Rocky L. Baker, Thomas Delong, Gene Barbour, Brenda Bradley, Maki Nakayama, Kathryn Haskins
We previously reported a peptide KS20 from islet amyloid polypeptide (IAPP) to be the target antigen for a highly diabetogenic CD4 T cell clone BDC-5.2.9. In order to track IAPP-reactive T cells in NOD mice and determine how they contribute to the pathogenesis of type 1 diabetes (T1D), we designed a new I-Ag7 tetramer with high affinity for BDC-5.2.9 that contains the peptide KS20. We found that significant numbers of KS20 tetramer-positive CD4 T cells can be detected in the pancreas of pre-diabetic and diabe…
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