With this study, we aim to review the current literature on fluorescence imaging and share our insights on technical details.

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Cutting Edge in Thyroid Surgery: Autofluorescence of Parathyroid Glands

Cited by 110 publications

References 31 publications

Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands

Intraoperative Autofluorescence and Indocyanine Green Angiography for the Detection and Preservation of Parathyroid Glands

Preoperative and Intraoperative Methods of Parathyroid Gland Localization and the Diagnosis of Parathyroid Adenomas

The use of near‐infrared fluorescence imaging in endocrine surgical procedures

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